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Volumn 139, Issue 2, 2014, Pages 432-451

Regulation of copper transport crossing brain barrier systems by CU-ATPases: Effect of manganese exposure

Author keywords

Blood csf barrier; Bloodbrain barrier; Copper; Copper transport; Cu ATPases; Manganese

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (COPPER); COPPER 64; MANGANESE; MENKES PROTEIN; MESSENGER RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WILSON DISEASE PROTEIN; ATP7A PROTEIN, RAT; ATP7B PROTEIN, RAT; CATION TRANSPORT PROTEIN; CHLORIDE; COPPER; CUPRIC CHLORIDE; MANGANESE CHLORIDE; MANGANESE DERIVATIVE;

EID: 84899921362     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu048     Document Type: Article
Times cited : (45)

References (69)
  • 1
    • 0038249175 scopus 로고    scopus 로고
    • DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells
    • Arredondo, M., Munoz, P., Mura, C. V., and Nunez, M. T. (2003). DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells. Am. J. Physiol. Cell Physiol. 284, C1525-C1530.
    • (2003) Am. J. Ph ysiol. Cell Physiol , vol.284
    • Arredondo, M.1    Munoz, P.2    Mura, C.V.3    Nunez, M.T.4
  • 2
    • 0028366603 scopus 로고
    • Manganese (Mn) transport across the rat blood-brain barrier: Saturable and transferrin-dependent transport mechanisms
    • Aschner, M., and Gannon, M. (1994). Manganese (Mn) transport across the rat blood-brain barrier: Saturable and transferrin-dependent transport mechanisms. Brain Res. Bull. 33, 345-349.
    • (1994) Brain Res.Bull , vol.33 , pp. 345-349
    • Aschner, M.1    Gannon, M.2
  • 3
    • 0016906735 scopus 로고
    • Role of manganese in dystonia
    • Barbeau, A., Inoúe, N., and Cloutier, T. (1976). Role of manganese in dystonia. Adv. Neurol. 14, 339-352.
    • (1976) Adv. Neurol , vol.14 , pp. 339-352
    • Barbeau, A.1    Inoúe, N.2    Cloutier, T.3
  • 5
    • 84862218417 scopus 로고    scopus 로고
    • In vivo techniques used in blood-CSF barrier research: Measurement of CSF formation
    • (W. Zheng and A. Chodvn1bski Eds)CRC Press, New York.In
    • Chodobski, A., and Segal, M. B. (2005). In vivo techniques used in blood-CSF barrier research: Measurement of CSF formation. In: The Blood-Cerebrospinal Fluid Barrier (W. Zheng and A. Chodobski, Eds.), pp. 595-605. CRC Press, New York.
    • (2005) The B lood-Cerebrospinal Fluid Barrier , pp. 595-605
    • Chodobski, A.1    Segal, M.B.2
  • 6
    • 57649158930 scopus 로고    scopus 로고
    • Copper transport to the brain by the bloodbrain barrier and blood-CSF barrier
    • Choi, B. S., and Zheng, W. (2009). Copper transport to the brain by the bloodbrain barrier and blood-CSF barrier. Brain Res. 1248, 14-21.
    • (2009) Brain Res , vol.1248 , pp. 14-21
    • Choi, B.S.1    Zheng, W.2
  • 7
    • 27644457417 scopus 로고    scopus 로고
    • The choroid plexus removes beta-amyloid from the cerebrospinal fluid
    • Crossgrove, J. S., Li, G. J., and Zheng, W. (2005). The choroid plexus removes beta-amyloid from the cerebrospinal fluid. Exp. Biol. Med. 230, 771-776.
    • (2005) Exp. Biol. Med , vol.230 , pp. 771-776
    • Crossgrove, J.S.1    Li, G.J.2    Zheng, W.3
  • 8
    • 12344250905 scopus 로고    scopus 로고
    • Manganese toxicity upon overexposure
    • Crossgrove, J. S., and Zheng, W. (2004). Manganese toxicity upon overexposure. NMR Biomed. 17, 544-553.
    • (2004) NMR Biomed , vol.17 , pp. 544-553
    • Crossgrove, J.S.1    Zheng, W.2
  • 9
    • 1042301280 scopus 로고    scopus 로고
    • Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain
    • Deane, R., Zheng, W., and Zlokovic, B. V. (2004). Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J. Neurochem. 88, 813-820.
    • (2004) J. Neurochem , vol.88 , pp. 813-820
    • Deane, R.1    Zheng, W.2    Zlokovic, B.V.3
  • 10
    • 78349272389 scopus 로고    scopus 로고
    • Somatic mosaicism inMenkes disease suggests choroid plexus-mediated copper transport to the developing brain
    • Donsante, A., Johnson, P., Jansen, L. A., and Kaler, S. G. (2010). Somatic mosaicism inMenkes disease suggests choroid plexus-mediated copper transport to the developing brain. Am. J. Med. Genet. A 152A, 2529-2534.
    • (2010) Am. J. Med . Genet. A , vol.152 A , pp. 2529-2534
    • Donsante, A.1    Johnson, P.2    Jansen, L.A.3    Kaler, S.G.4
  • 11
    • 82955232408 scopus 로고    scopus 로고
    • ATP7A gene addition to the choroid plexus results in long-term rescue of the lethal copper transport defect in a Menkes disease mouse model
    • Donsante, A., Yi, L., Zerfas, P. M., Brinster, L. R., Sullivan, P., Goldstein, D. S., Prohaska, J., Centeno, J. A., Rushing, E., and Kaler, S. G. (2011). ATP7A gene addition to the choroid plexus results in long-term rescue of the lethal copper transport defect in a Menkes disease mouse model. Mol. Ther. 19, 2114-2123.
    • (2011) Mol. Ther , vol.19 , pp. 2114-2123
    • Donsante, A.1    Yi, L.2    Zerfas, P.M.3    Brinster, L.R.4    Sullivan, P.5    Goldstein, D.S.6    Prohaska, J.7    Centeno, J.A.8    Rushing, E.9    Kaler, S.G.10
  • 12
    • 79955846348 scopus 로고    scopus 로고
    • In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese
    • Dydak, U., Jiang, Y. M., Long, L. L., Zhu, H., Chen, J., Li, W. M., Edden, R. A. E., Hu, S. G., Fu, X., Long, Z. Y., et al. (2011). In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese. Environ. Health Perspect. 119, 219-224.
    • (2011) Environ. Health Perspect , vol.119 , pp. 219-224
    • Dydak, U.1    Jiang, Y.M.2    Long, L.L.3    Zhu, H.4    Chen, J.5    Li, W.M.6    Edden, R.A.E.7    Hu, S.G.8    Fu, X.9    Long, Z.Y.10
  • 13
    • 0036778081 scopus 로고    scopus 로고
    • Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes
    • Erikson, K. M., and Aschner, M. (2002). Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes. Neurotoxicology 23, 595-602.
    • (2002) Neurotoxicology , vol.23 , pp. 595-602
    • Erikson, K.M.1    Aschner, M.2
  • 14
    • 33745726690 scopus 로고    scopus 로고
    • Copper homeostasis and neurodegenerative disorders (Alzheimeŕs, Prion, and Parkinson's diseases and amyotrophic lateral sclerosis)
    • Gaggelli, E., Kozlowski, H., Valensin, D., and Valensin, G. (2006). Copper homeostasis and neurodegenerative disorders (Alzheimeŕs, Prion, and Parkinson's diseases and amyotrophic lateral sclerosis). Chem. Rev. 106, 1995-2044.
    • (2006) Chem. Rev , vol.106 , pp. 1995-2044
    • Gaggelli, E.1    Kozlowski, H.2    Valensin, D.3    Valensin, G.4
  • 16
    • 35649024149 scopus 로고    scopus 로고
    • Manganese inhibits NMDA receptor channel function: Implications to psychiatric and cognitive effects
    • Guilarte, T. R., and Chen, M. K. (2007). Manganese inhibits NMDA receptor channel function: Implications to psychiatric and cognitive effects. Neurotoxicology 28, 1147-1152.
    • (2007) Neurotoxicology , vol.28 , pp. 1147-1152
    • Guilarte, T.R.1    Chen, M.2
  • 17
    • 33751423865 scopus 로고    scopus 로고
    • Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study
    • Guilarte, T.R., McGlothan, J.L., Degaonkar, M., Chen, M.K., Barker, P.B., Syversen, T., and Schneider, J.S. (2006) Evidence for cortical dysfunction and widespread manganese accumulation in the nonhuman primate brain following chronic manganese exposure: a 1H-MRS and MRI study.. Toxicol Sci, 94, 351-358.
    • (2006) Toxicol Sci , vol.94 , pp. 351-358
    • Guilarte, T.R.1    McGlothan, J.L.2    Degaonkar, M.3    Chen, M.K.4    Barker, P.B.5    Syversen, T.6    Schneider, J.S.7
  • 20
    • 0029930329 scopus 로고    scopus 로고
    • Localization ofMenkes gene expression in the mouse brain: Its associateion with neurological manifestation in Menkes model mice
    • Iwase, T., Nishimura, M., Sugimura, H., Igarashi, H., Ozawa, F., Shinmura, K., Suzuki,M., Tanaka,M., andKino, I. (1996). Localization ofMenkes gene expression in the mouse brain: Its associateion with neurological manifestation in Menkes model mice. Acta Neuropathol. 91, 482-488.
    • (1996) Acta Neuropathol , vol.91 , pp. 482-488
    • Iwase, T.1    Nishimura, M.2    Sugimura, H.3    Igarashi, H.4    Ozawa, F.5    Shinmura, K.6    Suzuki, M.7    Tanaka, M.8    Kino, I.9
  • 21
    • 33745186471 scopus 로고    scopus 로고
    • Effective treatment ofmanganeseinduced occupational parkinsonism with p-aminosalicylic acid: A case of 17-year follow-up study
    • Jiang, Y. M., Mo, X. A., Du, F. Q., Fu, X., Zhu, X. Y., Gao, H. Y., Xie, J. L., Liao, F. L., Pira, E., and Zheng, W. (2006). Effective treatment ofmanganeseinduced occupational parkinsonism with p-aminosalicylic acid: A case of 17-year follow-up study. J. Occup. Environ. Med. 48, 644-649.
    • (2006) J. Occup. Environ.Med , vol.48 , pp. 644-649
    • Jiang, Y.M.1    Mo, X.A.2    Du, F.Q.3    Fu, X.4    Zhu, X.Y.5    Gao, H.Y.6    Xie, J.L.7    Liao, F.L.8    Pira, E.9    Zheng, W.10
  • 22
    • 33846624631 scopus 로고    scopus 로고
    • Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: Search for biomarkers of manganese exposure
    • Jiang, Y. M., Zheng, W., Long, L. L., Zhao, W. J., Li, X. R.,Mo, X. A., Lu, J. P., Fu, X., Li,W.M., Liu, S. F., et al. (2007). Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: Search for biomarkers of manganese exposure. Neurotoxicology 28, 126-135.
    • (2007) Neurotoxicology , vol.28 , pp. 126-135
    • Jiang, Y.M.1    Zheng, W.2    Long, L.L.3    Zhao, W.J.4    Li, X.R.5    Mo, X.A.6    Lu, J.P.7    Fu, X.8    Li, W.M.9    Liu, S.F.10
  • 23
    • 78651355486 scopus 로고    scopus 로고
    • ATP7A-related copper transport diseases-Emerging concepts and future trends
    • Kaler, S. G. (2011). ATP7A-related copper transport diseases-Emerging concepts and future trends. Nat. Rev. Neurol. 7, 15-29.
    • (2011) Nat. Rev. Neurol , vol.7 , pp. 15-29
    • Kaler, S.G.1
  • 24
    • 4544377971 scopus 로고    scopus 로고
    • Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis
    • Kiaei, M., Bush, A. I., Morrison, B. M., Morrison, J. H., Cherny, R. A., and Volitakis, I. (2004). Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis. J. Neurosci. 24, 7945-7950.
    • (2004) J. Neurosci , vol.24 , pp. 7945-7950
    • Kiaei, M.1    Bush, A.I.2    Morrison, B.M.3    Morrison, J.H.4    Cherny, R.A.5    Volitakis, I.6
  • 25
    • 0030751819 scopus 로고    scopus 로고
    • Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transporters
    • Kuo, Y. M., Gitschier, J., and Packman, S. (1997). Developmental expression of the mouse mottled and toxic milk genes suggests distinct functions for the Menkes and Wilson disease copper transporters. Hum. Mol. Genet. 6, 1043-1049.
    • (1997) Hum. Mol. Genet , vol.6 , pp. 1043-1049
    • Kuo, Y.M.1    Gitschier, J.2    Packman, S.3
  • 26
    • 3242701547 scopus 로고    scopus 로고
    • Biology, structure and mechanism of P-type ATPases
    • Kühlbrandt, W. (2004). Biology, structure and mechanism of P-type ATPases. Nat. Rev. Mol. Cell Biol. 5, 282-295.
    • (2004) Nat. Rev. Mol. Cell Biol , vol.5 , pp. 282-295
    • Kühlbrandt, W.1
  • 27
    • 0032867286 scopus 로고    scopus 로고
    • Transendothelial permeability changes induced by free radicals in an in vitro model of the blood-brain barrier
    • Lagrange, P., Romero, I. A., Minn, A., and Revest, P. A. (1999). Transendothelial permeability changes induced by free radicals in an in vitro model of the blood-brain barrier. Free Radic. Biol. Med. 27, 667-672.
    • (1999) Free Radic. Biol. Med , vol.27 , pp. 667-672
    • Lagrange, P.1    Romero, I.A.2    Minn, A.3    Revest, P.A.4
  • 29
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) method
    • Livak, K. J., and Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) method. Methods 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 30
    • 18944369545 scopus 로고    scopus 로고
    • Alteration at translational but not transcriptional level of transferring receptor expression following manganese exposure at the blood-CSF barrier in vitro
    • Li, G. J., Zhao, Q., and Zheng, W. (2005). Alteration at translational but not transcriptional level of transferring receptor expression following manganese exposure at the blood-CSF barrier in vitro. Toxicol. Appl. Pharmacol. 205, 188-200.
    • (2005) Toxicol. Appl. Pharmacol , vol.205 , pp. 188-200
    • Li, G.J.1    Zhao, Q.2    Zheng, W.3
  • 31
    • 84855719617 scopus 로고    scopus 로고
    • The iron transporter ferroportin can also function as a manganese exporter
    • Madejczyk, M. S., and Ballatori, N. (2012). The iron transporter ferroportin can also function as a manganese exporter. Biochim. Biophys. Acta 1818, 651-657.
    • (2012) Biochim. Biophys. Acta , vol.1818 , pp. 651-657
    • Madejczyk, M.S.1    Ballatori, N.2
  • 32
    • 0036158844 scopus 로고    scopus 로고
    • Early cell transplantation in LEC rats modelingWilson's disease eliminates hepatic copper with reversal of liver disease
    • Malhi, H., Irani, A.N., Volenberg, I., Schilsky, M.L., and Gupta, S. (2002) Early cell transplantation in LEC rats modelingWilson's disease eliminates hepatic copper with reversal of liver disease.. Gastroenterology, 122, 438-447.
    • (2002) Gastroenterology , vol.122 , pp. 438-447
    • Malhi, H.1    Irani, A.N.2    Volenberg, I.3    Schilsky, M.L.4    Gupta, S.5
  • 34
    • 80855143780 scopus 로고    scopus 로고
    • Regulation of brain copper homeostasis by the brain barrier systems: Effects of Fe-overload and Fe-deficiency
    • Monnot, A. D., Behl, M., Ho, S., and Zheng, W. (2011). Regulation of brain copper homeostasis by the brain barrier systems: Effects of Fe-overload and Fe-deficiency. Toxicol. Appl. Pharmacol. 256, 249-257.
    • (2011) Toxicol. Appl. Pharmacol , vol.256 , pp. 249-257
    • Monnot, A.D.1    Behl, M.2    Ho, S.3    Zheng, W.4
  • 35
    • 84870566287 scopus 로고    scopus 로고
    • Culture of choroid plexus epithelial cells and in vitro model of blood-CSF barrier
    • 2nd ed (S. R. Randell and M. L. Fulcher Eds.)Springer Science+Business Media, LLC.
    • Monnot, A. D., and Zheng, W. (2012). Culture of choroid plexus epithelial cells and in vitro model of blood-CSF barrier. In Epithelial Cell Culture Protocols, Methods in Molecular Biology, 2nd ed. (S. R. Randell and M. L. Fulcher Eds.), Vol. 945, pp. 13-29. Springer Science+Business Media, LLC.
    • (2012) In Epitheli al Cell Culture Protcols Methods in Molecular Biology , vol.945 , pp. 13-29
    • Monnot, A.D.1    Zheng, W.2
  • 36
    • 84858785922 scopus 로고    scopus 로고
    • Mechanism of copper transport at the blood-cerebrospinal fluid barrier: Influence of iron deficiency in an in vitro model
    • Monnot, A. D., Zheng, G., and Zheng, W. (2012). Mechanism of copper transport at the blood-cerebrospinal fluid barrier: Influence of iron deficiency in an in vitro model. Exp. Biol. Med. (Maywood) 237, 327-333.
    • (2012) Exp. Biol. Med.(Maywood) , vol.237 , pp. 327-333
    • Monnot, A.D.1    Zheng, G.2    Zheng, W.3
  • 37
    • 34147106917 scopus 로고    scopus 로고
    • Dynamics of endogenous ATP7A (Menkes protein) in intestinal epithelial cells: copper-dependent redistribution between two intracellular sites
    • Nyasae, L., Bustors, R., Braiterman, L., Eipper, B., and Hubbard, A. (2007) Dynamics of endogenous ATP7A (Menkes protein) in intestinal epithelial cells: copper-dependent redistribution between two intracellular sites.. Am J Physiol Gastrointest Liver Physiol, 292, G1181-G1194.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Nyasae, L.1    Bustors, R.2    Braiterman, L.3    Eipper, B.4    Hubbard, A.5
  • 39
    • 0029909937 scopus 로고    scopus 로고
    • Ligand-regulated transport of the Menkes copper Ptype ATPase efflux pump from the Golgi apparatus to the plasma membrane: A novel mechanism of regulated trafficking
    • Petris, M. J., Mercer, J. F. B., Culvenor, J. G., Lockhart, P., Gleeson, P. A., and Camakaris, J. (1996). Ligand-regulated transport of the Menkes copper Ptype ATPase efflux pump from the Golgi apparatus to the plasma membrane: A novel mechanism of regulated trafficking. EMBO J. 15, 6084-6095.
    • (1996) Embo J , vol.15 , pp. 6084-6095
    • Petris, M.J.1    Mercer, J.F.B.2    Culvenor, J.G.3    Lockhart, P.4    Gleeson, P.A.5    Camakaris, J.6
  • 40
    • 0029024640 scopus 로고
    • Permeability of the developing blood-brain barrier to 14C-mannitol using the rat in situ brain perfusion technique
    • Preston, J. E., al-Sarraf, H., and Segal, M. B. (1995). Permeability of the developing blood-brain barrier to 14C-mannitol using the rat in situ brain perfusion technique. Brain Res. Dev. Brain Res. 87, 69-76.
    • (1995) Brain Res. Dev. Brain Res. , vol.87 , pp. 69-76
    • Preston, J.E.1    Al-Sarraf, H.2    Segal, M.B.3
  • 41
    • 0031829282 scopus 로고    scopus 로고
    • Copper efflux from murine microvascular cells requires expression of Menke's disease Cu-ATPase
    • Qian, Y., Tiffany-Castiglioni, E., Welsh, J., and Harris, E. D. (1998). Copper efflux from murine microvascular cells requires expression of Menke's disease Cu-ATPase. J. Nutr. 128, 1276-1282.
    • (1998) J. Nutr , vol.128 , pp. 1276-1282
    • Qian, Y.1    Tiffany-Castiglioni, E.2    Welsh, J.3    Harris, E.D.4
  • 43
    • 19444374381 scopus 로고    scopus 로고
    • Manganese oxidation state mediates toxicity in PC 12 cells
    • Reaney, S. H., and Smith, D. R. (2005). Manganese oxidation state mediates toxicity in PC 12 cells. Toxicol. Appl. Pharmacol. 205, 271-281.
    • (2005) Toxicol. Appl. Pharmacol , vol.205 , pp. 271-281
    • Reaney, S.H.1    Smith, D.R.2
  • 44
    • 0344980089 scopus 로고    scopus 로고
    • Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line GPNT
    • Régina, A., Romero, I., Greenwood, J., Adamson, P., Bourre, J., Couraud, P., and Roux, F. (1999). Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line GPNT. J. Neurochem. 73, 1954-1963.
    • (1999) J. Neurochem , vol.73 , pp. 1954-1963
    • Régina, A.1    Romero, I.2    Greenwood, J.3    Adamson, P.4    Bourre, J.5    Couraud, P.6    Roux, F.7
  • 45
    • 25144516489 scopus 로고    scopus 로고
    • Establishment of an in vitro brain barrier epithelial transport system for pharmacological and toxicological study
    • Shi, L. Z., and Zheng, W. (2005). Establishment of an in vitro brain barrier epithelial transport system for pharmacological and toxicological study. Brain Res. 1057, 37-48.
    • (2005) Brain Res , vol.1057 , pp. 37-48
    • Shi, L.Z.1    Zheng, W.2
  • 46
    • 0141702360 scopus 로고    scopus 로고
    • Trace amounts of copper in water induce b-amyloid plagues and learning deficits in a rabbitmodel of Alzheimeŕs disease
    • Sparks, L. S., and Schreurs, B. G. (2003). Trace amounts of copper in water induce b-amyloid plagues and learning deficits in a rabbitmodel of Alzheimeŕs disease. Proc. Natl. Acad. Sci. U.S.A. 100, 11065-11069.
    • (2003) Proc. Natl. Acad. Sci. U.S.A , vol.100 , pp. 11065-11069
    • Sparks, L.S.1    Schreurs, B.G.2
  • 48
    • 0035872487 scopus 로고    scopus 로고
    • Copper in disorders with neurological symptoms: Alzheimer's, Menkes, and Wilson diseases
    • Strausak, D., Mercer, J. F., Dieter, H. H., Stremmel, W., and Multhaup, G. (2001). Copper in disorders with neurological symptoms: Alzheimer's, Menkes, and Wilson diseases. Brain Res. Bull. 55, 175-185.
    • (2001) Brain Res. Bull , vol.55 , pp. 175-185
    • Strausak, D.1    Mercer, J.F.2    Dieter, H.H.3    Stremmel, W.4    Multhaup, G.5
  • 51
    • 0024399985 scopus 로고
    • Retention and distribution of manganese in the mouse brain following acute exposure on postnatal day 0, 7, 14 or 42: An autoradiographic and gamma counting study
    • Valois, A. A., and Webster, W. S. (1989). Retention and distribution of manganese in the mouse brain following acute exposure on postnatal day 0, 7, 14 or 42: An autoradiographic and gamma counting study. Toxicology 57, 315-328.
    • (1989) Toxicology , vol.57 , pp. 315-328
    • Valois, A.A.1    Webster, W.S.2
  • 52
    • 0025810745 scopus 로고
    • Dopamine metabolism alterations in a manganese-treated pheochromocytoma cell line (PC12)
    • Vescovi, A., Facheris, L., Zaffaroni, A., Malanca, G., and Parati, E. A. (1991). Dopamine metabolism alterations in a manganese-treated pheochromocytoma cell line (PC12). Toxicology 67, 129-142.
    • (1991) Toxicology , vol.67 , pp. 129-142
    • Vescovi, A.1    Facheris, L.2    Zaffaroni, A.3    Malanca, G.4    Parati, E.A.5
  • 53
    • 37049030609 scopus 로고    scopus 로고
    • Alteration of saliva and serumconcentrations of manganese, copper, zinc, cadmium and lead among career welders
    • Wang, D. X., Du, X. Q., and Zheng, W. (2008a). Alteration of saliva and serumconcentrations of manganese, copper, zinc, cadmium and lead among career welders. Toxicol. Lett. 176, 40-47.
    • (2008) Toxicol. Lett , vol.176 , pp. 40-47
    • Wang, D.X.1    Du, X.Q.2    Zheng, W.3
  • 54
    • 33745907562 scopus 로고    scopus 로고
    • Upregulation of DMT1 expression in choroidal epithelial of the blood-CSF barrier following manganese exposure in vitro
    • Wang, X. Q., Li, G. J., and Zheng, W. (2006). Upregulation of DMT1 expression in choroidal epithelial of the blood-CSF barrier following manganese exposure in vitro. Brain Res. 1097, 1-10.
    • (2006) Brain Res , vol.1097 , pp. 1-10
    • Wang, X.Q.1    Li, G.J.2    Zheng, W.3
  • 55
    • 58749083614 scopus 로고    scopus 로고
    • Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier: Effect of manganese exposure
    • Wang, X. Q., Li, G. J., and Zheng, W. (2008b). Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier: Effect of manganese exposure. Exp. Biol. Med. 233, 1561-1571.
    • (2008) Exp. Biol. Med , vol.233 , pp. 1561-1571
    • Wang, X.Q.1    Li, G.J.2    Zheng, W.3
  • 56
    • 0036628677 scopus 로고    scopus 로고
    • Effects of manganese (Mn) on the developing rat brain:Oxidativestress related endpoints
    • Weber, S., Dorman, D. C., Lash, L. H., Erikson, K., Vrana, K. E., and Aschner, M. (2002). Effects of manganese (Mn) on the developing rat brain:Oxidativestress related endpoints. Neurotoxicology 23, 169-175.
    • (2002) Neurotoxicology , vol.23 , pp. 169-175
    • Weber, S.1    Dorman, D.C.2    Lash, L.H.3    Erikson, K.4    Vrana, K.E.5    Aschner, M.6
  • 57
    • 0041736008 scopus 로고    scopus 로고
    • Developmental aspects of blood-brain barrier (BBB) and rat brain endothelial (RBE4) cells as in vitro model for studies on chlorpyrifostransport
    • Yang, J., and Aschner, M. (2003).Developmental aspects of blood-brain barrier (BBB) and rat brain endothelial (RBE4) cells as in vitro model for studies on chlorpyrifostransport. Neurotoxicology 24, 741-745.
    • (2003) Neurotoxicology , vol.24 , pp. 741-745
    • Yang, J.1    Aschner, M.2
  • 58
    • 75949088067 scopus 로고    scopus 로고
    • Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation
    • Yin, Z., Jiang, H., Lee, E. Y., Ni,M., Erikson, K. M.,Milatovic, D., Bowman,A.B., and Aschner, M. (2010). Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation. J. Neurochem. 112, 1190-1198.
    • (2010) J. Neurochem , vol.112 , pp. 1190-1198
    • Yin, Z.1    Jiang, H.2    Lee, E.Y.3    Ni, M.4    Erikson, K.M.5    Milatovic, D.6    Bowman, A.B.7    Aschner, M.8
  • 59
    • 0035151658 scopus 로고    scopus 로고
    • Toxicology of choroid plexus: Special reference to metalinduced neurotoxicities
    • Zheng, W. (2001a). Toxicology of choroid plexus: Special reference to metalinduced neurotoxicities. Microsc. Res. Tech. 52, 89-103.
    • (2001) Microsc. Res. Tech , vol.52 , pp. 89-103
    • Zheng, W.1
  • 60
    • 0035659525 scopus 로고    scopus 로고
    • Neurotoxicology of the brain barrier system: New implications
    • Zheng, W. (2001b). Neurotoxicology of the brain barrier system: New implications. J. Toxicol. -Clin. Toxicol. 39, 711-719.
    • (2001) J. Toxicol.-Clin. Toxicol , vol.39 , pp. 711-719
    • Zheng, W.1
  • 61
    • 84859988715 scopus 로고    scopus 로고
    • Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: Implication in manganese-induced neurotoxicity
    • Zheng, G., Chen, J., and Zheng, W. (2012). Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: Implication in manganese-induced neurotoxicity. Toxicol. Appl. Pharmacol. 260, 285-293.
    • (2012) Toxicol. Appl. Pharmacol , vol.260 , pp. 285-293
    • Zheng, G.1    Chen, J.2    Zheng, W.3
  • 62
    • 61949131895 scopus 로고    scopus 로고
    • Chelation therapy of manganese intoxication by paraaminosalicylic acid (PAS) in Sprague-Dawley rats
    • Zheng, W., Jiang, Y. M., Zhang, Y. S., Jiang, W., Wang, X. Q., and Cowan, D. M. (2009). Chelation therapy of manganese intoxication by paraaminosalicylic acid (PAS) in Sprague-Dawley rats. Neurotoxicology 30, 240-248.
    • (2009) Neurotoxicology , vol.30 , pp. 240-248
    • Zheng, W.1    Jiang, Y.M.2    Zhang, Y.S.3    Jiang, W.4    Wang, X.Q.5    Cowan, D.M.6
  • 63
    • 0034111179 scopus 로고    scopus 로고
    • Comparative toxicokinetics of manganese chloride and methylcyclopentadienyl manganese tricarbonyl (MMT) in Sprague-Dawley rats
    • Zheng, W., Kim, H., and Zhao, Q. (2000). Comparative toxicokinetics of manganese chloride and methylcyclopentadienyl manganese tricarbonyl (MMT) in Sprague-Dawley rats. Toxicol. Sci. 54, 295-301.
    • (2000) Toxicol. Sci , vol.54 , pp. 295-301
    • Zheng, W.1    Kim, H.2    Zhao, Q.3
  • 64
    • 84856489978 scopus 로고    scopus 로고
    • Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases
    • Zheng, W., and Monnot, A. D. (2012). Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases. Pharmacol. Ther. 133, 177-188.
    • (2012) Pharmacol. Ther , vol.133 , pp. 177-188
    • Zheng, W.1    Monnot, A.D.2
  • 65
    • 0032551697 scopus 로고    scopus 로고
    • Manganese inhibits mitochondrial aconitase: A mechanism of manganese neurotoxicity
    • Zheng, W., Ren, S., and Graziano, J. H. (1998). Manganese inhibits mitochondrial aconitase: A mechanism of manganese neurotoxicity. Brain Res. 799, 334-342.
    • (1998) Brain Res , vol.799 , pp. 334-342
    • Zheng, W.1    Ren, S.2    Graziano, J.H.3
  • 66
    • 84899984562 scopus 로고    scopus 로고
    • In situ techniques used in the blood-CSF barrier research
    • In: W. Zheng and A. Chodobski Eds)CRC Press, New York
    • Zheng, W., and Segal, M. B. (2005). In situ techniques used in the blood-CSF barrier research. In: The Blood-Cerebrospinal Barrier (W. Zheng and A. Chodobski, Eds.), pp. 541-551. CRC Press, New York.
    • (2005) The Blood-Cerebrospinal Barrier , pp. 541-551
    • Zheng, W.1    Segal, M.B.2
  • 67
    • 0037184711 scopus 로고    scopus 로고
    • Establishment and characterization of an immortalized Z310 choroidal epithelial cell line from murine choroid plexus
    • Zheng, W., and Zhao, Q. (2002). Establishment and characterization of an immortalized Z310 choroidal epithelial cell line from murine choroid plexus. Brain Res. 958, 271-380.
    • (2002) Brain Res , vol.958 , pp. 271-380
    • Zheng, W.1    Zhao, Q.2
  • 68
    • 0033606416 scopus 로고    scopus 로고
    • Alteration of iron homeostasis following chronic exposure to manganese in rats
    • Zheng, W., Zhao, Q., Slavkovich, V., Aschner, M., and Graziano, J. H. (1999). Alteration of iron homeostasis following chronic exposure to manganese in rats. Brain Res. 833, 125-132.
    • (1999) Brain Res , vol.833 , pp. 125-132
    • Zheng, W.1    Zhao, Q.2    Slavkovich, V.3    Aschner, M.4    Graziano, J.H.5
  • 69
    • 0030844529 scopus 로고    scopus 로고
    • hCTR1: A human gene for copper uptake identified by complementation in yeast
    • Zhou, B., and Gitschier, J. (1997). hCTR1: A human gene for copper uptake identified by complementation in yeast. Proc. Natl. Acad. Sci. U.S.A. 94, 7481-7486.
    • (1997) Proc. Natl. Acad. Sci. U.S.A , vol.94 , pp. 7481-7486
    • Zhou, B.1    Gitschier, J.2


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