Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro

Brain Research

Volumn 1097, Issue 1, 2006, Pages 1-10

  Wang, Xueqian ^a   Li, Guojun Jane ^a   Zheng, Wei ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Blood CSF barrier; Choroid plexus; Divalent metal transporter 1; Iron responsive element; Manganese; Z310 cell

Indexed keywords

MANGANESE; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NUCLEAR RNA;

ANIMAL CELL; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; CELL CULTURE; CELL IMMORTALIZATION; CHOROID PLEXUS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEGENERATIVE DISEASE; GEL MOBILITY SHIFT ASSAY; IMMUNOCYTOCHEMISTRY; IRON TRANSPORT; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSONISM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; BLOOD-BRAIN BARRIER; CATION TRANSPORT PROTEINS; CELL LINE, TRANSFORMED; CHOROID PLEXUS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; IRON-BINDING PROTEINS; MANGANESE; RATS; RNA, MESSENGER; UP-REGULATION;

EID: 33745907562     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.04.046     Document Type: Article

References (48)

1. Addess K.J., Basilion J.P., Klausner R.D., Rouault T.A., and Pardi A. Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins. J. Mol. Biol. 274 (1997) 72-83
2. Andrews N.C. The iron transporter DMT1. Int. J. Biochem. Cell Biol. 31 (1999) 991-994
3. Aschner M., Vrana K.E., and Zheng W. Manganese uptake and distribution in the central nervous system (CNS). Neurotoxicology 20 (1999) 173-180
4. Bradbury M.W. Transport of iron in the blood-brain-cerebrospinal fluid system. J. Neurochem. 69 (1997) 443-454
5. Burdo J.R., Menzies S.L., Simpson I.A., Garrick L.M., Garrick M.D., Dolan K.G., Haile D.J., Beard J.L., and Connor J.R. Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J. Neurosci. Res. 66 (2001) 1198-1207
6. Chen J.Y., Tsao G.C., Zhao Q., and Zheng W. Differential cytotoxicity of Mn(II) and Mn(III): special reference to mitochondrial [Fe-S] containing enzymes. Toxicol. Appl. Pharmacol. 175 (2001) 160-168
7. Choudhuri S., Cherrington N.J., Li N., and Klaassen C.D. Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats. Drug Metab. Dispos. 31 (2003) 1337-1345
8. Danzi S., Ojamaa K., and Klein I. Triiodothyronine-mediated myosin heavy chain gene transcription in the heart. Am. J. Physiol. Heart. Circ. Physiol. 284 (2003) H2255-H2262
9. Deane R., Zheng W., and Zlokovic B.V. Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J. Neurochem. 88 (2004) 813-820
10. Eisenstein R.S., and Ross K.L. Novel roles for iron regulatory proteins in the adaptive response to iron deficiency. J. Nutr. 133 (2003) 1510S-1516S
11. Ferguson C.J., Wareing M., Ward D.T., Green R., Smith C.P., and Riccardi D. Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am. J. Physiol. Renal. Physiol. 280 (2001) F803-F814
12. Fleming M.D., Trenor III C.C., Su M.A., Foernzler D., Beier D.R., Dietrich W.F., and Andrews N.C. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat. Genet. 16 (1997) 383-386
13. Fleming M.D., Romano M.A., Su M.A., Garrick L.M., Garrick M.D., and Andrews N.C. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 1148-1153
14. Georgieff M.K., Wobken J.K., Welle J., Burdo J.R., and Connor J.R. Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta. Placenta 21 (2000) 799-804
15. Gruenheid S., Cellier M., Vidal S., and Gros P. Identification and characterization of a second mouse Nramp gene. Genomics 25 (1995) 514-525
16. Gruenheid S., Canonne-Hergaux F., Gauthier S., Hackam D.J., Grinstein S., and Gros P. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J. Exp. Med. 189 (1999) 831-841
17. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan J.L., and Hediger M.A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (1997) 482-488
18. Gunshin H., Allerson C.R., Polycarpou-Schwarz M., Rofts A., Rogers J.T., Kishi F., Hentze M.W., Rouault T.A., Andrews N.C., and Hediger M.A. Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett. 509 (2001) 309-316
19. Guo B., Phillips J.D., Yu Y., and Leibold E.A. Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. J. Biol. Chem. 270 (1995) 21645-21651
20. Ke Y., Chen Y.Y., Chang Y.Z., Duan X.L., Ho K.P., Jiangde H., Wang K., and Qian Z.M. Post-transcriptional expression of DMT1 in the heart of rat. J. Cell. Physiol. 196 (2003) 124-130
21. Kishi F., and Tabuchi M. Complete nucleotide sequence of human NRAMP2 cDNA. Mol. Immunol. 34 (1997) 839-842
22. Klausner R.D., Rouault T.A., and Harford J.B. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 72 (1993) 19-28
23. Knutson M., Menzies S., Connor J., and Wessling-Resnick M. Developmental, regional, and cellular expression of SFT/UbcH5A and DMT1 mRNA in brain. J. Neurosci. Res. 76 (2004) 633-641
24. Konarska M.M., and Sharp P.A. Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs. Cell 46 (1986) 845-855
25. Lee P.L., Gelbart T., West C., Halloran C., and Beutler E. The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms. Blood Cells Mol. Dis. 24 (1998) 199-215
26. Levy J.E., Jin O., Fujiwara Y., Kuo F., and Andrews N.C. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat. Genet. 21 (1999) 396-399
27. Li G.J., Zhao Q., and Zheng W. Alteration at translational but not transcriptional level of transferrin receptor expression following manganese exposure at the blood-CSF barrier in vitro. Toxicol. Appl. Pharmacol. 205 (2005) 188-200
28. Lin E., Graziano J.H., and Freyer G.A. Regulation of the 75-kDa subunit of mitochondrial complex I by iron. J. Biol. Chem. 276 (2001) 27685-27692
29. Liu J., Walker N., and Waalkes M.P. Hybridization buffer systems impact the quality of filter array data. J. Pharmacol. Toxicol. Methods 50 (2004) 67-71
30. Liu J., Xie Y., Ward J.M., Diwan B.A., and Waalkes M.P. Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic. Toxicol. Sci. 77 (2004) 249-257
31. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
32. Meyron-Holtz E.G., Ghosh M.C., and Rouault T.A. Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo. Science 306 (2004) 2087-2090 (see comment)
33. Miller D.S. Confocal imaging of xenobiotic transport across the choroid plexus. Adv. Drug Delivery Rev. 56 (2004) 1811-1824
34. Moos T., and Morgan E.H. The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain. J. Neurochem. 88 (2004) 233-245
35. Reaney S.H., and Smith D.R. Manganese oxidation state mediates toxicity in PC12 cells. Toxicol. Appl. Pharmacol. 205 (2005) 271-281
36. Roth J.A., Horbinski C., Feng L., Dolan K.G., Higgins D., and Garrick M.D. Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells. J. Neurosci. 20 (2000) 7595-7601
37. Rouault T.A. Systemic iron metabolism: a review and implications for brain iron metabolism. Pediatr. Neurol. 25 (2001) 130-137
38. Rouault T.A., and Klausner R.D. The impact of oxidative stress on eukaryotic iron metabolism. EXS 77 (1996) 183-197
39. Siddappa A.J., Rao R.B., Wobken J.D., Leibold E.A., Connor J.R., and Georgieff M.K. Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain. J. Neurosci. Res. 68 (2002) 761-775
40. Siddappa A.J., Rao R.B., Wobken J.D., Casperson K., Leibold E.A., Connor J.R., and Georgieff M.K. Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain. Pediatr. Res. 53 (2003) 800-807
41. Su M.A., Trenor C.C., Fleming J.C., Fleming M.D., and Andrews N.C. The G185R mutation disrupts function of the iron transporter Nramp2. Blood 92 (1998) 2157-2163
42. Takeda A., Takatsuka K., Sotogaku N., and Oku N. Influence of iron-saturation of plasma transferrin in iron distribution in the brain. Neurochem. Int. 41 (2002) 223-228
43. Vidal S., Belouchi A.M., Cellier M., Beatty B., and Gros P. Cloning and characterization of a second human NRAMP gene on chromosome 12q13. Mamm. Genome 6 (1995) 224-230
44. Walker N.J. Real-time and quantitative PCR: applications to mechanism-based toxicology. J. Biochem. Mol. Toxicol. 15 (2001) 121-127
45. Zheng W., and Zhao Q. Iron overload following manganese exposure in cultured neuronal, but not neuroglial cells. Brain Res. 897 (2001) 175-179
46. Zheng W., and Zhao Q. Establishment and characterization of an immortalized Z310 choroidal epithelial cell line from murine choroid plexus. Brain Res. 958 (2002) 371-380
47. Zheng W., Ren S., and Graziano J.H. Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity. Brain Res. 799 (1998) 334-342
48. Zheng W., Zhao Q., Slavkovich V., Aschner M., and Graziano J.H. Alteration of iron homeostasis following chronic exposure to manganese in rats. Brain Res. 833 (1999) 125-132