Relative contribution of CTR1 and DMT1 in copper transport by the blood-CSF barrier: Implication in manganese-induced neurotoxicity

Toxicology and Applied Pharmacology

Volumn 260, Issue 3, 2012, Pages 285-293

  Zheng, Gang ^a,b   Chen, Jingyuan ^b   Zheng, Wei ^a  

^a PURDUE UNIVERSITY   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Choroid plexus; Copper; Cu transporter 1 (CTR1); Divalent metal transporter 1 (DMT1); IZCTR1 iZDMT1; Manganese

Indexed keywords

COPPER; MANGANESE; MESSENGER RNA; PROTEIN; PROTEIN CTR1; PROTEIN DMT1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; CELL IMMORTALIZATION; CELL LINE; CONTROLLED STUDY; COPPER BLOOD LEVEL; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INDUCTION;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CATION TRANSPORT PROTEINS; CELL LINE; CHOROID PLEXUS; COPPER; EPITHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; MANGANESE; MICE; RATS; RNA, MESSENGER; TETRACYCLINE;

ANIMALIA;

EID: 84859988715     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.03.006     Document Type: Article

References (40)

1. Aschner M., Nass R., Guilarte T.R., Schneider J.S., Zheng W. Manganese: recent advances in understanding its transport and neurotoxicity. Toxicol. Appl. Pharmacol. 2007, 221:131-147.
2. Beaudoin J., Thiele D.J., Labbé S., Puig S. Dissection of the relative contribution of the Schizosaccharomyces pombe Ctr4 and Ctr5 proteins to the copper transport and cell surface delivery functions. Microbiology 2011, 157:1021-1031.
3. Bertinato J., Swist E., Plouffe L.J., Brooks S.P., L'abbé M.R. Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells. Biochem. J. 2008, 409:731-740.
4. Boll M.C., Alcaraz-Zubeldia M., Montes S., Rios C. Free copper, ferroxidase and SOD1 activities, lipid peroxidation and NO(x) content in the CSF. A different marker profile in four neurodegenerative diseases. Neurochem. Res. 2008, 33:1717-1723.
5. Choi B.S., Zheng W. Copper transport to the brain by the blood-brain barrier and blood-CSF barrier. Brain Res. 2009, 1248:14-21.
6. Crossgrove J.S., Zheng W. Manganese toxicity upon overexposure. NMR Biomed. 2004, 17:544-553.
7. Deibel M.A., Ehmann W.D., Markesbery W.R. Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress. J. Neurol. Sci. 1996, 143:137-142.
8. Gaggelli E., Kozlowski H., Valensin D., Valensin G. Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis). Chem. Rev. 2006, 106:1995-2044.
9. Greenough M.A., Volitakis I., Li Q.X., Laughton K., Evin G., Ho M., Dalziel A.H., Camakaris J., Bush A.I. Presenilins promote the cellular uptake of copper and zinc and maintain Cu-chaperone of sod1-dependent Cu/Zn superoxide dismutase activity. J. Biol. Chem. 2011, 286:9776-9786.
10. Gruenheid S., Cellier M., Vidal S., Gros P. Identification and characterization of a second mouse Nramp gene. Genomics 1995, 25:514-525.
11. Guilarte T.R., Chen M.K. Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects. NeuroToxicology 2007, 28:1147-1152.
12. Guilarte T.R., Chen M.K., McGlothan J.L., Verina T., Wong D.F., Zhou Y., Alexander M., Rohde C.A., Syversen T., Decamp E., Koser A.J., Fritz S., Gonczi H., Anderson D.W., Schneider J.S. Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates. Exp. Neurol. 2006, 202:381-390.
13. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan J.L., Hediger M.A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997, 388:482-488.
14. Horn D., Barrientos A. Mitochondrial copper metabolism and delivery to cytochrome c oxidase. IUBMB Life 2008, 60:421-429.
15. Hozumi I., Hasegawa T., Honda A., Ozawa K., Hayashi Y., Hashimoto K., Yamada M., Koumura A., Sakurai T., Kimura A., Tanaka Y., Satoh M., Inuzuka T. Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J. Neurol. Sci. 2011, 303:95-99.
16. Jiang Y., Zheng W., Long L., Zhao W., Li X., Mo X., Lu J., Fu X., Li W., Liu S., Long Q., Huang J., Pira E. Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: search for biomarkers of manganese exposure. Neurotoxicology 2007, 28:126-135.
17. Jiménez-Jiménez F.J., Molina J.A., Aguilar M.V., Meseguer I., Mateos-Vega C.J., González-Muñoz M.J., de Bustos F., Martínez-Salio A., Ortí-Pareja M., Zurdo M., Martínez-Para M.C. Cerebrospinal fluid levels of transition metals in patients with Parkinson's disease. J. Neural Transm. 1998, 105:497-505.
18. Kuo Y.M., Gybina A.A., Pyatskowit J.W., Gitschier J., Prohaska J.R. Copper transport protein (Ctr1) levels in mice are tissue specific and dependent of copper status. J. Nutr. 2006, 136:21-26.
19. Lai J.C., Minski M.J., Chan A.W., Leung T.K., Lim L. Manganese mineral interactions in brain. Neurotoxicology 1999, 20:433-444.
20. Li G.J., Zhao Q., Zheng W. Alteration at translational but not transcriptional level of transferrin receptor expression following manganese exposure at the blood-CSF barrier in vitro. Toxicol. Appl. Pharmacol. 2005, 205:188-200.
21. Liu Y., Pilankatta R., Hatori Y., Lewis D., Inesi G. Comparative features of copper ATPases ATP7A and ATP7B heterologously expressed in COS-1 cells. Biochemistry 2010, 49:10006-10012.
22. 64Cu using a biomedical cyclotron. Nucl. Med. Biol. 1997, 24:35-43.
23. Mergler D., Baldwin M. Early manifestations of manganese neurotoxicity in humans: an update. Environ. Res. 1997, 73:92-100.
24. Pall H.S., Williams A.C., Blake D.R., Lunec J., Gutteridge J.M., Hall M., Taylor A. Raised cerebrospinal-fluid copper concentration in Parkinson's disease. Lancet 1987, 2:238-241.
25. Pena M.M., Puig S., Thiele D.J. Characterization of the Saccharomyces cerevisiae high affinity copper transporter Ctr3. J. Biol. Chem. 2000, 275:33244-33251.
26. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001, 29:e45.
27. Rossi L., Lombardo M.F., Ciriolo M.R., Rotilio G. Mitochondrial dysfunction in neurodegenerative diseases associated with copper imbalance. Neurochem. Res. 2004, 29:493-504. Review.
28. Samimi G., Katano K., Holzer A.K., Safaei R., Howell S.B. Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B. Mol. Pharmacol. 2004, 66:25-32.
29. Sparks D.L., Schreurs B.G. Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:11065-11069.
30. Strausak D., Mercer J.F., Dieter H.H., Stremmel W., Multhaup G. Copper in disorders with neurological symptoms: Alzheimer's, Menkes, and Wilson diseases. Brain Res. Bull. 2001, 55:175-185.
31. Waggoner D.J., Bartnikas T.B., Gitlin J.D. The role of copper in neurodegenerative disease. Neurobiol. Dis. 1999, 6:221-230. Review.
32. Wang X., Li G.J., Zheng W. Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro. Brain Res. 2006, 1097:1-10.
33. Wang D., Du X., Zheng W. Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders. Toxicol. Lett. 2008, 176:40-47.
34. Wang X., Li G.J., Zheng W. Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier: effect of manganese exposure. Exp. Biol. Med. (Maywood) 2008, 233:1561-1571.
35. Wang X., Miller D.S., Zheng W. Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron. Toxicol. Appl. Pharmacol. 2008, 230:167-174.
36. Zheng W. Toxicology of choroid plexus: special reference to metal-induced neurotoxicities. Microsc. Res. Tech. 2001, 52:89-103.
37. Zheng W., Monnot A.D. Regulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseases. Pharmacol. Ther. 2012, 133:177-188.
38. Zheng W., Zhao Q. Establishment and characterization of an immortalized Z310 choroidal epithelial cell line from murine choroid plexus. Brain Res. 2002, 958:371-380.
39. Zheng W., Aschner M., Ghersi-Egea J.F. Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol. Appl. Pharmacol. 2003, 192:1-11.
40. Zheng W., Jiang Y.M., Zhang Y., Jiang W., Wang X., Cowan D.M. Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague-Dawley rats. Neurotoxicology 2009, 30:240-248.