Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier:Effect of manganese exposure

Experimental Biology and Medicine

Volumn 233, Issue 12, 2008, Pages 1561-1571

  Wang, Xueqian ^a,c   Li, G Jane ^b   Zheng, Wei ^a  

^a PURDUE UNIVERSITY   (United States)

^b Beijing Municipal Health Bureau   (China)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Blood CSF barrier; Choroid plexus; In vitro transwell model; Iron; Manganese; Ventriculo cisternal perfusion

Indexed keywords

ANTIBODY; FERROPORTIN; IRON; MANGANESE; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; SMALL INTERFERING RNA; TRANSFERRIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; BRAIN PERFUSION; CELL CULTURE; CELL LINE; CELL STRAIN Z310; CELL TRANSPORT; CEREBROSPINAL FLUID; CHOROID PLEXUS; CONTROLLED STUDY; DRUG TRANSPORT; EPITHELIUM CELL; HOMEOSTASIS; IN VIVO STUDY; INCUBATION TIME; IRON TRANSPORT; LONG TERM EXPOSURE; MALE; NONHUMAN; PROTEIN EXPRESSION; RADIOACTIVITY; RAT; ANIMAL; BIOLOGICAL MODEL; BLOOD; BLOOD BRAIN BARRIER; IMMUNOHISTOCHEMISTRY; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE, TRANSFORMED; CEREBROSPINAL FLUID; CHOROID PLEXUS; EPITHELIAL CELLS; IMMUNOHISTOCHEMISTRY; IRON; MALE; MANGANESE; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 58749083614     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0803-RM-104     Document Type: Article

References (47)

1. Zheng W, Aschner M, Ghersi-Egea JF. Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol Appl Pharmacol 192:1-11, 2003.
2. Jellinger KA. The role of iron in neurodegeneration: prospects for pharmacotherapy of Parkinson's disease. Drugs Aging 14:115-140, 1999.
3. Holtz WA, Turetzky JM, Jong YJ, O'Malley KL. Oxidative stress-triggered unfolded protein response is upstream of intrinsic cell death evoked by parkinsonian mimetics. J Neurochem 99:54-69, 2006.
4. Shinde S, Pasupathy K. Respiratory-chain enzyme activities in isolated mitochondria of lymphocytes from patients with Parkinson's disease:preliminary study. Neurol India 54:390-393, 2006.
5. Szeto HH. Mitochondria-targeted peptide antioxidants: novel neuro-protective agents. Aaps J 8:E521-531, 2006.
6. Moos T. Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system. J Comp Neurol 375:675-692, 1996.
7. Berg D, Gerlach M, Youdim MB, Double KL, Zecca L, Riederer P, Becker G. Brain iron pathways and their relevance to Parkinson's disease. J Neurochem 79:225-236, 2001.
8. Zheng W, Zhao Q, Slavkovich V, Aschner M, Graziano JH. Alteration of iron homeostasis following chronic exposure to manganese in rats. Brain Res 833:125-132, 1999.
9. Li GJ, Choi BS, Wang X, Liu J, Waalkes MP, Zheng W. Molecular mechanism of distorted iron regulation in the blood-CSF barrier and regional blood-brain barrier following in vivo subchronic manganese exposure. Neurotoxicology 27:737-744, 2006.
10. Zheng W, Zhao Q. Iron overload following manganese exposure in cultured neuronal, but not neuroglial cells. Brain Res 897:175-179, 2001.
11. Li GJ, Zhao Q, Zheng W. Alteration at translational but not transcriptional level of transferrin receptor expression following manganese exposure at the blood-CSF barrier in vitro. Toxicol Appl Pharmacol 205:188-200, 2005.
12. Wang X, Li GJ, Zheng W. Upregulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vitro. Brain Res 1097:1-10, 2006.
13. Bradbury MW. Transport of iron in the blood-brain-cerebrospinal fluid system. J Neurochem 69:443-154, 1997.
14. Moos T, Morgan EH. Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid. J Neurosci Res 54:486-494, 1998.
15. Ueda F, Raja KB, Simpson RJ, Trowbridge IS, Bradbury MW. Rate of 59Fe uptake into brain and cerebrospinal fluid and the influence thereon of antibodies against the transferrin receptor. J Neurochem 60:106-113, 1993.
16. Deane R, Zheng W, Zlokovic BV. Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J Neurochem 88:813-820, 2004.
17. Li CY, Watkins JA, Glass J. The H(+)-ATPase from reticulocyte endosomes reconstituted into liposomes acts as an iron transporter. J Biol Chem 269:10242-10246, 1994.
18. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482-488, 1997.
19. Tabuchi M, Tanaka N, Nishida-Kitayama J, Ohno H, Kishi F. Alternative splicing regulates the subcellular localization of divalent metal transporter 1 isoforms. Mol Biol Cell 13:4371-4387, 2002.
20. Qian ZM, Shen X. Brain iron transport and neurodegeneration. Trends Mol Med 7:103-108, 2001.
21. Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts:molecular control of mammalian iron metabolism. Cell 117:285-297, 2004.
22. Wang X, Miller DS, Zheng W. Intracellular trafficking of metal transporters in intact rat choroid plexus following in vitro treatment of manganese or iron. Toxicol Appl Pharmacol (in press).
23. Zheng W, Zhao Q, Graziano JH. Primary culture of choroidal epithelial cells: characterization of an in vitro model of blood-CSF barrier. In Vitro Cell Dev Biol Anim 34:40-45, 1998.
24. Zheng W, Zhao Q. The blood-CSF barrier in culture. Development of a primary culture and transepithelial transport model from choroidal epithelial cells. Methods Mol Biol 188:99-114, 2002.
25. Zheng W, Zhao Q. Establishment and characterization of an immortalized Z310 choroidal epithelial cell line from murine choroid plexus. Brain Res 958:371-380, 2002.
26. Shi LZ, Zheng W. Establishment of an in vitro brain barrier epithelial transport system for pharmacological and toxicological study. Brain Res 1057:37-48, 2005.
27. Al-Sarraf H, Philip L. Effect of hypertension on the integrity of blood brain and blood CSF barriers, cerebral blood flow and CSF secretion in the rat. Brain Res 975:179-188, 2003.
28. Al-Sarraf H, Philip L. Increased brain uptake and CSF clearance of 14C-glutamate in spontaneously hypertensive rats. Brain Res 994:181-187, 2003.
29. Strazielle N, Ghersi-Egea JF. Demonstration of a coupled metabolism-efflux process at the choroid plexus as a mechanism of brain protection toward xenobiotics. J Neurosci 19:6275-6289, 1999.
30. Crossgrove JS, Li GJ, Zheng W. The choroid plexus removes beta-amyloid from brain cerebrospinal fluid. Exp Biol Med (Maywood) 230:771-776, 2005.
31. Faucheux BA, Nillesse N, Damier P, Spik G, Mouatt-Prigent A, Pierce A, Leveugle B, Kubis N, Hauw JJ, Agid Y. Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease. Proc Natl Acad Sci U S A 92:9603-9607, 1995.
32. Qian ZM, Wang Q. Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders. Brain Res Brain Res Rev 27:257-267, 1998.
33. Malecki EA, Devenyi AG, Beard JL, Connor JR. Existing and emerging mechanisms for transport of iron and manganese to the brain. J Neurosci Res 56:113-122, 1999.
34. Bannon DI, Abounader R, Lees PS, Bressler JP. Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells. Am J Physiol Cell Physiol 284:C44-50, 2003.
35. He L, Girijashanker K, Dalton TP, Reed J, Li H, Soleimani M, Nebert DW. ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties. Mol Pharmacol 70:171-180, 2006.
36. Oates PS, Morgan EH. Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents. Am J Physiol 270:G826-832, 1996.
37. Garrick LM, Dolan KG, Romano MA, Garrick MD. Non-transferrin-bound iron uptake in Belgrade and normal rat erythroid cells. J Cell Physiol 178:349-358, 1999.
38. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, Zon LI. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403:776-781, 2000.
39. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, Simpson RJ. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5:299-309, 2000.
40. Wu LJ, Leenders AG, Cooperman S, Meyron-Holtz E, Smith S, Land W, Tsai RY, Berger UV, Sheng ZH, Rouault TA. Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier. Brain Res 1001:108-117, 2004.
41. Aisen P, Wessling-Resnick M, Leibold EA. Iron metabolism. Curr Opin Chem Biol 3:200-206, 1999.
42. Thompson KJ, Shoham S, Connor JR. Iron and neurodegenerative disorders. Brain Res Bull 55:155-164, 2001.
43. Ellingsen DG, Haug E, Ulvik RJ, Thomassen Y. Iron status in manganese alloy production workers. J Appl Toxicol 23:239-247,2003.
44. Powers KM, Smith-Weller T, Franklin GM, Longstreth WT, Swanson PD, Checkoway H. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 60:1761-1766,2003.
45. Lu L, Zhang LL, Li GJ, Guo W, Liang W, Zheng W. Alteration of serum concentrations of manganese, iron, ferritin, and transferrin receptor following exposure to welding fumes among career welders.Neurotoxicology 26:257-265, 2005.
46. Chua AC, Morgan EH. Effects of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat. Biol Trace Elem Res 55:39-54, 1996.
47. Li GJ, Zhang LL, Lu L, Wu P, Zheng W. Occupational exposure to welding fume among welders: alterations of manganese, iron, zinc, copper, and lead in body fluids and the oxidative stress status. J Occup Environ Med 46:241-248, 2004.