Regulation of brain copper homeostasis by the brain barrier systems: Effects of Fe-overload and Fe-deficiency

Toxicology and Applied Pharmacology

Volumn 256, Issue 3, 2011, Pages 249-257

  Monnot, Andrew D ^a   Behl, Mamta ^a   Ho, Sanna ^a   Zheng, Wei ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Blood brain barrier; Blood CSF barrier; Choroid plexus; Copper; In situ perfusion; In vitro Transwell model; Iron; Ventriculo cisternal perfusion

Indexed keywords

COPPER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CEREBROSPINAL FLUID; CHOROID PLEXUS; CONTROLLED STUDY; EPITHELIUM CELL; HOMEOSTASIS AND REGULATION; IRON DEFICIENCY; IRON OVERLOAD; MALE; NONHUMAN; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN CHEMISTRY; CHOROID PLEXUS; COPPER; HOMEOSTASIS; IRON; IRON COMPOUNDS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RATTUS;

EID: 80855143780     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.02.003     Document Type: Article

References (43)

1. Arredondo M., Nunez M.T. Iron and copper metabolism. Mol. Aspects Med. 2005, 26:313-327.
2. Arredondo M., Uauy R., González M. Regulation of copper uptake and transport in intestinal cell monolayers by acute and chronic copper exposure. Biochim. Biophys. Acta 2000, 1474(2):169-176.
3. Arredondo M., Martinez R., Nunez M.T., Ruz M., Olivares M. Inhibition of iron and copper uptake by iron, copper, and zinc. Biol. Res. 2006, 39:95-102.
4. Behl M., Zhang Y., Monnot A.D., Zheng W., Jiang W. Increased β-amyloid levels in the choroid plexus following lead exposure and the involvement of low density lipoprotein receptor protein-1. Toxicol. Appl. Pharmacol. 2009, 240:245-254.
5. Carlson E.S., Magid R., Petryk P., Georgieff M.K. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Brain Res. 2008, 1283:75-83.
6. Choi B.S., Zheng W. Copper transport to the brain by the blood-brain barrier and blood-CSF barrier. Brain Res. 2009, 1258:14-21.
7. Collins J. Gene chip analyses reveal differential genetic responses to iron deficiency in rat duodenum and jejunum. Biol. Res. 2006, 39(1):25-37.
8. Crossgrove J.S., Li G.J., Zheng W. The choroid plexus removes beta-amyloid from the cerebrospinal fluid. Exp. Biol. Med. 2005, 230(10):771-776.
9. Crowe A., Morgan E.H. Iron and copper interact during their uptake and deposition in the brain and other organs of developing rats exposed to dietary excess of the two metals. J. Nutr. 1996, 126(1):193-194.
10. Dallman P.R., Refino C., Yland M.J. Sequence of development of iron deficiency in the rat. Am. J. Clin. Nutr. 1982, 35(4):671-677.
11. Deane R., Bradbury M.W. Transport of lead-203 at the blood-brain barrier during short cerebrovascular perfusion with saline in the rat. J. Neurochem. 1990, 54:905-914.
12. Deane R., Zheng W., Zlokovic B.V. Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J. Neurochem. 2004, 88:813-820.
13. Erikson K.M., Syversen T., Steinnes E., Aschner M. Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency. J. Nutr. Biochem. 2004, 15(6):335-341.
14. Fairweather-Tait S.J. Iron nutrition in the UK: getting the balance right. Proc. Nutr. Soc. 2004, 63:519-528.
15. Gaggelli E., Kozlowski H., Valensin D., Valensin G. Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis). Chem. Rev. 2006, 106(6):1995-2044.
16. Gambling L., McArdle H.J. Iron, copper, and fetal development. Proc. Nutr. Soc. 2004, 63:553-562.
17. Garcia S.J., Gellein K., Syversen T., Aschner M. Iron deficient and manganese supplemented diets alter metals and transporter in the developing rat brain. Toxicol. Sci. 2007, 95(1):205-214.
18. Garrick M.D., Nunez M.T., Olivares M., Harris E.D. Parallels and contrasts between iron and copper metabolism. Biometals 2003, 16:1-8.
19. Linder M.C., Zerounian N.R., Moriya M., Malpe R. Iron and copper homeostasis and intestinal absorption using the Caco2 cell model. Biometals 2003, 16:145-160.
20. 64Cu using a biomedical cyclotron. Nucl. Med. Biol. 1997, 24:35-43.
21. Murray-Kolb L.E., Beard J.L. Iron treatment normalizes cognitive functioning in young women. Am. J. Clin. Nutr. 2007, 85:778-787.
22. 14C-mannitol using the rat in situ brain perfusion technique. Brain Res. Dev. Brain Res. 1995, 87:69-76.
23. Ryu D.Y., Lee S.J., Park D.W., Choi B.S., Klaassen C.D., Park J.D. Dietary iron regulates intestinal cadmium absorption through iron transporters in rats. Toxicol. Lett. 2004, 152:19-29.
24. Salustri C., Barbati G., Ghidoni R., Quintiliani L., Ciappina S., Binetti G., Squitti R. Is cognitive function linked to serum free copper levels? A cohort study in a normal population. Clin. Neurophysiol. 2010, 121(4):459-460. Apr.
25. Sharp P. The molecular basis of copper and iron interactions. Proc. Nutr. Soc. 2004, 63:563-569.
26. Shi L.Z., Zheng W. Establishment of an in vitro brain barrier epithelial transport system for pharmacological and toxicological study. Brain Res. 2005, 1057:37-48.
27. Shi L.Z., Zheng W. Early lead exposure increases the leakage of the blood-cerebrospinal fluid barrier, in vitro. Hum. Exp. Toxicol. 2007, 26:159-167.
28. Smith Q.R. Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system. Pharm. Biotechnol. 1996, 8:285-307.
29. Sparks D.L., Schreurs B.G. Trace amounts of copper in water induce β-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. Proc. Natl Acad. Sci. USA 2003, 100(19):11065-11069.
30. Stuerenburg H.J. CSF copper concentrations, blood-brain barrier function, and ceruloplasmin synthesis during the treatment of Wilson's disease. J. Neural Transm. 2000, 107:321-329.
31. Takasato Y., Smith Q.R. An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am. J. Physiol. 1984, 247:H484-H493.
32. Triguero D., Buciak J., Pardridge W.M. Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J. Neurochem. 1990, 54:1882-1888.
33. Wang X., Li G.J., Zheng W. Up regulation of DMT1 expression in choroidal epithelia of the blood-CSF barrier following manganese exposure in vivo. Brain Res. 2006, 1097:1-10.
34. Wang X., Li G.J., Zheng W. Efflux of iron from the cerebrospinal fluid to the blood at the blood-CSF barrier: effect of manganese exposure. Exp. Biol. Med. 2008, 233(12):1561-1571.
35. World Health Organization Micronutrient deficiencies Retrieved from. http://www.who.int/nutrition/topics/ida/en/index.html.
36. Youdim M.B.H. Brain iron deficiency and excess; cognitive impairment and neurodegeneration with involvement of striatum and hippocampus. Neurotox. Res. 2008, 14(1):45-56.
37. Zheng W. The choroid plexus and metal toxicities. Toxicology of Metals 1996, 609-626. CRC Press, New York. L.W. Chang (Ed.).
38. Zheng W. Toxicology of choroid plexus: special reference to metal-induced neurotoxicities. Microsc. Res. Tech. 2001, 52:89-103.
39. Zheng W. Neurotoxicology of the brain barrier system: new implications. J. Toxicol. Clin. Toxicol. 2001, 39:711-719.
40. Zheng W., Perry D.F., Nelson D.L., Aposhian H.V. Protection of cerebrospinal fluid against toxic metals by the choroid plexus. FASEB J. 1991, 5:2188-2193.
41. Zheng W., Zhao Q., Graziano J.H. Primary culture of choroidal epithelial cells: characterization of an in vitro model of blood-CSF barrier. In Vitro Cell. Dev. Anim. 1998, 34:40-45.
42. Zheng W., Aschner M., Ghersi-Egea J.F. Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol. Appl. Pharmacol. 2003, 192:1-11.
43. Zlokovic B.V., Begley D.J., Djuricic B.M., Mitrovic D.M. Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid. J. Neurochem. 1986, 46:1444-1451.