Islet number rather than islet size is a major determinant of α- And β-Cell mass in humans

Journal of Clinical Endocrinology and Metabolism

Volumn 99, Issue 5, 2014, Pages 1733-1740

  Kou, Kinsei ^a   Saisho, Yoshifumi ^a   Sato, Seiji ^a   Yamada, Taketo ^a   Itoh, Hiroshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; HEMOGLOBIN A1C; INSULIN;

ADULT; AGED; ARTICLE; BODY MASS; CELL SIZE; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; ORGAN SIZE; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ADULT; AGED; CELL COUNT; FEMALE; GLUCAGON-SECRETING CELLS; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; ORGAN SIZE; PANCREAS;

EID: 84899905701     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-3731     Document Type: Article

References (40)

1. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizz a RA, Butler PC.-Cell deficit and increased-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52:102-110.
2. Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC. Sust ained-cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration Diabetologia. 2005;48:2221-2228.
3. Danobeitia JS, Fernandez LA. Clinical islet transplantation: recent advances in the field. Clin Transpl. 2012:193-200.
4. Gruessner RW, Gruessner AC. The current state of pancreas transplantation. Nat Rev Endocrinol. 2013;9(9):555-562.
5. Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004;429:41-46.
6. Manesso E, Toffolo GM, Saisho Y, et al. Dynamics of-cell turnover: evidence for-cell turnover and regeneration from sources of-cells other than-cell replication in the HIP rat. Am J Physiol Endocrinol Metab. 2009;297:E323-E330.
7. Saisho Y, Manesso E, Butler AE, et al. Ongoing-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Diabetes. 2011;60:848-856.
8. Inada A, Nienaber C, Katsuta H, et al. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci USA. 2008;105:19915-19919.
9. Butler AE, Cao-Minh L, Galasso R, et al. Adaptive changes in pancreatic-cell fractional area and-cell turnover in human pregnancy. Diabetologia. 2010;53:2167-2176.
10. Le Bacquer O, Kerr-Conte J, Gargani S, et al. TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals. Diabetologia. 2012;55:2677-2681.
11. Kou K, Saisho Y, Satoh S, Yamada T, Itoh H. Change in-cell mass in Japanese non-diabetic obese individuals. J Clin Endocrinol Metab. 2013;98(9):3724-3730.
12. Committee on t he Standardization of Diabetes Mellitus-Related Laboratory Testing of Japan Diabetes Society International clinical harmonization of glycated hemoglobin in Japan: from Japan Diabetes Society to National Glycohemoglobin Standardization Program values . Diabetol Int 2012 3 8-10.
13. Saisho Y, Butler AE, Manesso E, Elashoff D, Rizza RA, Butler PC.-Cell mass and turnover in humans: effects of obesity and aging. Diabetes Care. 2013;36:111-117.
14. Saisho Y, Butler AE, Meier JJ, et al. Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes. Clin Anat. 2007; 20:933-942.
15. Xu X, D'Hoker J, Stange G, et al.-Cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell. 2008;132:197-207.
16. Bruning JC,WinnayJ, Bonner-Weir S, Taylor SI, Accili D,KahnCR. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell. 1997;88:561-572.
17. B utler PC, Meier JJ, Butler AE, Bhushan A. The replication of-cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab. 2007;3:758-768.
18. Rolin B, Larsen MO, Gotfredsen CF, et al. The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases-cell mass in diabetic mice. Am J Physiol Endocrinol Metab. 2002;283:E745-E752.
19. Lamont BJ, Li Y, Kwan E, Brown TJ, Gaisano H, Drucker DJ. Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. J Clin Invest. 2012;122:388-402.
20. Bunck MC, Corner A, Eliasson B, et al. Effects of exenatide on measures of-cell function after 3 years in metformin-treated patients with type 2 diabetes. Diabetes Care. 2011;34:2041-2047.
21. Jonsson A, Ladenvall C, Ahluwalia TS, et al. Effects of common genetic variants associated with type 2 diabetes and glycemic traits on-and-cell function and insulin action in humans. Diabetes. 2013;6 2:2978-2983.
22. Henquin JC, Rahier J. Pancreatic-cell mass in European subjects with type 2 diabetes. Diabetologia. 2011;54:1720-1725.
23. Bosco D, Armanet M, Mo rel P, et al. Unique arrangement of-and-cells in human islets of Langerhans. Diabetes. 2010;59:1202-1210.
24. Kilimnik G, Zhao B, Periwal V, et al. Altered islet composition and disproportionate loss of large islets in patients with type 2 diabetes. PLoS One. 2011;6:e27445.
25. Farhat B, Almelkar A, Ramachandran K, et al. Small human islets comprised of more-cells with higher insulin content than large islets. Islets. 2013;5:87-94.
26. Ritzel RA, Butler AE, Rizza RA, Veldhuis JD, Butler PC. Relationship between-cell mass and fasting blood glucose concentr ation in humans. Diabetes Care. 2006;29:717-718.
27. Saisho Y, Butler AE, Manesso E, et al. Relationship between fractional pancreatic-cell area and fasting plasma glucose concentration in monk eys. Diabetologia. 2010;53:111-114.
28. Meier JJ, Menge BA, Breuer TG, et al. Functional assessment of pancreatic-cell area in humans. Diabetes. 2009;58:1595-1603.
29. Sacks DB. Hemoglobin A1c in diabetes: panacea or pointless Diabetes. 2013;62:41-43.
30. Wolffenbuttel BH, HermanWH,Gross JL, DharmalingamM,Jiang HH, Hardin DS. Ethnic differ ences in glycemic markers in patients with type 2 diabetes. Diabetes Care. 2013;36:2931-2936.
31. Kostromina E, Wang X, Han W. Altered islet morphology but normal islet secretory function in vitro i n a mouse model with microvascular alterations in the pancreas. PLoS One. 2013;8:e71277.
32. Borden P, Houtz J, Leach SD, Kuruvilla R. Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation. Cell Rep. 2013;4:287-301.
33. Gregg BE Moore PC Demozay D et al. Formation of a human-cell population within pancreatic islets is set early in life J Clin Endocrinol Metab. 2012;97(9) 3197-3206.
34. Inoue H, Shintani N, Sakurai Y, et al. PACAP inhibits-cell mass expansion in a mouse model of type II diabetes: persistent suppressive effects on islet density. Front Endocrinol (Lausanne). 2013;4-27.
35. Bringhenti I, Moraes-Teixeira JA, Cunha MR, Ornellas F, Mandarim-de-Lacerda CA, Aguila MB. Maternal obesity during the preconception and early life periods alters pancreatic development in early and adult life in male mouse offspring. PLo S One. 2013;8: e55711.
36. Minami K, Okuno M, Miyawaki K, et al. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci USA. 2005;102:15116-15121.
37. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to-cells. Nature. 2008;455:627-632.
38. Baeyens L, LemperM,Leuckx G, et al. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional-cell mass in diabetic mice. Nat Biotechnol. 2014;32(1):76-83.
39. Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S. Reduced-cell mass and expression of oxidative stressrelatedDNAdamage in the islet of Japanese type II diabetic patients. Diabetologia. 2002;45:85-96.
40. Saisho Y. Pancreas volume with obesity in asians: comparison with whites. Pancreas. 2014;43:657-659.