Altered Islet Morphology but Normal Islet Secretory Function In Vitro in a Mouse Model with Microvascular Alterations in the Pancreas

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Kostromina, Elena ^a   Wang, Xiaorui ^a,c   Han, Weiping ^a,b,c,d  

^a AGENCY FOR SCIENCE   (Singapore)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; STAT3 PROTEIN;

ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GLUCOSE INTOLERANCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INSULIN RELEASE; MICROVASCULATURE; MOUSE; NONHUMAN; ORGANOGENESIS; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PANCREAS SECRETION; SIGNAL TRANSDUCTION;

ANIMALS; FEMALE; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; MICROVESSELS; PANCREAS; STAT3 TRANSCRIPTION FACTOR;

EID: 84880786702     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071277     Document Type: Article

References (41)

1. Ballian N, Brunicardi FC, (2007) Islet vasculature as a regulator of endocrine pancreas function. World journal of surgery 31: 705-714.
2. Gustavsson N, Han W, (2009) Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion. Bioscience reports 29: 245-259.
3. Han W, Chuang KH, Chang YT, Olivo M, Velan SS, et al. (2010) Imaging metabolic syndrome. EMBO molecular medicine 2: 196-210.
4. Bonner-Weir S, Orci L, (1982) New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes 31: 883-889.
5. Brunicardi FC, Stagner J, Bonner-Weir S, Wayland H, Kleinman R, et al. (1996) Microcirculation of the islets of Langerhans. Long Beach Veterans Administration Regional Medical Education Center Symposium. Diabetes 45: 385-392.
6. Konstantinova I, Lammert E, (2004) Microvascular development: learning from pancreatic islets. Bioessays 26: 1069-1075.
7. Habener JF, Kemp DM, Thomas MK, (2005) Minireview: transcriptional regulation in pancreatic development. Endocrinology 146: 1025-1034.
8. Ackermann AM, Gannon M, (2007) Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J Mol Endocrinol 38: 193-206.
9. Darnell JE Jr, (1997) STATs and gene regulation. Science 277: 1630-1635.
10. Takeda K, Akira S, (2001) Multi-functional roles of Stat3 revealed by conditional gene targeting. Arch Immunol Ther Exp (Warsz) 49: 279-283.
11. Levy DE, Lee CK, (2002) What does Stat3 do? J Clin Invest 109: 1143-1148.
12. Akira S, (2000) Roles of STAT3 defined by tissue-specific gene targeting. Oncogene 19: 2607-2611.
13. Niu G, Wright KL, Huang M, Song L, Haura E, et al. (2002) Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21: 2000-2008.
14. Wei D, Le X, Zheng L, Wang L, Frey JA, et al. (2003) Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22: 319-329.
15. Kostromina E, Gustavsson N, Wang X, Lim CY, Radda GK, et al. (2010) Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas. Endocrinology 151: 2050-2059.
16. Lammert E, Gu G, McLaughlin M, Brown D, Brekken R, et al. (2003) Role of VEGF-A in vascularization of pancreatic islets. Curr Biol 13: 1070-1074.
17. Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, et al. (2006) Pancreatic islet production of vascular endothelial growth factor - a is essential for islet vascularization, revascularization, and function. Diabetes 55: 2974-2985.
18. Nikolova G, Lammert E, (2003) Interdependent development of blood vessels and organs. Cell Tissue Res 314: 33-42.
19. Iwashita N, Uchida T, Choi JB, Azuma K, Ogihara T, et al. (2007) Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice. Diabetologia 50: 380-389.
20. Watada H, (2010) Role of VEGF-A in pancreatic beta cells. Endocr J 57: 185-191.
21. Lammert E, Cleaver O, Melton D, (2001) Induction of pancreatic differentiation by signals from blood vessels. Science 294: 564-567.
22. Cleaver O (2004) Blood Vessel Signals During Development and Beyond. In: Gerald PS, editor. Current Topics in Developmental Biology: Academic Press. 1-36.
23. Gustavsson N, Wei SH, Hoang DN, Lao Y, Zhang Q, et al. (2009) Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+-induced glucagon exocytosis in pancreas. The Journal of physiology 587: 1169-1178.
24. Huang HH, Farmer K, Windscheffel J, Yost K, Power M, et al. (2011) Exercise increases insulin content and basal secretion in pancreatic islets in type 1 diabetic mice. Exp Diabetes Res 2011: 481427.
25. Gustavsson N, Lao Y, Maximov A, Chuang JC, Kostromina E, et al. (2008) Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc Natl Acad Sci U S A 105: 3992-3997.
26. Dawson CM, Atwater I, Rojas E, (1982) Potassium-induced insulin release and voltage noise measurements in single mouse islets of Langerhans. J Membr Biol 64: 33-43.
27. Li Z, Karlsson FA, Sandler S, (2000) Islet loss and alpha cell expansion in type 1 diabetes induced by multiple low-dose streptozotocin administration in mice. J Endocrinol 165: 93-99.
28. Ahlgren U, Kostromina E (2011) Imaging the Pancreatic Beta Cell. In: Wagner D, editor. Type 1 Diabetes - Pathogenesis, Genetics and Immunotherapy: InTech. 269-292.
29. Bonner-Weir S (2005) Islets of Langerhans: morphology and postnatal growth. In: Joslin EP KC, et al. editor. Joslin's Diabetes Mellitus: Philadelphia: Lippincott Williams & Willkins. 41-52.
30. Trimble ER, Halban PA, Wollheim CB, Renold AE, (1982) Functional differences between rat islets of ventral and dorsal pancreatic origin. J Clin Invest 69: 405-413.
31. Ellenbroek JH, Tons HA, de Graaf N, Loomans CJ, Engelse MA, et al. (2013) Topologically heterogeneous beta cell adaptation in response to high-fat diet in mice. PLoS One 8: e56922.
32. Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, et al. (2006) The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci U S A 103: 2334-2339.
33. Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, et al. (2004) Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem Biophys Res Commun 319: 1159-1170.
34. Marks V, Samols E, Stagner J (1992) Intra-islet interactions. In: Flatt PR, editor. Nutrient Regulation of Insulin Secretion. London, UK: Portland Press. 41-57.
35. Meda P, (2013) Protein-Mediated Interactions of Pancreatic Islet Cells. Scientifica 2013: 22.
36. Ballian N, Brunicardi FC, (2007) Islet vasculature as a regulator of endocrine pancreas function. World J Surg 31: 705-714.
37. Nyman LR, Wells KS, Head WS, McCaughey M, Ford E, et al. (2008) Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets. J Clin Invest 118: 3790-3797.
38. Colella RM, Bonner-Weir S, Braunstein LP, Schwalke M, Weir GC, (1985) Pancreatic islets of variable size - insulin secretion and glucose utilization. Life Sci 37: 1059-1065.
39. Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, et al. (2010) Conditional gene targeting in mouse pancreatic Beta-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 59: 3090-3098.
40. Schwartz MW, Guyenet SJ, Cirulli V, (2010) The hypothalamus and beta-cell connection in the gene-targeting era. Diabetes 59: 2991-2993.
41. Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, et al. (2003) STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421: 856-859.