Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α-And β-Cell function and insulin action in humans

Diabetes

Volumn 62, Issue 8, 2013, Pages 2978-2983

  Jonsson, Anna ^a,b   Ladenvall, Claes ^a   Ahluwalia, Tarunveer Singh ^a,b   Kravic, Jasmina ^a   Krus, Ulrika ^a   Taneera, Jalal ^a   Isomaa, Bo ^c,d   Tuomi, Tiinamaija ^c,e   Renström, Erik ^a   Groop, Leif ^a,f   Lyssenko, Valeriya ^a,g  

^a LUND UNIVERSITY DIABETES CENTRE   (Sweden)

^b Capital Region   (Denmark)

^c FOLKHÄLSAN RESEARCH CENTER   (Finland)

^d Department of Social Services and Health Care ^*  (Finland)

^e HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^f UNIVERSITY OF HELSINKI   (Finland)

^g STENO DIABETES CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOCHROME 2; GLUCAGON; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; NOTCH2 RECEPTOR; PROTEIN; PROTEIN BCL 11A PROTEIN; SOMATOMEDIN; SOMATOMEDIN 2 BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 2; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL;

ALLELE; ARTICLE; DIET RESTRICTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC TRAIT; GENETIC VARIABILITY; GLUCAGON BLOOD LEVEL; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; INSULIN SENSITIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PARTICIPATORY RESEARCH; PLEIOTROPY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ADULT; FINLAND; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; METABOLISM;

ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FINLAND; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GLUCAGON-SECRETING CELLS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84891722250     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1627     Document Type: Article

References (16)

1. Voight BF, Scott LJ, Steinthorsdottir V, et al.; MAGIC investigators; GIANT Consortium. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 2010;42:579-589
2. Dupuis J, Langenberg C, Prokopenko I, et al.; DIAGRAM Consortium; GIANT Consortium; Global BPgen Consortium; Anders Hamsten on behalf of Procardis Consortium; MAGIC investigators. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010;42:105-116
3. Isomaa B, Forsén B, Lahti K, et al. A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study. Diabetologia 2010;53: 1709-1713
4. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999;22:1462-1470
5. Hanson RL, Pratley RE, Bogardus C, et al. Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am J Epidemiol 2000;151:190-198
6. Jonsson A, Isomaa B, Tuomi T, et al. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes 2009;58:2409-2413
7. PLINK. Whole genome association analysis toolset [Internet], 2009. Available from http://pngu.mgh.harvard.edu/~purcell/plink/. Accessed 10 October 2009
8. Purcell S, Neale B, Todd-Brown K, et al. PLINK: A tool set for wholegenome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-575
9. Alibegovic AC, Sonne MP, Højbjerre L, et al. The T-Allele of TCF7L2 rs7903146 associates with a reduced compensation of insulin secretion for insulin resistance induced by 9 days of bed rest. Diabetes 2010;59:836-843
10. Grarup N, Sparsø T, Hansen T. Physiologic characterization of type 2 diabetes-related loci. Curr Diab Rep 2010;10:485-497
11. Pilgaard K, Jensen CB, Schou JH, et al. The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men. Diabetologia 2009;52:1298-1307
12. Lyssenko V, Jonsson A, Almgren P, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 2008;359: 2220-2232
13. Lyssenko V, Lupi R, Marchetti P, et al. Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 2007;117:2155-2163
14. Boj SF, van Es JH, Huch M, et al. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell 2012;151:1595-1607
15. Norton L, Fourcaudot M, Abdul-Ghani MA, et al. Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism. Diabetologia 2011;54:3132-3142
16. Simonis-Bik AM, Nijpels G, van Haeften TW, et al. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. Diabetes 2010;59:293-301