The liver in sepsis: Patterns of response and injury

Current Opinion in Critical Care

Volumn 19, Issue 2, 2013, Pages 123-127

  Bauer, Michael ^a   Press, Adrian T ^a   Trauner, Michael ^b  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

acute phase; biotransformation; cholestasis; stress response; transcriptomics

Indexed keywords

ACUTE PHASE PROTEIN;

BIOTRANSFORMATION; GENE EXPRESSION; HUMAN; LIVER CELL; LIVER DISEASE; LIVER DYSFUNCTION; LIVER INJURY; NEUTROPHIL; REVIEW; SENSITIVITY AND SPECIFICITY; SEPSIS;

ACUTE-PHASE PROTEINS; CRITICAL CARE; END STAGE LIVER DISEASE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTENSIVE CARE UNITS; INTERLEUKIN-6; LIVER; LIVER DISEASES; LIVER FUNCTION TESTS; MALE; PROGNOSIS; SEPSIS; SIGNAL TRANSDUCTION;

EID: 84874763228     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0b013e32835eba6d     Document Type: Review

References (36)

1. Whitehead MW, Hainsworth I, Kingham JG. The causes of obvious jaundice in South West Wales: perceptions versus reality. Gut 2001; 48:409-413. (Pubitemid 32269572)
2. Kramer L, Jordan B, Druml W, et al. Incidence and prognosis of early hepatic dysfunction in critically ill patients: a prospective multicenter study. Crit Care Med 2007; 35:1099-1104. (Pubitemid 46598961)
3. Kobashi H, Toshimori J, Yamamoto K, et al. Sepsis-associated liver injury: incidence, classification and the clinical significance. Hepatol Res 2012 [Epub ahead of print].
4. Taylor NJ, Nishtala A, Manakkat Vijay GK, et al. Circulating neutrophil dysfunction in acute liver failure. Hepatology 2012 [Epub ahead of print].
5. van Hoek AJ, Andrews N, Waight PA, et al. The effect of underlying clinical conditions on the risk of developing invasive pneumococcal disease in England. J Infect 2012; 65:17-24.
6. Marshall JC. New translational research provides insights into liver dysfunction in sepsis. PLoS Med 2012; 9:e1001341.
7. Watanabe K, Ishima Y, Akaike T, et al. S-nitrosated alpha-1-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis. FASEB J 2013; 27:391-398.
8. Tzepi IM, Giamarellos-Bourboulis EJ, Carrer DP, et al. Angiopoietin-2 enhances survival in experimental sepsis induced by multidrug-resistant Pseudomonas aeruginosa. J Pharmacol Exp Ther 2012; 343:278-287.
9. Vodovotz Y, Prelich J, Lagoa C, et al. Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: in vitro, in vivo, and in silico studies. Mol Med 2012; 18:1421-1429.
10. Giebeler A, Brandenburg LO, Kaldenach M, et al. Lack of hepatic c-Met and gp130 expression is associated with an impaired antibacterial response and higher lethality after bile duct ligation. Lab Invest 2012; 92:1726-1737.
11. Cobb JP, Laramie JM, Stormo GD, et al. Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays. Crit Care Med 2002; 30:2711-2721. (Pubitemid 36870574)
12. Warg LA, Oakes JL, Burton R, et al. The role of the E2F1 transcription factor in the innate immune response to systemic LPS. Am J Physiol Lung Cell Mol Physiol 2012; 303:L391-L400.
13. Mattick JS, Yang Q, Orman MA, et al. Long-term gene expression profile dynamics following cecal ligation and puncture in the rat. J Surg Res 2012; 178:431-442.
14. Weber M, Lambeck S, Ding N, et al. Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB J 2012; 26:2424-2436.
15. Rudiger A, Dyson A, Felsmann K, et al. Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis. Clin Sci (Lond) 2013; 124:391-401.
16. Recknagel P, Gonnert FA, Westermann M, et al. Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis. PLoS Med 2012; 9:e1001338.
17. Geier A, Fickert P, Trauner M. Mechanisms of disease: mechanisms and clinical implications of cholestasis in sepsis. Nat Clin Pract Gastroenterol Hepatol 2006; 3:574-585. (Pubitemid 44489590)
18. Singer G, Stokes KY, Neil Granger D. Reactive oxygen and nitrogen species in sepsis-induced hepatic microvascular dysfunction. Inflamm Res 2013; 62:155-164.
19. Nweze IC, Smith JW, Zhang B, et al. 17beta-Estradiol attenuates cytokineinduced nitric oxide production in rat hepatocyte. J Trauma Acute Care Surg 2012; 73:408-412.
20. Oral A, Unal D, Halici Z, et al. Bilateral ovariectomy in young rats: what happens in their livers during cecal ligation and puncture induced sepsis? J Pediatr Adolesc Gynecol 2012; 25:371-379.
21. Kawasaki T, Chaudry IH. The effects of estrogen on various organs: therapeutic approach for sepsis, trauma, and reperfusion injury. Part 2: liver, intestine, spleen, and kidney. J Anesth 2012; 26:892-899.
22. Gais P, Reim D, Jusek G, et al. Cutting edge: divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis. J Immunol 2012; 188:5833-5837.
23. Xie K, Fu W, Xing W, et al. Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. Shock 2012; 38:656-663.
24. Norris EJ, Larion S, Culberson CR, et al. Hydrogen sulfide differentially affects the hepatic vasculature in response to phenylephrine and endothelin 1 during endotoxemia. Shock 2013; 39:168-175.
25. Laschke MW, Menger MD, m Wang Y, et al. Sepsis-associated cholestasis is critically dependent on P-selectin-dependent leukocyte recruitment in mice. Am J Physiol Gastrointest Liver Physiol 2007; 292:G1396-G1402. (Pubitemid 47084669)
26. Geier A, Dietrich CG, Voigt S, et al. Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis. Hepatology 2003; 38:345-354. (Pubitemid 36919855)
27. Trauner M, Fickert P, Stauber RE. Inflammation-induced cholestasis. J Gastroenterol Hepatol 1999; 14:946-959. (Pubitemid 29487289)
28. Oude Elferink RP, Jansen PL. The role of the canalicular multispecific organic anion transporter in the disposal of endo-and xenobiotics. Pharmacol Ther 1994; 64:77-97. (Pubitemid 24324175)
29. Aydin S, Tokaç M, Taner G. Antioxidant and antigenotoxic effects of lycopene in obstructive jaundice. J Surg Res 2012.
30. Allameh A, Razavi-Azarkhiavi K, Mohsenifar A, et al. Effect of acute ethanol treatment on biochemical and histopathological factors in rat liver in an experimental sepsis model. Pathol Res Pract 2012; 208:331-337.
31. Recknagel P, Gonnert FA, Halilbasic E, et al. Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats. Liver Int 2013; 33:283-293.
32. McDonald B, Urrutia R, Yipp BG, et al. Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. Cell Host Microbe 2012; 12:324-333.
33. Cullen DJ, Sweitzer BJ, Bates DW, et al. Preventable adverse drug events in hospitalized patients: a comparative study of intensive care and general care units. Crit Care Med 1997; 25:1289-1297. (Pubitemid 27347291)
34. La Mura V, Pasaŕn M, Meireles CZ, et al. Effects of simvastatin administration on rats with LPS induced liver microvascular dysfunction. Hepatology 2012 [Epub ahead of print].
35. Kruger PS, Freir NM, Venkatesh B, et al. A preliminary study of atorvastatin plasma concentrations in critically ill patients with sepsis. Intensive Care Med 2009; 35:717-721.
36. Vanwijngaerden YM, Wauters J, Langouche L, et al. Critical illness evokes elevated circulating bile acids related to altered hepatic transporter and nuclear receptor expression. Hepatology 2011; 54:1741-1752.