Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo

Atherosclerosis

Volumn 219, Issue 1, 2011, Pages 57-64

  Kim, Young Min ^a   Kim, Min Young ^a   Kim, Hye Jung ^a   Roh, Gu Seob ^a   Ko, Gyung Hyuck ^a   Seo, Han Geuk ^a   Lee, Jae Heun ^a   Chang, Ki Churl ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Adhesion molecules; Compound C; Endothelial cells; Inflammation; NF B

Indexed keywords

6 [4 (2 PIPERIDIN 1 YLETHOXY)PHENYL] 3 PYRIDIN 4 YLPYRAZOLO[1,5 ALPHA]PYRIMIDINE; ADENYLATE KINASE; BETA ACTIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE B; SMALL INTERFERING RNA; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL NUCLEUS; CONTROLLED STUDY; DRUG TARGETING; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RNA TRANSLATION; THORACIC AORTA;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PYRAZOLES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 80054982173     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.06.043     Document Type: Article

References (28)

1. Collins T., Cybulsky M.I. NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?. J Clin Invest 2001, 107:255-264.
2. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
3. Munro J.M., Cotran R.S. Biology of disease: the pathogenesis of atherosclerosis: atherogenesis and inflammation. Lab Invest 1998, 58:249-261.
4. Collins T., Read M.A., Neish A.S., Whitley M.Z., Thanos D., Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB J 1995, 9:899-909.
5. Neish A.S., Williams A.J., Palmer H.J., Whitley M.Z., Collins T. Functional analysis of human vascular cell adhesion molecule 1 promoter. J Exp Med 1992, 176:1583-1593.
6. Shu H.B., Agranoff A.B., Nabel E.G., et al. Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-κB subunits in endothelial and epithelial cells. Mol Cell Biol 1993, 13:6283-6289.
7. Springer T.A. Traffic signals for leukocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994, 76:301-314.
8. Dong Y., Zhang M., Wang S., et al. Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo. Diabetes 2010, 59:1386-1396.
9. Zhang W., Wang J., Wang H., et al. Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. Arterioscler Thromb Vasc Biol 2010, 30:1000-1006.
10. Prasad R., Giri S., Nath N., Singh I., Singh A.K. 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction. J Neurosci Res 2006, 84:614-625.
11. Gaskin F.S., Kamada K., Yusof M., Korthuis R.J. 5'-AMP-activated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions. Am J Physiol Heart Circ Physiol 2007, 292:H326-H332.
12. Zhou G., Myers R., Li Y., et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001, 108:1167-1174.
13. Nam M., Lee W.H., Bae E.J., Kim S.G. Compound C inhibits clonal expansion of preadipocytes by increasing p21 level irrespectively of AMPK inhibition. Arch Biochem Biophys 2008, 479:74-81.
14. Jang J.H., Lee T.J., Yang E.S., et al. Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1. Exp Cell Res 2010, 316:2194-2203.
15. Emerling B.M., Viollet B., Tormos K.V., Chandel N.S. Compound C inhibits hypoxic activation of HIF-1 independent of AMPK. FEBS Lett 2007, 581:5727-5731.
16. Vucicevic L., Misirkic M., Janjetovic K., et al. induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy 2011, 7:40-50.
17. Chang C.K., Albarillo M.V., Schumer W. Therapeutic effect of dimethyl sulfoxide on ICAM-1 gene expression and activation of NF-kappaB and AP-1 in septic rats. J Surg Res 2001, 95(February (2)):181-187.
18. Lee Y.R., Shim H.J., Yu H.N., et al. Dimethylsulfoxide induces upregulation of tumor suppressor protein PTEN through nuclear factor-kappaB activation in HL-60 cells. Leuk Res 2005, 29(April (4)):401-405.
19. Liang C., Xue Z., Cang J., Wang H., Li P. Dimethyl sulfoxide induces heme oxygenase-1 expression via JNKs and Nrf2 pathways in human umbilical vein endothelial cells. Mol Cell Biochem 2011, [Epub ahead of print].
20. Liu J., Yoshikawa H., Nakajima Y., Tasaka K. Involvement of mitochondrial permeability transition and caspase-9 activation in dimethyl sulfoxide-induced apoptosis of EL-4 lymphoma cells. Int Immunopharmacol 2001, 1:63-74.
21. Gurtovenko A.A., Anwar J. Modulating the structure and properties of cell membranes: the molecular mechanism of action of dimethyl sulfoxide. J Phys Chem B 2007, 111:10453-10460.
22. Laskar A., Yuan X.M., Li W. Dimethyl sulfoxide prevents 7beta-hydroxycholesterol-induced apoptosis by preserving lysosomes and mitochondria. J Cardiovasc Pharmacol 2010, 56:263-267.
23. Tsoyi K., Jang H.J., Nizamutdinova I.T., et al. PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells. Atherosclerosis 2010, 213:115-121.
24. Moon L., Ha Y.M., Jang H.J., et al. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae Rhizome inhibit TNF-α-induced VCAM-1 expression in human endothelial cells: involvement of PPAR-γ upregulation and PI3K, ERK1/2, and PKC signal pathways. J Ethnopharmacol 2011, 133:336-344.
25. Nizamutdinova I.T., Jeong J.J., Xu G.H., et al. Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliate (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells. Int Immunopharmacol 2008, 8:670-678.
26. Chance B.H., Sies H., Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979, 59:527-605.
27. Magder S., Neculcea J., Neculcea V., Sladek R. Lipopolysaccharide and TNF-alpha produce very similar changes in gene expression in human endothelial cells. J Vasc Res 2006, 43:447-461.
28. Tsoyi K., Jang H.J., Nizamutdinova I.T., et al. Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice. Br J Pharmacol 2011, 162:1498-1508.