Oocyte-derived BMP15 but not GDF9 down-regulates connexin43 expression and decreases gap junction intercellular communication activity inimmortalized human granulosa cells

Molecular Human Reproduction

Volumn 20, Issue 5, 2014, Pages 373-383

  Chang, Hsun Ming ^a   Cheng, Jung Chien ^a   Taylor, Elizabeth ^a   Leung, Peter C K ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

BMP15; Connexin43; GDF9; Human granulosa cell; Smad

Indexed keywords

BONE MORPHOGENETIC PROTEIN 15; CONNEXIN 43; GROWTH DIFFERENTIATION FACTOR 9; SMAD1 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; (6-(4-(2-PIPERIDIN-1-YLETHOXY)PHENYL))-3-PYRIDIN-4-YLPYRAZOLO(1,5-A)PYRIMIDINE; BMP15 PROTEIN, HUMAN; GDF9 PROTEIN, HUMAN; GJA1 PROTEIN, HUMAN; MESSENGER RNA; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; RECEPTOR REGULATED SMAD PROTEIN;

ARTICLE; CELL COMMUNICATION; DOWN REGULATION; FERTILIZATION IN VITRO; GAP JUNCTION; GRANULOSA CELL; HUMAN; HUMAN CELL; IMMORTALIZED CELL LINE; INTRACELLULAR SIGNALING; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; CELL LINE; DRUG EFFECTS; FEMALE; GENETICS; METABOLISM; PARACRINE SIGNALING; PHOSPHORYLATION; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TIME;

BONE MORPHOGENETIC PROTEIN 15; CELL LINE; CONNEXIN 43; DOWN-REGULATION; FEMALE; GAP JUNCTIONS; GRANULOSA CELLS; GROWTH DIFFERENTIATION FACTOR 9; HUMANS; OOCYTES; PARACRINE COMMUNICATION; PHOSPHORYLATION; PRIMARY CELL CULTURE; PYRAZOLES; PYRIMIDINES; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD PROTEINS, RECEPTOR-REGULATED; TIME FACTORS;

EID: 84899843876     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gau001     Document Type: Article

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