Abundant non-canonical dUTP found in primary human macrophages drives its frequent incorporation by HIV-1 reverse transcriptase

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 25047-25055

  Kennedy, Edward M ^a   Daddacha, Waaqo ^a   Slater, Rebecca ^a   Gavegnano, Christina ^b   Fromentin, Emilie ^b   Schinazi, Raymond F ^b   Kim, Baek ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL SIMULATIONS; DNA SYNTHESISS; HIV-1 REVERSE TRANSCRIPTASE; HUMAN MACROPHAGES; LC-MS/MS; NUCLEOTIDE POOLS; PHYSIOLOGICAL CONDITION; PRE-STEADY STATE; REVERSE TRANSCRIPTION; SIMIAN IMMUNODEFICIENCY VIRUS; STEADY-STATE KINETICS; T CELLS; TARGET CELLS;

LAKES; MACROPHAGES; NUCLEOTIDES; TRANSCRIPTION; VIRUSES;

DISEASES;

2',3' DIDEOXYURIDINE; DEOXYURIDINE TRIPHOSPHATE; NUCLEOSIDE TRIPHOSPHATE; RNA DIRECTED DNA POLYMERASE; THYMIDINE TRIPHOSPHATE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE; VIRUS DNA;

ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MACROPHAGE; PRIORITY JOURNAL; PROVIRUS; REVERSE TRANSCRIPTION; SIMIAN IMMUNODEFICIENCY VIRUS; SIMULATION; STEADY STATE; T LYMPHOCYTE;

CELLS, CULTURED; DNA, VIRAL; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; KINETICS; MACROPHAGES; PROVIRUSES; REVERSE TRANSCRIPTION; SIMIAN IMMUNODEFICIENCY VIRUS; URIDINE TRIPHOSPHATE;

HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 79960124315     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.234047     Document Type: Article

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