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Volumn 11, Issue 5, 2014, Pages 1459-1470

PEGylated, NH2-terminated PAMAM dendrimers: A microscopic view from atomistic computer simulations

Author keywords

atomistic simulations; dendrimers; drug delivery; molecular dynamics; PAMAM; PEGylation

Indexed keywords

AMINE; DENDRIMER; LIGAND; MACROGOL; NANOCARRIER; POLYAMIDOAMINE; MACROGOL DERIVATIVE; PAMAM STARBURST;

EID: 84899798868     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400630z     Document Type: Article
Times cited : (23)

References (82)
  • 1
    • 84861956547 scopus 로고    scopus 로고
    • Dendrimer-based bionanomaterials produced by surface modification, assembly and hybrid formation
    • Kono, K. Dendrimer-based bionanomaterials produced by surface modification, assembly and hybrid formation Polym. J. 2012, 44 (6) 531-540
    • (2012) Polym. J. , vol.44 , Issue.6 , pp. 531-540
    • Kono, K.1
  • 2
    • 81355122670 scopus 로고    scopus 로고
    • PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography
    • Peng, C. PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography Biomaterials 2012, 33 (4) 1107-1119
    • (2012) Biomaterials , vol.33 , Issue.4 , pp. 1107-1119
    • Peng, C.1
  • 3
    • 84859925443 scopus 로고    scopus 로고
    • Potential use of folate-polyethylene glycol (PEG)-appended dendrimer (G3) conjugate with α-cyclodextrin as DNA carriers to tumor cells
    • Arima, H. Potential use of folate-polyethylene glycol (PEG)-appended dendrimer (G3) conjugate with α-cyclodextrin as DNA carriers to tumor cells Cancer Gene Ther. 2012, 19 (5) 358-366
    • (2012) Cancer Gene Ther. , vol.19 , Issue.5 , pp. 358-366
    • Arima, H.1
  • 4
    • 28744443398 scopus 로고    scopus 로고
    • Dendrimers in biomedical applications - Reflections on the field
    • Svenson, S. Dendrimers in biomedical applications - reflections on the field Adv. Drug Delivery Rev. 2005, 54, 2106-2129
    • (2005) Adv. Drug Delivery Rev. , vol.54 , pp. 2106-2129
    • Svenson, S.1
  • 5
    • 84859807079 scopus 로고    scopus 로고
    • The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry
    • Huang, B. The facile synthesis of multifunctional PAMAM dendrimer conjugates through copper-free click chemistry Bioorg. Med. Chem. Lett. 2012, 22 (9) 3152-3156
    • (2012) Bioorg. Med. Chem. Lett. , vol.22 , Issue.9 , pp. 3152-3156
    • Huang, B.1
  • 6
    • 84865955791 scopus 로고    scopus 로고
    • Folate-PEG-appended dendrimer conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA delivery carrier
    • Arima, H. Folate-PEG-appended dendrimer conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA delivery carrier Mol. Pharmaceutics 2012, 9 (9) 2591-2604
    • (2012) Mol. Pharmaceutics , vol.9 , Issue.9 , pp. 2591-2604
    • Arima, H.1
  • 7
    • 84862022053 scopus 로고    scopus 로고
    • Efficient in vitro siRNA delivery and intramuscular gene silencing using PEG-modified PAMAM dendrimers
    • Tang, Y. Efficient in vitro siRNA delivery and intramuscular gene silencing using PEG-modified PAMAM dendrimers Mol. Pharmaceutics 2012, 9 (6) 1812-1821
    • (2012) Mol. Pharmaceutics , vol.9 , Issue.6 , pp. 1812-1821
    • Tang, Y.1
  • 8
    • 84884476065 scopus 로고    scopus 로고
    • The influence of PAMAM dendrimers surface groups on their interaction with porcine pepsin
    • Ciolkowski, M. The influence of PAMAM dendrimers surface groups on their interaction with porcine pepsin Biochim. Biophys. Acta, Proteins Proteomics 2013, 1834, 1982-1987
    • (2013) Biochim. Biophys. Acta, Proteins Proteomics , vol.1834 , pp. 1982-1987
    • Ciolkowski, M.1
  • 9
    • 84878289500 scopus 로고    scopus 로고
    • Charge affects the oral toxicity of poly(amido amine) dendrimers
    • Thiagarajan, G. Charge affects the oral toxicity of poly(amido amine) dendrimers Eur. J. Pharm. Biopharm. 2013, 84, 330-334
    • (2013) Eur. J. Pharm. Biopharm. , vol.84 , pp. 330-334
    • Thiagarajan, G.1
  • 10
    • 84876707812 scopus 로고    scopus 로고
    • Modified PAMAM dendrimer with 4-carbomethoxypyrrolidone surface groups reveals negligible toxicity against three rodent cell-lines
    • Janaszewska, A. Modified PAMAM dendrimer with 4-carbomethoxypyrrolidone surface groups reveals negligible toxicity against three rodent cell-lines Nanomedicine 2013, 9, 461-464
    • (2013) Nanomedicine , vol.9 , pp. 461-464
    • Janaszewska, A.1
  • 11
    • 84862001474 scopus 로고    scopus 로고
    • Cationic PAMAM dendrimers disrupt key platelet functions
    • Jones, C. F. Cationic PAMAM dendrimers disrupt key platelet functions Mol. Pharmaceutics 2012, 9 (6) 1599-1611
    • (2012) Mol. Pharmaceutics , vol.9 , Issue.6 , pp. 1599-1611
    • Jones, C.F.1
  • 12
    • 84865957139 scopus 로고    scopus 로고
    • PAMAM dendrimer-baculovirus nanocomplex for microencapsulated adipose stem cell-gene therapy: In vitro and in vivo functional assessment
    • Paul, A. PAMAM dendrimer-baculovirus nanocomplex for microencapsulated adipose stem cell-gene therapy: in vitro and in vivo functional assessment Mol. Pharmaceutics 2012, 9 (9) 2479-2488
    • (2012) Mol. Pharmaceutics , vol.9 , Issue.9 , pp. 2479-2488
    • Paul, A.1
  • 13
    • 0035009885 scopus 로고    scopus 로고
    • SAXS and SANS studies of polymer colloids
    • Ballauff, M. SAXS and SANS studies of polymer colloids Curr. Opin. Colloid Interface Sci. 2001, 6 (2) 132-139
    • (2001) Curr. Opin. Colloid Interface Sci. , vol.6 , Issue.2 , pp. 132-139
    • Ballauff, M.1
  • 14
    • 67749118138 scopus 로고    scopus 로고
    • PAMAM dendrimers undergo pH responsive conformational changes without swelling
    • Liu, Y. PAMAM dendrimers undergo pH responsive conformational changes without swelling J. Am. Chem. Soc. 2009, 131 (8) 2798-2799
    • (2009) J. Am. Chem. Soc. , vol.131 , Issue.8 , pp. 2798-2799
    • Liu, Y.1
  • 15
    • 57449097406 scopus 로고    scopus 로고
    • Structural investigation of PAMAM dendrimers in aqueous solutions using small-angle neutron scattering: Effect of generation
    • Porcar, L. Structural investigation of PAMAM dendrimers in aqueous solutions using small-angle neutron scattering: effect of generation J. Phys. Chem. B 2008, 112 (47) 14772-14778
    • (2008) J. Phys. Chem. B , vol.112 , Issue.47 , pp. 14772-14778
    • Porcar, L.1
  • 16
    • 0033204293 scopus 로고    scopus 로고
    • Effect of solvent quality on the molecular dimensions of PAMAM dendrimers
    • Topp, A. Effect of solvent quality on the molecular dimensions of PAMAM dendrimers Macromolecules 1999, 32 (21) 7232-7237
    • (1999) Macromolecules , vol.32 , Issue.21 , pp. 7232-7237
    • Topp, A.1
  • 17
    • 84899891568 scopus 로고    scopus 로고
    • SANS study of labeled PAMAM dendrimer
    • American Chemical Society: Washington, DC
    • Amis, E.; SANS study of labeled PAMAM dendrimer. Abstracts of Papers; American Chemical Society: Washington, DC, 1997.
    • (1997) Abstracts of Papers
    • Amis, E.1
  • 18
    • 0031342747 scopus 로고    scopus 로고
    • A SAXS study of the internal structure of dendritic polymer systems
    • Prosa, T. J. A SAXS study of the internal structure of dendritic polymer systems J. Polym. Sci., Part B: Polym. Phys. 1997, 35 (17) 2913-2924
    • (1997) J. Polym. Sci., Part B: Polym. Phys. , vol.35 , Issue.17 , pp. 2913-2924
    • Prosa, T.J.1
  • 19
    • 28744458766 scopus 로고    scopus 로고
    • Characterization of dendrimers
    • Caminade, A.-M. Characterization of dendrimers Adv. Drug Delivery Rev. 2005, 57 (15) 2130-2146
    • (2005) Adv. Drug Delivery Rev. , vol.57 , Issue.15 , pp. 2130-2146
    • Caminade, A.-M.1
  • 20
    • 0033136536 scopus 로고    scopus 로고
    • A small angle scattering study of dendrimer-copper sulfide nanocomposites
    • Beck Tan, N. A small angle scattering study of dendrimer-copper sulfide nanocomposites Polymer 1999, 40 (10) 2537-2545
    • (1999) Polymer , vol.40 , Issue.10 , pp. 2537-2545
    • Beck Tan, N.1
  • 21
    • 0032590552 scopus 로고    scopus 로고
    • Structural analysis of spherical water-soluble dendrimer by SANS
    • Funayama, K. Structural analysis of spherical water-soluble dendrimer by SANS J. Phys. Chem. Solids 1999, 60 (8) 1355-1357
    • (1999) J. Phys. Chem. Solids , vol.60 , Issue.8 , pp. 1355-1357
    • Funayama, K.1
  • 22
    • 16244420781 scopus 로고    scopus 로고
    • Molecular dynamics simulation of PAMAM dendrimer in aqueous solution
    • Han, M. Molecular dynamics simulation of PAMAM dendrimer in aqueous solution Polymer 2005, 46 (10) 3481-3488
    • (2005) Polymer , vol.46 , Issue.10 , pp. 3481-3488
    • Han, M.1
  • 23
    • 79960707221 scopus 로고    scopus 로고
    • The effect of pH on PAMAM dendrimer-siRNA complexation - Endosomal considerations as determined by molecular dynamics simulation
    • Ouyang, D. The effect of pH on PAMAM dendrimer-siRNA complexation - endosomal considerations as determined by molecular dynamics simulation Biophys. Chem. 2011, 158 (2) 126-133
    • (2011) Biophys. Chem. , vol.158 , Issue.2 , pp. 126-133
    • Ouyang, D.1
  • 24
    • 4344634395 scopus 로고    scopus 로고
    • Structure of PAMAM dendrimers: Generations 1 through 11
    • Maiti, P. K. Structure of PAMAM dendrimers: generations 1 through 11 Macromolecules 2004, 37 (16) 6236-6254
    • (2004) Macromolecules , vol.37 , Issue.16 , pp. 6236-6254
    • Maiti, P.K.1
  • 25
    • 1642485164 scopus 로고    scopus 로고
    • Coarse grained model for semiquantitative lipid simulations
    • Marrink, S. J. Coarse grained model for semiquantitative lipid simulations J. Phys. Chem. B 2004, 108 (2) 750-760
    • (2004) J. Phys. Chem. B , vol.108 , Issue.2 , pp. 750-760
    • Marrink, S.J.1
  • 26
    • 33749607009 scopus 로고    scopus 로고
    • Molecular dynamics simulations of PAMAM dendrimer-induced pore formation in DPPC bilayers with a coarse-grained model
    • Lee, H. Molecular dynamics simulations of PAMAM dendrimer-induced pore formation in DPPC bilayers with a coarse-grained model J. Phys. Chem. B 2006, 110 (37) 18204-18211
    • (2006) J. Phys. Chem. B , vol.110 , Issue.37 , pp. 18204-18211
    • Lee, H.1
  • 27
    • 34547474332 scopus 로고    scopus 로고
    • The MARTINI force field: Coarse grained model for biomolecular simulations
    • Marrink, S. J. The MARTINI force field: coarse grained model for biomolecular simulations J. Phys. Chem. B 2007, 111 (27) 7812-7824
    • (2007) J. Phys. Chem. B , vol.111 , Issue.27 , pp. 7812-7824
    • Marrink, S.J.1
  • 28
    • 49449113010 scopus 로고    scopus 로고
    • The MARTINI coarse-grained force field: Extension to proteins
    • Monticelli, L. The MARTINI coarse-grained force field: extension to proteins J. Chem. Theory Comput. 2008, 4 (5) 819-834
    • (2008) J. Chem. Theory Comput. , vol.4 , Issue.5 , pp. 819-834
    • Monticelli, L.1
  • 29
    • 54249159300 scopus 로고    scopus 로고
    • Lipid bilayer curvature and pore formation induced by charged linear polymers and dendrimers: The effect of molecular shape
    • Lee, H. Lipid bilayer curvature and pore formation induced by charged linear polymers and dendrimers: the effect of molecular shape J. Phys. Chem. B 2008, 112 (39) 12279-12285
    • (2008) J. Phys. Chem. B , vol.112 , Issue.39 , pp. 12279-12285
    • Lee, H.1
  • 30
    • 79953714899 scopus 로고    scopus 로고
    • Membrane pore formation induced by acetylated and polyethylene glycol-conjugated polyamidoamine dendrimers
    • Lee, H. Membrane pore formation induced by acetylated and polyethylene glycol-conjugated polyamidoamine dendrimers J. Phys. Chem. C 2011, 115 (13) 5316-5322
    • (2011) J. Phys. Chem. C , vol.115 , Issue.13 , pp. 5316-5322
    • Lee, H.1
  • 31
    • 13444266498 scopus 로고    scopus 로고
    • Effect of solvent and pH on the structure of PAMAM dendrimers
    • Maiti, P. K. Effect of solvent and pH on the structure of PAMAM dendrimers Macromolecules 2005, 38 (3) 979-991
    • (2005) Macromolecules , vol.38 , Issue.3 , pp. 979-991
    • Maiti, P.K.1
  • 32
    • 33846164122 scopus 로고    scopus 로고
    • Structure and dynamics of DNA-dendrimer complexation: Role of counterions, water, and base pair sequence
    • Maiti, P. K. Structure and dynamics of DNA-dendrimer complexation: role of counterions, water, and base pair sequence Nano Lett. 2006, 6 (11) 2478-2485
    • (2006) Nano Lett. , vol.6 , Issue.11 , pp. 2478-2485
    • Maiti, P.K.1
  • 33
    • 4644293700 scopus 로고    scopus 로고
    • Dendrimers in solution: Insight from theory and simulation
    • Ballauff, M. Dendrimers in solution: insight from theory and simulation Angew. Chem., Int. Ed. 2004, 43 (23) 2998-3020
    • (2004) Angew. Chem., Int. Ed. , vol.43 , Issue.23 , pp. 2998-3020
    • Ballauff, M.1
  • 34
    • 84865414178 scopus 로고    scopus 로고
    • Dendrimer building toolkit: Model building and characterization of various dendrimer architectures
    • Maingi, V. Dendrimer building toolkit: model building and characterization of various dendrimer architectures J. Comput. Chem. 2012, 33 (25) 1997-2011
    • (2012) J. Comput. Chem. , vol.33 , Issue.25 , pp. 1997-2011
    • Maingi, V.1
  • 35
    • 0037465803 scopus 로고    scopus 로고
    • Structure and dimensions of PAMAM/PEG dendrimer-star polymers
    • Hedden, R. C. Structure and dimensions of PAMAM/PEG dendrimer-star polymers Macromolecules 2003, 36 (6) 1829-1835
    • (2003) Macromolecules , vol.36 , Issue.6 , pp. 1829-1835
    • Hedden, R.C.1
  • 36
    • 84899835001 scopus 로고    scopus 로고
    • Performance and scalability study of SUN constellation cluster Ranger using application-based benchmarks
    • In 2008 Conference
    • Kim, B.-D.; Performance and scalability study of SUN constellation cluster Ranger using application-based benchmarks. In TeraGrid 2008 Conference, 2008.
    • (2008) TeraGrid
    • Kim, B.-D.1
  • 37
    • 27344436659 scopus 로고    scopus 로고
    • Scalable molecular dynamics with NAMD
    • Phillips, J. C. Scalable molecular dynamics with NAMD J. Comput. Chem. 2005, 26 (16) 1781-1802
    • (2005) J. Comput. Chem. , vol.26 , Issue.16 , pp. 1781-1802
    • Phillips, J.C.1
  • 38
    • 0029878720 scopus 로고    scopus 로고
    • VMD: Visual molecular dynamics
    • Humphrey, W. VMD: visual molecular dynamics J. Mol. Graphics 1996, 14 (1) 33-38
    • (1996) J. Mol. Graphics , vol.14 , Issue.1 , pp. 33-38
    • Humphrey, W.1
  • 39
    • 0348244547 scopus 로고    scopus 로고
    • All-atom empirical force field for nucleic acids: I. Parameter optimization based on small molecule and condensed phase macromolecular target data
    • Foloppe, N. All-atom empirical force field for nucleic acids: I. Parameter optimization based on small molecule and condensed phase macromolecular target data J. Comput. Chem. 2000, 21 (2) 86-104
    • (2000) J. Comput. Chem. , vol.21 , Issue.2 , pp. 86-104
    • Foloppe, N.1
  • 40
    • 0000214231 scopus 로고    scopus 로고
    • All-atom empirical force field for nucleic acids: II. Application to molecular dynamics simulations of DNA and RNA in solution
    • MacKerell, A. D. All-atom empirical force field for nucleic acids: II. Application to molecular dynamics simulations of DNA and RNA in solution J. Comput. Chem. 2000, 21 (2) 105-120
    • (2000) J. Comput. Chem. , vol.21 , Issue.2 , pp. 105-120
    • Mackerell, A.D.1
  • 41
    • 70450206724 scopus 로고    scopus 로고
    • Gaussian. Inc. Wallingford, CT
    • Frisch, M.; Gaussian 09; Gaussian. Inc.: Wallingford, CT, 2009.
    • (2009) Gaussian 09
    • Frisch, M.1
  • 42
    • 0038407494 scopus 로고    scopus 로고
    • Microscopic protonation equilibria of poly(amidoamine) dendrimers from macroscopic titrations
    • Cakara, D. Microscopic protonation equilibria of poly(amidoamine) dendrimers from macroscopic titrations Macromolecules 2003, 36 (11) 4201-4207
    • (2003) Macromolecules , vol.36 , Issue.11 , pp. 4201-4207
    • Cakara, D.1
  • 43
    • 50349092134 scopus 로고    scopus 로고
    • Molecular dynamics studies of polyethylene oxide and polyethylene glycol: Hydrodynamic radius and shape anisotropy
    • Lee, H. Molecular dynamics studies of polyethylene oxide and polyethylene glycol: hydrodynamic radius and shape anisotropy Biophys. J. 2008, 95 (4) 1590-1599
    • (2008) Biophys. J. , vol.95 , Issue.4 , pp. 1590-1599
    • Lee, H.1
  • 44
    • 0035526029 scopus 로고    scopus 로고
    • Structure and dynamics of the TIP3P, SPC, and SPC/E water models at 298 K
    • Mark, P. Structure and dynamics of the TIP3P, SPC, and SPC/E water models at 298 K J. Phys. Chem. A 2001, 105 (43) 9954-9960
    • (2001) J. Phys. Chem. A , vol.105 , Issue.43 , pp. 9954-9960
    • Mark, P.1
  • 45
    • 36449007836 scopus 로고
    • Constant-pressure molecular-dynamics simulation - The Langevin piston method
    • Feller, S. E. Constant-pressure molecular-dynamics simulation - the Langevin piston method J. Chem. Phys. 1995, 103 (11) 4613-4621
    • (1995) J. Chem. Phys. , vol.103 , Issue.11 , pp. 4613-4621
    • Feller, S.E.1
  • 46
    • 0034817509 scopus 로고    scopus 로고
    • Langevin stabilization of molecular dynamics
    • Izaguirre, J. A. Langevin stabilization of molecular dynamics J. Chem. Phys. 2001, 114 (5) 2090-2098
    • (2001) J. Chem. Phys. , vol.114 , Issue.5 , pp. 2090-2098
    • Izaguirre, J.A.1
  • 47
    • 33846823909 scopus 로고
    • Particle mesh Ewald: An N ·log(N) method for Ewald sums in large systems
    • Darden, T. Particle mesh Ewald: An N ·log(N) method for Ewald sums in large systems J. Chem. Phys. 1993, 98 (12) 10089-10092
    • (1993) J. Chem. Phys. , vol.98 , Issue.12 , pp. 10089-10092
    • Darden, T.1
  • 48
    • 79955590191 scopus 로고    scopus 로고
    • version 5; Gaussian, Inc. Wallingford, CT
    • Dennington, R.; Gaussview, version 5; Gaussian, Inc.: Wallingford, CT, 2009.
    • (2009) Gaussview
    • Dennington, R.1
  • 49
    • 84872165093 scopus 로고    scopus 로고
    • In vivo distribution and toxicity of PAMAM dendrimers in the central nervous system depend on their surface chemistry
    • Albertazzi, L. In vivo distribution and toxicity of PAMAM dendrimers in the central nervous system depend on their surface chemistry Mol. Pharmaceutics 2012, 10 (1) 249-260
    • (2012) Mol. Pharmaceutics , vol.10 , Issue.1 , pp. 249-260
    • Albertazzi, L.1
  • 50
    • 0037158530 scopus 로고    scopus 로고
    • Dynamics of star-burst dendrimers in solution in relation to their structural properties
    • Rathgeber, S. Dynamics of star-burst dendrimers in solution in relation to their structural properties J. Chem. Phys. 2002, 117 (8) 4047-4062
    • (2002) J. Chem. Phys. , vol.117 , Issue.8 , pp. 4047-4062
    • Rathgeber, S.1
  • 51
    • 19944403601 scopus 로고    scopus 로고
    • Dynamics and thermodynamics of water in PAMAM dendrimers at subnanosecond time scales
    • Lin, S.-T. Dynamics and thermodynamics of water in PAMAM dendrimers at subnanosecond time scales J. Phys. Chem. B 2005, 109 (18) 8663-8672
    • (2005) J. Phys. Chem. B , vol.109 , Issue.18 , pp. 8663-8672
    • Lin, S.-T.1
  • 52
    • 33846386149 scopus 로고    scopus 로고
    • Solvent quality changes the structure of G8 PAMAM dendrimer, a disagreement with some experimental interpretations
    • Maiti, P. K. Solvent quality changes the structure of G8 PAMAM dendrimer, a disagreement with some experimental interpretations J. Phys. Chem. B 2006, 110 (51) 25628-25632
    • (2006) J. Phys. Chem. B , vol.110 , Issue.51 , pp. 25628-25632
    • Maiti, P.K.1
  • 53
    • 47949114483 scopus 로고    scopus 로고
    • Counterion distribution and -potential in PAMAM dendrimer
    • Maiti, P. K. Counterion distribution and -potential in PAMAM dendrimer Macromolecules 2008, 41 (13) 5002-5006
    • (2008) Macromolecules , vol.41 , Issue.13 , pp. 5002-5006
    • Maiti, P.K.1
  • 54
    • 72049085295 scopus 로고    scopus 로고
    • Diffusion of flexible, charged, nanoscopic molecules in solution: Size and pH dependence for PAMAM dendrimer
    • Maiti, P. K. Diffusion of flexible, charged, nanoscopic molecules in solution: size and pH dependence for PAMAM dendrimer J. Chem. Phys. 2009, 131 (21) 214901
    • (2009) J. Chem. Phys. , vol.131 , Issue.21 , pp. 214901
    • Maiti, P.K.1
  • 55
    • 65249170865 scopus 로고    scopus 로고
    • Structure of polyamidoamide dendrimers up to limiting generations: A mesoscale description
    • Maiti, P. K. Structure of polyamidoamide dendrimers up to limiting generations: a mesoscale description J. Chem. Phys. 2009, 130 (14) 144902
    • (2009) J. Chem. Phys. , vol.130 , Issue.14 , pp. 144902
    • Maiti, P.K.1
  • 56
    • 80455132530 scopus 로고    scopus 로고
    • Molecular dynamics studies of the size and internal structure of the PAMAM dendrimer grafted with arginine and histidine
    • Lee, H. Molecular dynamics studies of the size and internal structure of the PAMAM dendrimer grafted with arginine and histidine Macromolecules 2011, 44 (21) 8681-8686
    • (2011) Macromolecules , vol.44 , Issue.21 , pp. 8681-8686
    • Lee, H.1
  • 57
    • 33645661280 scopus 로고    scopus 로고
    • Molecular dynamics studies of the size, shape, and internal structure of 0% and 90% acetylated fifth-generation polyamidoamine dendrimers in water and methanol
    • Lee, H. Molecular dynamics studies of the size, shape, and internal structure of 0% and 90% acetylated fifth-generation polyamidoamine dendrimers in water and methanol J. Phys. Chem. B 2006, 110 (9) 4014-4019
    • (2006) J. Phys. Chem. B , vol.110 , Issue.9 , pp. 4014-4019
    • Lee, H.1
  • 58
    • 70349696667 scopus 로고    scopus 로고
    • Molecular dynamics study of the structure and interparticle interactions of polyethylene glycol-conjugated PAMAM dendrimers
    • Lee, H. Molecular dynamics study of the structure and interparticle interactions of polyethylene glycol-conjugated PAMAM dendrimers J. Phys. Chem. B 2009, 113 (40) 13202-13207
    • (2009) J. Phys. Chem. B , vol.113 , Issue.40 , pp. 13202-13207
    • Lee, H.1
  • 59
    • 59349091273 scopus 로고    scopus 로고
    • Multiscale modeling of dendrimers and their interactions with bilayers and polyelectrolytes
    • Lee, H. Multiscale modeling of dendrimers and their interactions with bilayers and polyelectrolytes Molecules 2009, 14 (1) 423-438
    • (2009) Molecules , vol.14 , Issue.1 , pp. 423-438
    • Lee, H.1
  • 60
    • 79953880810 scopus 로고    scopus 로고
    • Effects of PEGylation on the size and internal structure of dendrimers: Self-penetration of long PEG chains into the dendrimer core
    • Lee, H. Effects of PEGylation on the size and internal structure of dendrimers: self-penetration of long PEG chains into the dendrimer core Macromolecules 2011, 44 (7) 2291-2298
    • (2011) Macromolecules , vol.44 , Issue.7 , pp. 2291-2298
    • Lee, H.1
  • 61
    • 0013373034 scopus 로고    scopus 로고
    • Oxford University Press: Oxford, UK
    • Rubinstein, M.; Polymer Physics; Oxford University Press: Oxford, UK, 2003.
    • (2003) Polymer Physics
    • Rubinstein, M.1
  • 62
    • 77149132455 scopus 로고    scopus 로고
    • Intramolecular structural change of PAMAM dendrimers in aqueous solutions revealed by small-angle neutron scattering
    • Porcar, L. Intramolecular structural change of PAMAM dendrimers in aqueous solutions revealed by small-angle neutron scattering J. Phys. Chem. B 2010, 114 (5) 1751-1756
    • (2010) J. Phys. Chem. B , vol.114 , Issue.5 , pp. 1751-1756
    • Porcar, L.1
  • 63
    • 0035800279 scopus 로고    scopus 로고
    • From stars to spheres: A SAXS analysis of dilute dendrimer solutions
    • Prosa, T. J. From stars to spheres: A SAXS analysis of dilute dendrimer solutions Macromolecules 2001, 34 (14) 4897-4906
    • (2001) Macromolecules , vol.34 , Issue.14 , pp. 4897-4906
    • Prosa, T.J.1
  • 64
    • 33846030808 scopus 로고    scopus 로고
    • Attenuating electron-transfer rates via dendrimer encapsulation: The case of metal tris (bipyridine) core dendrimers
    • Hong, Y.-R. Attenuating electron-transfer rates via dendrimer encapsulation: the case of metal tris (bipyridine) core dendrimers Langmuir 2006, 22 (25) 10506-10509
    • (2006) Langmuir , vol.22 , Issue.25 , pp. 10506-10509
    • Hong, Y.-R.1
  • 65
    • 0035862130 scopus 로고    scopus 로고
    • 4] cores: Implications for the DMSO reductase family of enzymes
    • 4] cores: implications for the DMSO reductase family of enzymes Inorg. Chem. 2001, 40 (2) 192-193
    • (2001) Inorg. Chem. , vol.40 , Issue.2 , pp. 192-193
    • Mondal, S.1
  • 66
    • 57349107307 scopus 로고    scopus 로고
    • Assess the intramolecular cavity of a PAMAM dendrimer in aqueous solution by small-angle neutron scattering
    • Li, T. Assess the intramolecular cavity of a PAMAM dendrimer in aqueous solution by small-angle neutron scattering Macromolecules 2008, 41 (22) 8916-8920
    • (2008) Macromolecules , vol.41 , Issue.22 , pp. 8916-8920
    • Li, T.1
  • 67
    • 84871952514 scopus 로고    scopus 로고
    • Theoretical and computational studies of dendrimers as delivery vectors
    • Ma, Y.-q. Theoretical and computational studies of dendrimers as delivery vectors Chem. Soc. Rev. 2013, 42 (2) 705-727
    • (2013) Chem. Soc. Rev. , vol.42 , Issue.2 , pp. 705-727
  • 68
    • 33644593095 scopus 로고    scopus 로고
    • PAMAM dendrimer-based multifunctional conjugate for cancer therapy: Synthesis, characterization, and functionality
    • Majoros, I. J. PAMAM dendrimer-based multifunctional conjugate for cancer therapy: synthesis, characterization, and functionality Biomacromolecules 2006, 7 (2) 572-579
    • (2006) Biomacromolecules , vol.7 , Issue.2 , pp. 572-579
    • Majoros, I.J.1
  • 69
    • 28744440082 scopus 로고    scopus 로고
    • Dendrimers in gene delivery
    • Dufes, C. Dendrimers in gene delivery Adv. Drug Delivery Rev. 2005, 57 (15) 2177-2202
    • (2005) Adv. Drug Delivery Rev. , vol.57 , Issue.15 , pp. 2177-2202
    • Dufes, C.1
  • 70
    • 12844258906 scopus 로고    scopus 로고
    • Dendrimers and dendritic polymers in drug delivery
    • Gillies, E. R. Dendrimers and dendritic polymers in drug delivery Drug Discovery Today 2005, 10 (1) 35-43
    • (2005) Drug Discovery Today , vol.10 , Issue.1 , pp. 35-43
    • Gillies, E.R.1
  • 71
    • 0027957863 scopus 로고
    • Dendrimer-based metal chelates: A new class of magnetic resonance imaging contrast agents
    • Wiener, E. Dendrimer-based metal chelates: a new class of magnetic resonance imaging contrast agents Magn. Reson. Med. 1994, 31 (1) 1-8
    • (1994) Magn. Reson. Med. , vol.31 , Issue.1 , pp. 1-8
    • Wiener, E.1
  • 72
    • 84859827353 scopus 로고    scopus 로고
    • Surface conjugation of triphenylphosphonium to target poly(amidoamine) dendrimers to mitochondria
    • Biswas, S. Surface conjugation of triphenylphosphonium to target poly(amidoamine) dendrimers to mitochondria Biomaterials 2012, 33 (18) 4773-4782
    • (2012) Biomaterials , vol.33 , Issue.18 , pp. 4773-4782
    • Biswas, S.1
  • 73
    • 0037044378 scopus 로고    scopus 로고
    • Distribution of end groups within a dendritic structure: A SANS study including contrast variation
    • Rosenfeldt, S. Distribution of end groups within a dendritic structure: A SANS study including contrast variation Macromolecules 2002, 35 (21) 8098-8105
    • (2002) Macromolecules , vol.35 , Issue.21 , pp. 8098-8105
    • Rosenfeldt, S.1
  • 74
    • 0031042727 scopus 로고    scopus 로고
    • Shapes of dendrimers from Rotational-Echo Double-Resonnance NMR
    • Wooley, K. L. Shapes of dendrimers from Rotational-Echo Double-Resonnance NMR J. Am. Chem. Soc. 1997, 119 (1) 53-58
    • (1997) J. Am. Chem. Soc. , vol.119 , Issue.1 , pp. 53-58
    • Wooley, K.L.1
  • 75
    • 0037161405 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible high-efficiency DNA Delivery
    • Luo, D. Poly(ethylene glycol)-conjugated PAMAM dendrimer for biocompatible high-efficiency DNA Delivery Macromolecules 2002, 35 (9) 3456-3462
    • (2002) Macromolecules , vol.35 , Issue.9 , pp. 3456-3462
    • Luo, D.1
  • 76
    • 0037124545 scopus 로고    scopus 로고
    • Intranasal gene delivery with a polyethylenimine-PEG conjugate
    • Kichler, A. Intranasal gene delivery with a polyethylenimine-PEG conjugate J. Controlled Release 2002, 81 (3) 379-388
    • (2002) J. Controlled Release , vol.81 , Issue.3 , pp. 379-388
    • Kichler, A.1
  • 77
    • 0037362655 scopus 로고    scopus 로고
    • Effect of PEGylation on pharmaceuticals
    • Harris, J. M. Effect of PEGylation on pharmaceuticals Nat. Rev. Drug Discovery 2003, 2 (3) 214-221
    • (2003) Nat. Rev. Drug Discovery , vol.2 , Issue.3 , pp. 214-221
    • Harris, J.M.1
  • 78
    • 56749185962 scopus 로고    scopus 로고
    • Folate and folate-PEG-PAMAM dendrimers: Synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice
    • Singh, P. Folate and folate-PEG-PAMAM dendrimers: synthesis, characterization, and targeted anticancer drug delivery potential in tumor bearing mice Bioconjugate Chem. 2008, 19 (11) 2239-2252
    • (2008) Bioconjugate Chem. , vol.19 , Issue.11 , pp. 2239-2252
    • Singh, P.1
  • 79
    • 36549034234 scopus 로고    scopus 로고
    • Polymers and nanoparticles: Intelligent tools for intracellular targeting?
    • Breunig, M. Polymers and nanoparticles: intelligent tools for intracellular targeting? Eur. J. Pharm. Biopharm. 2008, 68 (1) 112-128
    • (2008) Eur. J. Pharm. Biopharm. , vol.68 , Issue.1 , pp. 112-128
    • Breunig, M.1
  • 80
    • 0016932916 scopus 로고
    • Thermal equilibrium of the intermacromolecular complexes of polycarboxylic acids realized by cooperative hydrogen bonding
    • Osada, Y. Thermal equilibrium of the intermacromolecular complexes of polycarboxylic acids realized by cooperative hydrogen bonding J. Polym. Sci.: Polym. Lett. 1976, 14 (3) 129-134
    • (1976) J. Polym. Sci.: Polym. Lett. , vol.14 , Issue.3 , pp. 129-134
    • Osada, Y.1
  • 81
    • 78449252867 scopus 로고    scopus 로고
    • PEGylated poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors
    • He, H. PEGylated poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors Biomaterials 2011, 32 (2) 478-487
    • (2011) Biomaterials , vol.32 , Issue.2 , pp. 478-487
    • He, H.1
  • 82
    • 72149091705 scopus 로고    scopus 로고
    • Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: The effects of PEGylation degree and drug conjugation style
    • Zhu, S. Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style Biomaterials 2010, 31 (6) 1360-1371
    • (2010) Biomaterials , vol.31 , Issue.6 , pp. 1360-1371
    • Zhu, S.1


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