Synthesis and secretion of active α1-antichymotrypsin by murine primary astrocytes

Neurobiology of Aging

Volumn 17, Issue 5, 1996, Pages 767-771

  Kanemaru, Kazutomi ^a,b   Meckelein, Barbara ^a   Marshall, Derek C L ^a   Sipe, Jean D ^a   Abraham, Carmela R ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Tokyo Metropolitan Institute of Gerontology   (Japan)

Author keywords

Active phase; Alzheimer's disease; Glia; Inflammation; Reactive astrocytes; Serine protease inhibitor

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0030250789     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(96)00111-X     Document Type: Article

References (30)

1. 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell 52:487-501; 1988.
2. 1-Antichymotrypsin is present together with the β-protein in monkey brain amyloid deposits. Neuroscience 32:715-720; 1989.
3. 1-antichymotrypsin is associated solely with amyloid deposits containing the β-protein and is localized in specific cells of both normal and diseased brain. Neurobiol. Aging 11:123-129; 1990.
4. 1-antichymotrypsin in brain dysfunction and injury. Res. Immunol. 143:631-636; 1992.
5. 1-antichymotrypsin like proteins in reactive astrocytes. Brain Res. 621:222-232; 1993.
6. 6. Campbell, I. L.; Abraham, C. R.; Kemper, P.; Inglis, J. D.; Oldstone, M. B. A.; Mucke, L. Neurologic disease induced in transgenic mice by the astrocyte-specific expression of the cytokine interleukin-6. Proc. Natl. Acad. Sci. USA 90:10061-10065; 1993.
7. 1 antichymotrypsin is induced in human astrocytes by IL-1. Neuron 14:447-456; 1995.
8. 8. Eikelenboom, P.; Rozemuller, J. M.; Kraal, G.; Stam, F. C.; McBride, P. A.; Bruce, M. E.; Fraser, H. Cerebral amyloid plaques in Alzheimer's disease but not in scrapie-affected mice are closely associated with a local inflammatory process. Virchows Arch. B. 60:329-331; 1991.
9. 9. Games, D.; Adams, D.; Alessandrini, R.; Barbour, R.; Berthelette, P.; Blackwell, C.; Carr, T.; Clemens, J.; Donaldson, R.; Gillespie, F.; Guido, T.; Hagopian, S.; Johnson-Wood, K.; Khan, K.; Lee, M.; Leibowitz, P.; Lieberburg, I.; Little, S.; Masliah, E.; McConlogue, L.; Montoya-Zavala, M.; Mucke, L.; Paganini, L.; Penniman, E. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373:523-527; 1995.
10. 10. Griffin, W. S. T.; Sheng, J. G.; Roberts, G. W.; Mrak, R. E. Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution. J. Neuropathol. Exp. Neurol. 54: 276-281; 1995.
11. 11. Hudig, D.; Redelman, D.; Minning. L. L. The requirement for proteinase activity for human lymphocyte-mediated natural cytotoxicity (NK); Evidence that the proteinase is serine dependent and has aromatic amino acid specificity of cleavage. J. Immunol. 133:2647-2754; 1984.
12. 1-antichymotrypsin-like proteins in a murine chondrocytic cell line. Gene 106:213-220; 1991.
13. 13. Kanemaru, K.; Abraham, C. R. Synthesis and secretion of active alpha 1-antichymotrypsin by murine astrocytes. Soc. Neurosci. Abstr. 18: 1440; 1992.
14. 14. Koj, A.; Magielska-Zero, D.; Kurdowska, A.; Bereta, J. Proteinase inhibitors as acute phase reactants; Regulation of synthesis and turnover. Adv. Exp. Med. Biol. 240:171-181; 1988.
15. 1 antichymotrypsin in brain may be related to astrogliosis. Neurobiol. Aging 12:495-501; 1991.
16. 1-antichymotrypsin-cathepsin G complexes. J. Biol. Chem. 265:21023-21026; 1990.
17. 17. McCarthy, K. D.; de Vellis, J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85:890-902; 1980.
18. 18. Mrak, R. E.; Sheng, J. G.; Griffin, W. S. T. Glial cytokines in Alzheimer's disease. Hum. Pathol. 26:816-823; 1995.
19. 1-antichymotrypsin. J. Biol. Chem. 265: 3836-3843; 1990.
20. 1antitrypsin in haematopoietic and lymphoid tissue cells are revealed by the immunoperoxidase method. Pathol. Res. Pract. 169:287-297; 1980.
21. 1-antichymotrypsin mRNA. Am. J. Pathol. 135:827-834; 1989.
22. 1-antichymotrypsin in cerebral and systemic amyloid. J. Neuropathol. Exp. Neurol. 49:41-48; 1990.
23. 1-antichymotrypsin in plaques and vascular amyloid in Alzheimer's disease. Acta Neuropathol. 82:200-207; 1991.
24. 24. Seubert, P.; Vigo-Pelfrey, C.; Esch, F.; Lee, M.; Dovey, H.; Davis, D.; Sinha, S.; Schlossmacher, M.; Whaley, J.; Swindlehurst, C.; McCormack, R.; Wolfert, R.; Selkoe, D. J.; Lieberburg, I.; Schenk, D. Isolation and quantification of soluble Alzheimer's β peptide from biological fluids. Nature 359:325-327; 1992.
25. 1-Antichymotrypsin is present in diffuse senile plaques. Am. J. Pathol. 138:247-257; 1991.
26. 26. Siman, R.; Card, J. P.; Nelson, R. B.; Davis, L. G. Expression of β-amyloid precursor protein in reactive astrocytes. Neuron 3:275-285; 1989.
27. 1-antichymotrypsin in Alzhemer's brain, compared to β-amyloid precursor protein and β-amyloid protein. J. Neurol. Sci. 99:301-310; 1990.
28. 28. Travis, J.; Salvesen, G. Human plasma proteinase inhibitors. Annu. Rev. Biochem 52:655-709; 1983.
29. 1-antichymotrypsin; Purification and properties. Biochemistry 17:5647-5651; 1978.
30. 30. Travis, J.; Gudzek, A.; Potempa, J.; Watorek, W. Serpins: Structure and mechanism of action. Biol. Chem. Hoppe-Seyler 371:3-11; 1990.