Complex formation between s100b protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signalregulated kinase (ERK)-mediated phosphorylation of RSK

Journal of Biological Chemistry

Volumn 289, Issue 18, 2014, Pages 12886-12895

  Hartman, Kira G ^a   Vitolo, Michele I ^a,c   Pierce, Adam D ^a   Fox, Jennifer M ^a   Shapiro, Paul ^b,c   Martin, Stuart S ^a   Wilder, Paul T ^a,c   Weber, David J ^a,c  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DERMATOLOGY; ENZYMES; PHOSPHORYLATION;

CANCER PROGRESSION; COMPLEX FORMATIONS; CYTOSOLS; EXTRACELLULAR SIGNAL-REGULATED KINASE; MALIGNANT MELANOMA; P90 RIBOSOMAL S6 KINASE; SIGNALING PATHWAYS;

ONCOLOGY;

CALPAIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P90; PROTEIN S100B; S6 KINASE; THREONINE; THREONINE 573; UNCLASSIFIED DRUG;

ARTICLE; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER STAGING; CARBOXY TERMINAL SEQUENCE; CELL FRACTIONATION; CELL SURVIVAL; CELL VIABILITY; COMPLEX FORMATION; CYTOSOL; HUMAN; MELANOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CALCIUM; CALCIUM BINDING PROTEINS; CANCER; ERK; MAP KINASES (MAPKS); MELANOMA; RSK; S100 PROTEINS;

BLOTTING, WESTERN; CALCIUM; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; CYTOSOL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MELANOMA; MICROSCOPY, CONFOCAL; MULTIPROTEIN COMPLEXES; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; RNA INTERFERENCE; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; THREONINE;

EID: 84899761942     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.561613     Document Type: Article

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