Target binding to S100B reduces dynamic properties and increases Ca 2 +-binding affinity for wild type and EF-hand mutant proteins

Journal of Molecular Biology

Volumn 423, Issue 3, 2012, Pages 365-385

  Liriano, Melissa A ^a   Varney, Kristen M ^a   Wright, Nathan T ^a   Hoffman, Cassandra L ^a   Toth, Eric A ^a   Ishima, Rieko ^b   Weber, David J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

EF hand; NMR; relaxation dispersion; S100 proteins

Indexed keywords

ASPARTIC ACID; MUTANT PROTEIN; PROTEIN S100B;

ARTICLE; BINDING AFFINITY; CALCIUM BINDING; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN STRUCTURE; THERMODYNAMICS; WILD TYPE; X RAY CRYSTALLOGRAPHY;

EID: 84867085738     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2012.07.011     Document Type: Article

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