S100 proteins interact with the N-terminal domain of MDM2

FEBS Letters

Volumn 584, Issue 15, 2010, Pages 3269-3274

  van Dieck, Jan ^a   Lum, Jenifer K ^a   Teufel, Daniel P ^a   Fersht, Alan R ^a  

^a MRC CENTRE FOR PROTEIN ENGINEERING   (United Kingdom)

Author keywords

MDM2; P53; Protein protein interaction; S100; Ternary complex

Indexed keywords

CALCYCLIN; CALVASCULIN; PROTEIN MDM2; PROTEIN P53; PROTEIN S 100; PROTEIN S100A1; PROTEIN S100A2; PROTEIN S100B; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; UBIQUITINATION;

BINDING SITES; BIOTINYLATION; CHROMATOGRAPHY, GEL; HUMANS; LIGHT; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MDM2; S100 PROTEINS; SCATTERING, RADIATION; SURFACE PLASMON RESONANCE; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 77955278428     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.06.024     Document Type: Article

References (23)

1. Donato R. Intracellular and extracellular roles of S100 proteins. Microsc. Res. Tech. 2003, 60:540-551.
2. Leclerc E., Fritz G., Vetter S.W., Heizmann C.W. Binding of S100 proteins to RAGE: an update. Biochim. Biophys. Acta 2009, 1793:993-1007.
3. Santamaria-Kisiel L., Rintala-Dempsey A.C., Shaw G.S. Calcium-dependent and -independent interactions of the S100 protein family. Biochem. J. 2006, 396:201-214.
4. Salama I., Malone P.S., Mihaimeed F., Jones J.L. A review of the S100 proteins in cancer. Eur. J. Surg. Oncol. 2008, 34:357-364.
5. Bonfrer J.M., Korse C.M., Nieweg O.E., Rankin E.M. The luminescence immunoassay S-100: a sensitive test to measure circulating S-100B: its prognostic value in malignant melanoma. Br. J. Cancer 1998, 77:2210-2214.
6. Davies M.P., Rudland P.S., Robertson L., Parry E.W., Jolicoeur P., Barraclough R. Expression of the calcium-binding protein S100A4 (p9Ka) in MMTV-neu transgenic mice induces metastasis of mammary tumours. Oncogene 1996, 13:1631-1637.
7. Ambartsumian N.S., Grigorian M.S., Larsen I.F., Karlstrom O., Sidenius N., Rygaard J., Georgiev G., Lukanidin E. Metastasis of mammary carcinomas in GRS/A hybrid mice transgenic for the mts1 gene. Oncogene 1996, 13:1621-1630.
8. Fernandez-Fernandez M.R., Rutherford T.J., Fersht A.R. Members of the S100 family bind p53 in two distinct ways. Protein Sci. 2008, 17:1663-1670.
9. Fernandez-Fernandez M.R., Veprintsev D.B., Fersht A.R. Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor. Proc. Natl. Acad. Sci. USA 2005, 102:4735-4740.
10. van Dieck J., Fernandez-Fernandez M.R., Veprintsev D.B., Fersht A.R. Modulation of the oligomerization state of p53 by differential binding of proteins of the S100 family to p53 monomers and tetramers. J. Biol. Chem. 2009, 284:13804-13811.
11. van Dieck J., Teufel D.P., Jaulent A.M., Fernandez-Fernandez M.R., Rutherford T.J., Wyslouch-Cieszynska A., Fersht A.R. Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53. J. Mol. Biol. 2009, 394:922-930.
12. Scotto C., Deloulme J.C., Rousseau D., Chambaz E., Baudier J. Calcium and S100B regulation of p53-dependent cell growth arrest and apoptosis. Mol. Cell. Biol. 1998, 18:4272-4281.
13. Scotto C., Delphin C., Deloulme J.C., Baudier J. Concerted regulation of wild-type p53 nuclear accumulation and activation by S100B and calcium-dependent protein kinase C. Mol. Cell. Biol. 1999, 19:7168-7180.
14. Lin J., Blake M., Tang C., Zimmer D., Rustandi R.R., Weber D.J., Carrier F. Inhibition of p53 transcriptional activity by the S100B calcium-binding protein. J. Biol. Chem. 2001, 276:35037-35041.
15. Mueller A., Schafer B.W., Ferrari S., Weibel M., Makek M., Hochli M., Heizmann C.W. The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity. J. Biol. Chem. 2005, 280:29186-29193.
16. Slomnicki L.P., Nawrot B., Lesniak W. S100A6 binds p53 and affects its activity. Int. J. Biochem. Cell Biol. 2009, 41:784-790.
17. Momand J., Wu H.H., Dasgupta G. MDM2-master regulator of the p53 tumor suppressor protein. Gene 2000, 242:15-29.
18. Wilder P.T., et al. Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Biochim. Biophys. Acta 2006, 1763:1284-1297.
19. Schon O., Friedler A., Bycroft M., Freund S.M., Fersht A.R. Molecular mechanism of the interaction between MDM2 and p53. J. Mol. Biol. 2002, 323:491-501.
20. Yu G.W., Rudiger S., Veprintsev D., Freund S., Fernandez-Fernandez M.R., Fersht A.R. The central region of HDM2 provides a second binding site for p53. Proc. Natl. Acad. Sci. USA 2006, 103:1227-1232.
21. Ang H.C., Joerger A.C., Mayer S., Fersht A.R. Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains. J. Biol. Chem. 2006, 281:21934-21941.
22. Ferreon J.C., Lee C.W., Arai M., Martinez-Yamout M.A., Dyson H.J., Wright P.E. Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. Proc. Natl. Acad. Sci. USA 2009, 106:6591-6596.
23. Toledo F., Wahl G.M. MDM2 and MDM4: p53 regulators as targets in anticancer therapy. Int. J. Biochem. Cell Biol. 2007, 39:1476-1482.