S100b(ββ) inhibits the protein kinase C-dependent phosphorylation of a peptide derived from p53 in a Ca2+-dependent manner

Protein Science

Volumn 7, Issue 3, 1998, Pages 794-798

  Wilder, Paul T ^a   Rustandi, Richard R ^a   Drohat, Alexander C ^a   Weber, David J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium binding protein; P53; Phosphorylation; PKM; Protein kinase C; S100 protein; S100B

Indexed keywords

CALCIUM BINDING PROTEIN; CALCIUM ION; NEUROMODULIN; PROTEIN KINASE C; PROTEIN P53; CALCIUM; NERVE GROWTH FACTOR; PEPTIDE FRAGMENT; PROTEIN S 100; RECOMBINANT PROTEIN; S 100 CALCIUM BINDING PROTEIN BETA SUBUNIT; S-100 CALCIUM-BINDING PROTEIN BETA SUBUNIT;

ARTICLE; ENZYME ACTIVE SITE; ENZYME SUBUNIT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; AMINO ACID SEQUENCE; ANIMAL; DRUG ANTAGONISM; ENZYME SPECIFICITY; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY; RAT; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM; GAP-43 PROTEIN; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RECOMBINANT PROTEINS; S100 PROTEINS; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031594590     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560070330     Document Type: Article

References (37)

1. Albert KA, Wu WC-S, Nairn AC, Greengard P. 1984. Inhibition by calmodulin of calcium/phospholipid-dependent protein phosphorylation. Proc Natl Acad Sci USA 81:3622-3625.
2. 15N NMR assignments and solution secondary structure of rat Apo-S100β. J Biomol NMR 6:171-179.
3. Baudier J, Bergere E, Bertacchi N, Weintraub H, Gagnon J, Garin J. 1995. Interaction of myogenic bHLH transcription factors with calcium-binding calmodulin and S100a(αα) proteins. Biochemistry 34:7834-7846.
4. Baudier J, Delphin C, Grundwald D, Khochbin S, Lawrence JJ. 1992. Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100B-binding protein. Proc Natl Acad Sci USA 89:11627-11631.
5. Baudier J, Mochly-Rosen D, Newton A, Lee S-H. Koshland DE, Cole RD. 1987. Comparison of S100B protein with calmodulin: Interactions with melittin and microtubule-associated τ proteins and inhibition of phosphorylation of τ proteins by protein kinase C. Biochemistry 26:2886-2893.
6. Baudier J, Glasser N, Gerard D. 1986. Ions binding to S100 proteins. J Biol Chem 261:8192-8203.
7. +2-dependent manner. J Biol Chem 265:12669-12674.
8. Bianchi R, Verzini M, Garbuglia M, Giambanco I, Donato R. 1994. Mechanism of S100 protein-dependent inhibition of glial fibrillary acidic protein (GFAP) polymerization. Biochim Biophys Acta 1223:354-360.
9. Burns DJ, Bloomenthal J, Lee M-H, Beel RM. 1990. Expression of the a, bII, and g PKC isozymes in the baculovirus insect cell expression system. J Biol Chem 265:12044-12051.
10. Chaudhuri D, Horrocks WW, Amburgey JC, Weber DJ. 1997. Characterization of lanthanide ion binding to the EF hand protein S100β by luminescence spectroscopy. Biochemistry 36:9674-9680.
11. Donato R. 1991. Perspectives in S-100 protein biology. Cell Calcium 12:713-726.
12. Drohat AC, Amburgey JC, Abildgaard F, Starich MR, Baldisseri D, Weber DJ. 1996. Solution structure of rat Apo-S100B(ββ) as determined by NMR spectroscopy. Biochemistry 35:11577-11588.
13. Drohat AC, Nenortas E, Becken D, Weber DJ. 1997. Oligomerization state of S100B(ββ) at nanomolar concentration determined by large-zone analytical gel filtration chromatography. Protein Sci 6:1577-1582.
14. Graff JM, Rajan RR, R. RR, Nairn AC, Blackshear PJ. 1991. Protein kinase C substrate and inhibitor characteristics of peptides derived from the myristoylated alanine-rich C kinase substrate (MARCKS) protein phosphorylation site domain. J Biol Chem 266:14390-14398.
15. Graff JM, Young TN, Johnson JD, Blackshear PJ. 1989. Phosphorylation-regulated calmodulin binding to prominent cellular substrate for protein kinase C. J Biol Chem 264:21818-21823.
16. House C, Kemp BE. 1987. Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238:1726-1728.
17. House C, Richard EH, Wettenhal REH, Kemp BE. 1987. The influence of basic residues on the substrate specificity of protein kinase C. J Biol Chem 262:772-777.
18. Ivanenkov VV, Jamieson GAJ, Gruenstein E. Dimlich RVW. 1995. Characterization of S100B binding epitopes. Identification of a novel target, the actin capping protein, CapZ. J Biol Chem 270:14651-14658.
19. Kemp BE, Pearson RB. 1991. Design and use of peptide substrates for protein kinases. Methods Enzymol 200:121-134.
20. Kilby PM, Van Eldik LJ. Roberts GCK. 1996. The solution structure of the bovine S100B protein dimer in the calcium-free state. Structure 4:1041-1052.
21. Kligman D, Hilt D. 1988. The S100 protein family. Trends Biochem Sci 13:437-443.
22. Lin L-H, Van Eldik LJ, Osheroff N, Nordon JJ. 1994. Inhibition of protein kinase C-and casein kinase II-mediated phosphorylation of GAP-43 by S100β. Mol Brain Res 25:297-304.
23. McIlroy BK, Walters JD, Blackshear PJ, Johnson JD. 1991. Phosphorylation-dependent binding of a synthetic MARCKS peptide to calmodulin. J Biol Chem 266:4959-4964.
24. Moore B. 1965. A soluble protein characteristic of the nervous system. Biochem Biophys Res Commun 19:739-744.
25. Patel J, Marangos PJ, Heydorn WE, Chang G, Verma A, Jacobowitz D. 1983. S-100-Mediated inhibition of brain protein phosphorylation. J Neurochem 41:1040-1045.
26. Roskoski R, Jr. 1983. Assays of protein kinase. Methods Enzymol 99:3-6.
27. +2-dependent interaction of S100B(ββ) with a peptide derived from p53. Biochemistry, in press.
28. Schafer BW,. Heizmann CW. 1996. The S100 family of EF-hand calcium-binding proteins: Functions and pathology. Trends Biochem Sci 21:134-140.
29. Schleiff E, Schmitz A, McIlhinney RAJ, Manenti S, Vergeres G. 1996. Myristoylation does not modulate the properties of MARCKS-related protein (MRP) in solution. J Biol Chem 27;:26794-26802.
30. Sheu F-S, Azmitia EC, Marshak DR, Parker PK, Routtenberg A. 1994. Glial-derived S100b protein selectively inhibits recombinant β protein kinase C (PKC) phosphorylation of neuron-specific protein F1/GAP43. Mol Brain Res 21:62-66.
31. Sheu F-S, Huang FL, Huang K-P. 1995. Differential responses of protein kinase C substrates (MARCKS, neuromodulin, and neurogranin) phosphorylation to calmodulin and S100. Arch Biochem Biophys 316:335-342.
32. Smith SP, Barber KR, Shaw GS. 1997. Use of a differentially modified N-terminal methionine to analyze tertiary structure and conformational changes in human S100b. Protein Sci 6:1110-1113.
33. Suzushima H, N. A, Hattori T, Takatasuki K. 1994. Adult T-cell leukemia derived from S100 beta positive double-negative (CD4-CD8-) T cells. Leuk Lymphoma 13:257-262.
34. Takashi M, Sakata T, Nakano Y, Yamada Y, Miyake K, Kato K. 1994. Elevated concentrations of the beta-subunit of S100 protein in renal cell tumors in rats. Urol Res 22:251-255.
35. Verghese GM, Johnson JD, Vasulka C, Haupt DM, Stumpo DJ, Blackshear PJ. 1994. Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein. J Biol Chem 269:9361-9367.
36. Wilder PT, Weber DJ. 1996. S100β Inhibition of PKCα and PKM phosphorylation of a synthetic peptide derived from p53. Biophys J 70:A62.
37. Zimmer DB, Cornwall EH, Landar A, Song W. 1995. The S100 protein family: History, function, and expression. Brain Res Bull 37:417-429.