Ribosomal S6 kinase-1 modulates interleukin-1+-induced persistent activation of NF-κB through phosphorylation of IκBβ

American Journal of Physiology - Cell Physiology

Volumn 291, Issue 6, 2006, Pages

  Xu, Shanqin ^a   Bayat, Hossein ^a   Hou, Xiuyun ^a   Jiang, Bingbing ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Extracellular signal regulated kinase; In vitro phosphorylation assay; Recombinant proteins; Small interference RNA; Vascular smooth muscle cell

Indexed keywords

I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; RIBOSOMAL S6 KINASE 1; S6 KINASE; SERINE; SYNAPTOTAGMIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LOCALIZATION; MALE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; UBIQUITINATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; I-KAPPA B PROTEINS; INTERLEUKIN-1BETA; MALE; MAP KINASE SIGNALING SYSTEM; MULTIPROTEIN COMPLEXES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; RNA, SMALL INTERFERING; TRANSCRIPTION FACTOR RELA;

EID: 33845285529     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00552.2005     Document Type: Article

References (30)

1. Baeuerle PA and Henkel T. Function and activation of NF-κB in the immune system. Annu Rev Immunol 12: 141-179, 1994.
2. Baldwin AS Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 14: 649-683, 1996.
3. Brand K, Page S, Walli AK, Neumeier D, and Baeuerle PA. Role of nuclear factor-κB in atherogenesis. Exp Physiol 82: 297-304, 1997.
4. Chen F, Castranova V, Shi X, and Demers LM. New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 45: 7-17, 1999.
5. Cheshire JL and Baldwin AS Jr. Synergistic activation of NF-κB by tumor necrosis factor α and γ interferon via enhanced IκBα degradation and de novo IκBβ degradation. Mol Cell Biol 17: 6746-6754, 1997.
6. DeLuca C, Petropoulos L, Zmeureanu D, and Hiscott J. Nuclear IκBβ maintains persistent NF-κB activation in HIV-1-infected myeloid cells. J Biol Chem 274: 13010-13016, 1999.
7. rsk) phosphorylates the N-terminal regulatory domain of IκBα and stimulates its degradation in vitro. J Biol Chem 272: 21281-21288, 1997.
8. Ghosh S and Baltimore D. Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature 344: 678-682, 1990.
9. Guha M and Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 13: 85-94, 2001.
10. Jiang B and Brecher P. N-acetyl-L-cysteine potentiates interleukin-1β induction of nitric oxide synthase: role of p44/42 mitogen-activated protein kinases. Hypertension 35: 914-918, 2000.
11. Jiang B, Brecher P, and Cohen RA. Persistent activation of nuclear factor-κB by interleukin-1β and subsequent inducible NO synthase expression requires extracellular signal-regulated kinase. Arterioscler Thromb Vasc Biol 21: 1915-1920, 2001.
12. Jiang B, Haverty M, and Brecher P. N-acetyl-L-cysteine enhances interleukin-1β-induced nitric oxide synthase expression. Hypertension 34: 574-579, 1999.
13. Jiang B, Xu S, Brecher P, and Cohen RA. Growth factors enhance interleukin-1β-induced persistent activation of nuclear factor-κB in rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 22: 1811-1816, 2002.
14. Jiang B, Xu S, Hou X, Pimentel DR, Brecher P, and Cohen RA. Temporal control of NF-κB activation by ERK differentially regulates interleukin-1β-induced gene expression. J Biol Chem 279: 1323-1329, 2004.
15. Jiang B, Xu S, Hou X, Pimentel DR, and Cohen RA. Angiotensin II differentially regulates interleukin-1β -inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK. J Biol Chem 279: 20363-20368, 2004.
16. Karin M. How NF-κB is activated: the role of the IκB kinase (IKK) complex. Oncogene 18: 6867-6874, 1999.
17. Le Bail O, Schmidt-Ullrich R, and Israel A. Promoter analysis of the gene encoding the IκB-α /MAD3 inhibitor of NF-κB: positive regulation by members of the rel/NF-κB family. EMBO J 12: 5043-5049, 1993.
18. Libby P, Ridker PM, and Maseri A. Inflammation and atherosclerosis. Circulation 105: 1135-1143, 2002.
19. Lindner V and Collins T. Expression of NF-κB and IκB-α by aortic endothelium in an arterial injury model. Am J Pathol 148: 427-438, 1996.
20. Malek S, Chen Y, Huxford T, and Ghosh G. IκBβ, but not IκBα, functions as a classical cytoplasmic inhibitor of NF-κB dimers by masking both NF-κB nuclear localization sequences in resting cells. J Biol Chem 276: 45225-45235, 2001.
21. Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, and Rao A. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278: 860-866, 1997.
22. Phelps CB, Sengchanthalangsy LL, Huxford T, and Ghosh G. Mechanism of IκBα binding to NF-κB dimers. J Biol Chem 275: 29840-29846, 2000.
23. Plutzky J. Inflammatory pathways in atherosclerosis and acute coronary syndromes. Am J Cardiol 88: 10K-15K, 2001.
24. Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, and Rothe M. Identification and characterization of an IκB kinase. Cell 90: 373-383, 1997.
25. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 340: 115-126, 1999.
26. Suyang H, Phillips R, Douglas I, and Ghosh S. Role of unphosphorylated, newly synthesized IκBβ in persistent activation of NF-κB. Mol Cell Biol 16: 5444-5449, 1996.
27. Thompson JE, Phillips RJ, Erdjument-Bromage H, Tempst P, and Ghosh S. IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell 80: 573-582, 1995.
28. Wu C and Ghosh S. Differential phosphorylation of the signal-responsive domain of IκBα and IκBβ by IκB kinases. J Biol Chem 278: 31980-31987, 2003.
29. Yang X, Chen Y, and Gabuzda D. ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-κB. J Biol Chem 274: 27981-27988, 1999.
30. Zandi E, Rothwarf DM, Delhase M, Hayakawa M, and Karin M. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91: 243-252, 1997.