20-Hydroxyeicosatetraenoic acid impairs endothelial insulin signaling by inducing phosphorylation of the insulin receptor substrate-1 at Ser 616

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Li, Xuguang ^a   Zhao, Gang ^b   Ma, Ben ^b   Li, Rui ^b   Hong, Jiang ^a   Liu, Shaowen ^a   Wang, Dao Wen ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE; STRESS ACTIVATED PROTEIN KINASE; 20-HYDROXY-5,8,11,14-EICOSATETRAENOIC ACID; CARDIOVASCULAR AGENT; HYDROXYICOSATETRAENOIC ACID; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; NOS3 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; VASODILATATION; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTA; C57BL MOUSE; CARDIOVASCULAR DISEASES; CELL CULTURE; DRUG EFFECTS; DRUG SCREENING; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN PROCESSING;

ANIMALS; AORTA; CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MAP KINASE SIGNALING SYSTEM; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; SERINE;

EID: 84899760368     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095841     Document Type: Article

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