Inhibition of Ca2+/calmodulin-dependent protein kinase II, RAS-GTPase and 20-hydroxyeicosatetraenoic acid attenuates the development of diabetes-induced vascular dysfunction in the rat carotid artery

Pharmacological Research

Volumn 52, Issue 3, 2005, Pages 252-257

  Benter, Ibrahim F ^a   Yousif, Mariam H M ^a   Canatan, Halit ^a   Akhtar, Saghir ^b  

^a KUWAIT UNIVERSITY   (Kuwait)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

20 HETE; Carotid artery; Cytochrome P450; Diabetes

Indexed keywords

1 AMINOBENZOTRIAZOLE; 20 HYDROXYICOSATETRAENOIC ACID; CARBACHOL; ENDOTHELIN 1; ENZYME INHIBITOR; GUANOSINE TRIPHOSPHATASE; HET 0016; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; N HYDROXY N'(4 BUTYL 2 METHYLPHENYL)FORMAMIDINE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN KINASE (CALCIUM,CALMODULIN) II; RAS PROTEIN; UNCLASSIFIED DRUG; VASOACTIVE AGENT; 1-AMINOBENZOTRIAZOLE; 2 (2 OXO 2 ((3,7,11 TRIMETHYL 2,6,10 DODECATRIENYL)OXY)AMINOETHYL)PHOSPHONIC ACID, (2,2 DIMETHYL 1 OXOPROPOXY)METHYL ESTER SODIUM; 2-(2-OXO-2-((3,7,11-TRIMETHYL-2,6,10-DODECATRIENYL)OXY)AMINOETHYL)PHOSPHONIC ACID, (2,2-DIMETHYL-1-OXOPROPOXY)METHYL ESTER SODIUM; 20 HYDROXY 5,8,11,14 EICOSATETRAENOIC ACID; 20-HYDROXY-5,8,11,14-EICOSATETRAENOIC ACID; AMIDINE; BENZYLAMINE DERIVATIVE; CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN-DEPENDENT PROTEIN KINASE II; HYDROXYICOSATETRAENOIC ACID; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; N HYDROXY N' (4 BUTYL 2 METHYLPHENYL)FORMAMIDINE; N-HYDROXY-N'-(4-BUTYL-2-METHYLPHENYL)FORMAMIDINE; PHOSPHONIC ACID DERIVATIVE; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE INHIBITOR; STREPTOZOCIN; SULFONAMIDE; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; DEPOLARIZATION; DIABETES MELLITUS; DISEASE COURSE; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; VASCULAR DISEASE; VASOCONSTRICTION; VASODILATATION; ANIMAL; CAROTID ARTERY DISEASE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; PATHOPHYSIOLOGY; WISTAR RAT;

AMIDINES; ANIMALS; BENZYLAMINES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CAROTID ARTERIES; CAROTID ARTERY DISEASES; DIABETES MELLITUS, EXPERIMENTAL; HYDROXYEICOSATETRAENOIC ACIDS; MONOMERIC GTP-BINDING PROTEINS; PHOSPHONIC ACIDS; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR; STREPTOZOCIN; SULFONAMIDES; TRIAZOLES; VASCULAR DISEASES; VASOCONSTRICTION; VASODILATION;

EID: 22144470113     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phrs.2005.04.001     Document Type: Article

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