Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion

Journal of Biological Chemistry

Volumn 286, Issue 25, 2011, Pages 21982-21992

  McCluskey, Jane T ^a,c   Hamid, Muhajir ^a,d   Guo Parke, Hong ^a   McClenaghan, Neville H ^a   Gomis, Ramon ^b   Flatt, Peter R ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b HOSPITAL CLÍNIC   (Spain)

^c UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^d QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CELL; BIOCHEMICAL STUDIES; CELL LINES; CHANNEL COMPLEX; DRUG TESTING; ELECTROFUSION; EPITHELIAL CELLS; FUNCTIONAL CHARACTERIZATION; GLUCOKINASE; GLUCOSE UPTAKE; IMMUNOHISTOCHEMISTRY; INSULIN SECRETION; METABOLIC FUNCTION; PANCREATIC BETA CELLS; PROINSULIN; PROOF OF CONCEPT; SECRETORY GRANULES; STABLE CHARACTERISTICS; WESTERN BLOTS;

AMINO ACIDS; BIOGRAPHIES; CELL CULTURE; DRUG PRODUCTS; DRUG THERAPY; GENE EXPRESSION; GLUCOSE; INSULIN; MAMMALS; PEPTIDES; PHOSPHORYLATION; PHYSIOLOGY;

CELLS;

ALANINE; C PEPTIDE; CALCIUM CHANNEL L TYPE; CALCIUM ION; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 1; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; POTASSIUM ION; PROINSULIN; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; SULFONYLUREA RECEPTOR 1;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINE; CELL STRAIN 1.1B4; CELL STRAIN 1.1E7; CELL STRAIN 1.4E7; CONTROLLED STUDY; DIABETES MELLITUS; ELECTROFUSION (CELL); ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; SECRETORY GRANULE;

ADULT; ANIMALS; CALCIUM; CELL FUSION; CELL LINE; CELL PROLIFERATION; CLONE CELLS; DIABETES MELLITUS, EXPERIMENTAL; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN-SECRETING CELLS; INTRACELLULAR SPACE; KATP CHANNELS; MICE; OXIDATION-REDUCTION; PROTEIN TRANSPORT;

MUS;

EID: 79959331354     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.226795     Document Type: Article

References (35)

1. Miyazaki, J., Araki, K., Yamato, E., Ikegami, H., Asano, T., Shibasaki, Y., Oka, Y., and Yamamura, K. (1990) Endocrinology 127, 126-132
2. Hanahan, D. (1985) Nature 315, 115-122
3. Radvanyi, F., Christgau, S., Baekkeskov, S., Jolicoeur, C., and Hanahan, D. (1993) Mol. Cell Biol. 13, 4223-4232
4. Santerre, R. F., Cook, R. A., Crisel, R. M., Sharp, J. D., Schmidt, R. J., Williams, D. C., and Wilson, C. P. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 4339-4343
5. Ashcroft, S. J., Hammonds, P., and Harrison, D. E. (1986) Diabetologia 29, 727-733
6. Chick, W. L., Warren, S., Chute, R. N., Like, A. A., Lauris, V., and Kitchen, K. C. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 628-632
7. McClenaghan, N. H., Barnett, C. R., Ah-Sing, E., Abdel-Wahab, Y. H., O'Harte, F. P., Yoon, T. W., Swanston-Flatt, S. K., and Flatt, P. R. (1996) Diabetes. 45, 1132-1140
8. Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P. A., and Wollheim, C. B. (1992) Endocrinology 130, 167-178
9. Efrat, S., and Fleisher, N. (1996) in Diabetes Mellitus: A Fundamental and Clinical Text (LeRoith, D., Olefsky, J. M., and Taylor, S. I., eds) pp. 438-443, Lippincott-Raven Publishers, Philadelphia
10. Wang, S., Beattie, G. M., Mally, M. I., Cirulli, V., Itkin-Ansari, P., Lopez, A. D., Hayek, A., and Levine, F. (1997) Cell Transplant. 6, 59-67
11. Gueli, N., Toto, A., Palmieri, G., Carmenini, G., and Delpino, A. (1987) J. Exp. Clin. Cancer Res. 6, 281-285
12. Thivolet, C., Chatelain, P., Haftek, M., Durand, A., and Pugeat, M. (1986) C. R. Acad. Sci. III. 303, 381-386
13. Thivolet, C. H., Demidem, A., Haftek, M., Durand, A., and Bertrand, J. (1988) Diabetes 37, 1279-1286
14. Gartner, W., Koc, F., Nabokikh, A., Daneva, T., Niederle, B., Luger, A., and Wagner, L. (2006) Neuroendocrinology 83, 123-130
15. Soldevila, G., Buscema, M., Marini, V., Sutton, R., James, R. F., Bloom, S. R., Robertson, R. P., Mirakian, R., Pujol-Borrell, R., and Bottazzo, G. F. (1991) J. Autoimmun. 4, 381-396
16. Zalzman, M., Anker-Kitai, L., and Efrat, S. (2005) Diabetes 54, 2568-2575
17. MacFarlane, W. M., Chapman, J. C., Shepherd, R. M., Hashmi, M. N., Kamimura, N., Cosgrove, K. E., O'Brien, R. E., Barnes, P. D., Hart, A. W., Docherty, H. M., Lindley, K. J., Aynsley-Green, A., James, R. F., Docherty, K., and Dunne, M. J. (1999) J. Biol. Chem. 274, 34059-34066
18. de la Tour, D., Halvorsen, T., Demeterco, C., Tyrberg, B., Itkin-Ansari, P., Loy, M., Yoo, S. J., Hao, E., Bossie, S., and Levine, F. (2001) Mol. Endocrinol. 15, 476-483
19. Narushima, M., Kobayashi, N., Okitsu, T., Tanaka, Y., Li, S. A., Chen, Y., Miki, A., Tanaka, K., Nakaji, S., Takei, K., Gutierrez, A. S., Rivas-Carrillo, J. D., Navarro-Alvarez, N., Jun, H. S., Westerman, K. A., Noguchi, H., Lakey, J. R., Leboulch, P., Tanaka, N., and Yoon, J. W. (2005) Nat. Biotechnol. 23, 1274-1282
20. Lieber, M., Mazzetta, J., Nelson-Rees, W., Kaplan, M., and Todaro, G. (1975) Int. J. Cancer. 15, 741-747
21. Flatt, P. R., and Bailey, C. J. (1981) Diabetologia 20, 573-577
22. Karnovsky, M. J. (1965) J. Cell Biol. 27, 137-138
23. Lenzen, S., Tiedge, M., and Panten, U. (1986) Biochem. Pharmacol. 35, 2841-2843
24. Jarrett, R. J., and Keen, H. (1966) Lancet 1, 633-635
25. Miguel, J. C., Patterson, S., Abdel-Wahab, Y. H., Mathias, P. C., and Flatt, P. R. (2004) Cell Calcium 36, 43-50
26. Tsang, W. G., Zheng, T., Wang, Y., Tang, J., Rind, H. B., Francki, A., and Bufius, N. (2007) Transplantation 83, 685-693
27. Hellman, B., Gylfe, E., Grapengissar, E., Lund, P. E., and Marcstrom, A. (1992) in Nutrient Regulation of Insulin Secretion (Flatt, P. R., ed) pp. 213-246, Portland Press, London
28. Meglasson, M. D., and Matschinsky, F. M. (1986) Diabetes. Metab. Rev. 2, 163-214
29. Ohneda, M., Johnson, J. H., Lee, Y. H., Nagasawa, Y., and Unger, R. H. (1994) Am. J. Physiol. 267, E9668-E9674
30. Lenzen, S., and Tiedge, M. (1994) Biochem. Soc. Trans. 22, 1-6
31. Kramer, W., Müller, G., and Geisen, K. (1996) Horm. Metab. Res. 28, 464-468
32. Ehses, J. A., Lee, S. S., Pederson, R. A., and McIntosh, C. H. (2001) J. Biol. Chem. 276, 23667-23673
33. Farilla, L., Bulotta, A., Hirshberg, B., Li, Calzi, S., Khoury, N., Noushmehr, H., Bertolotto, C., Di Mario, U., Harlan, D. M., and Perfetti, R. (2003) Endocrinology 144, 5149-5158
34. Burnham, D. B., and Williams, J. A. (1982) J. Biol. Chem. 257, 10523-10528
35. Henquin, J. C., Debuyser, A., Drews, G., and Plant, T. D. (1992) in Nutrient Regulation of Insulin Secretion (Flatt, P. R., ed) pp. 172-192, Portland Press, London