메뉴 건너뛰기




Volumn 77, Issue 9-11, 2014, Pages 516-534

Exposure to the three structurally different PCB congeners (PCB 118, 153, and 126) results in decreased protein expression and altered steroidogenesis in the human adrenocortical carcinoma cell line H295R

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; HYDROCORTISONE; POLYCHLORINATED BIPHENYL; PROTEOME; TESTOSTERONE;

EID: 84899735870     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287394.2014.886985     Document Type: Conference Paper
Times cited : (19)

References (65)
  • 2
    • 0034076120 scopus 로고    scopus 로고
    • Inhibition of rat testicular androgenesis by a polychlorinated biphenyl mixture aroclor 1248
    • Andric, S. A., Kostic, T. S., Stojilkovic, S. S., and Kovacevic, R. Z. 2000. Inhibition of rat testicular androgenesis by a polychlorinated biphenyl mixture aroclor 1248. Biol Reprod 62: 1882-1888.
    • (2000) Biol Reprod , vol.62 , pp. 1882-1888
    • Andric, S.A.1    Kostic, T.S.2    Stojilkovic, S.S.3    Kovacevic, R.Z.4
  • 4
    • 79960296361 scopus 로고    scopus 로고
    • Brain proteome alterations of Atlantic cod (Gadus morhua) exposed to PCB 153
    • Berg, K., Puntervoll, P., Klungsoyr, J., and Goksoyr, A. 2011. Brain proteome alterations of Atlantic cod (Gadus morhua) exposed to PCB 153. Aquat. Toxicol. 105: 206-217.
    • (2011) Aquat. Toxicol. , vol.105 , pp. 206-217
    • Berg, K.1    Puntervoll, P.2    Klungsoyr, J.3    Goksoyr, A.4
  • 5
    • 0025310667 scopus 로고
    • Transport and cellular uptake of polychlorinated biphenyls (PCBs)-II. Changes in vivo in plasma lipoproteins and proteins of pigeons in response to PCBs, and a proposed model for the transport and cellular uptake of PCBs
    • Borlakoglu, J. T., Welch, V. A., Edwards-Webb, J. D., and Dils, R. R. 1990. Transport and cellular uptake of polychlorinated biphenyls (PCBs)-II. Changes in vivo in plasma lipoproteins and proteins of pigeons in response to PCBs, and a proposed model for the transport and cellular uptake of PCBs. Biochem. Pharmacol. 40: 273-281.
    • (1990) Biochem. Pharmacol. , vol.40 , pp. 273-281
    • Borlakoglu, J.T.1    Welch, V.A.2    Edwards-Webb, J.D.3    Dils, R.R.4
  • 6
    • 0017616398 scopus 로고
    • Tissue localization of polychlorinated biphenyls. Chemical structure related to pattern of distribution
    • Brandt, I. 1977. Tissue localization of polychlorinated biphenyls. Chemical structure related to pattern of distribution. Acta Pharmacol. Toxicol. (Copenh.) 40(suppl. 2): 1-108.
    • (1977) Acta Pharmacol. Toxicol. (Copenh.) , vol.40 , Issue.SUPPL. 2 , pp. 1-108
    • Brandt, I.1
  • 8
    • 81055136649 scopus 로고    scopus 로고
    • Cytosol protein regulation in H295R steroidogenesis model induced by the zearalenone metabolites, alpha- and beta-zearalenol
    • Busk, O. L., Frizzell, C., Verhaegen, S., Uhlig, S., Connolly, L., Ropstad, E., and Sorlie, M. 2012. Cytosol protein regulation in H295R steroidogenesis model induced by the zearalenone metabolites, alpha- and beta-zearalenol. Toxicon 59: 17-24.
    • (2012) Toxicon , vol.59 , pp. 17-24
    • Busk, O.L.1    Frizzell, C.2    Verhaegen, S.3    Uhlig, S.4    Connolly, L.5    Ropstad, E.6    Sorlie, M.7
  • 9
    • 82555191420 scopus 로고    scopus 로고
    • Relative quantification of the proteomic changes associated with the mycotoxin zearalenone in the H295R steroidogenesis model
    • Busk, O. L., Ndossi, D., Verhaegen, S., Connolly, L., Eriksen, G., Ropstad, E., and Sorlie, M. 2011. Relative quantification of the proteomic changes associated with the mycotoxin zearalenone in the H295R steroidogenesis model. Toxicon 58: 533-542.
    • (2011) Toxicon , vol.58 , pp. 533-542
    • Busk, O.L.1    Ndossi, D.2    Verhaegen, S.3    Connolly, L.4    Eriksen, G.5    Ropstad, E.6    Sorlie, M.7
  • 11
    • 0034661990 scopus 로고    scopus 로고
    • Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin
    • Chandel, N. S., Trzyna, W. C., McClintock, D. S., and Schumacker, P. T. 2000. Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J. Immunol. 165: 1013-1021.
    • (2000) J. Immunol. , vol.165 , pp. 1013-1021
    • Chandel, N.S.1    Trzyna, W.C.2    McClintock, D.S.3    Schumacker, P.T.4
  • 12
    • 35449005911 scopus 로고    scopus 로고
    • Diabetes in relation to serum levels of polychlorinated biphenyls and chlorinated pesticides in adult Native Americans
    • Codru, N., Schymura, M. J., Negoita, S., Rej, R., and Carpenter, D. O. 2007. Diabetes in relation to serum levels of polychlorinated biphenyls and chlorinated pesticides in adult Native Americans. Environ. Health Perspect. 115: 1442-1447.
    • (2007) Environ. Health Perspect. , vol.115 , pp. 1442-1447
    • Codru, N.1    Schymura, M.J.2    Negoita, S.3    Rej, R.4    Carpenter, D.O.5
  • 13
    • 84860589539 scopus 로고    scopus 로고
    • Blood levels of dioxins, furans, dioxin-like PCBs, and TEQs in general populations: A review, 1989-2010
    • Consonni, D., Sindaco, R., and Bertazzi, P. A. 2012. Blood levels of dioxins, furans, dioxin-like PCBs, and TEQs in general populations: A review, 1989-2010. Environ. Int. 44: 151-162.
    • (2012) Environ. Int. , vol.44 , pp. 151-162
    • Consonni, D.1    Sindaco, R.2    Bertazzi, P.A.3
  • 14
    • 0032859445 scopus 로고    scopus 로고
    • Polymorphic forms of the protein L-isoaspartate (Daspartate) O-methyltransferase involved in the repair of age-damaged proteins
    • DeVry, C. G., and Clarke, S. 1999. Polymorphic forms of the protein L-isoaspartate (Daspartate) O-methyltransferase involved in the repair of age-damaged proteins. J. Hum. Genet. 44(5): 275-288.
    • (1999) J. Hum. Genet. , vol.44 , Issue.5 , pp. 275-288
    • Devry, C.G.1    Clarke, S.2
  • 15
    • 33644779627 scopus 로고    scopus 로고
    • The relationship between noncoplanar PCB-induced immunotoxicity and hepatic CYP1A induction in a fish model
    • Duffy, J. E., and Zelikoff, J. T. 2006. The relationship between noncoplanar PCB-induced immunotoxicity and hepatic CYP1A induction in a fish model. J. Immunotoxicol. 3: 39-47.
    • (2006) J. Immunotoxicol. , vol.3 , pp. 39-47
    • Duffy, J.E.1    Zelikoff, J.T.2
  • 16
    • 70449564488 scopus 로고    scopus 로고
    • Insulin-degrading enzyme: Structure-function relationship and its possible roles in health and disease
    • Fernandez-Gamba, A., Leal, M. C., Morelli, L., and Castano, E. M. 2009. Insulin-degrading enzyme: Structure-function relationship and its possible roles in health and disease. Curr. Pharm. Design 15: 3644-3655.
    • (2009) Curr. Pharm. Design , vol.15 , pp. 3644-3655
    • Fernandez-Gamba, A.1    Leal, M.C.2    Morelli, L.3    Castano, E.M.4
  • 17
    • 1842484141 scopus 로고    scopus 로고
    • Dioxin/polychlorinated biphenyl body burden, diabetes and endometriosis: Findings in a population-based study in Belgium
    • Fierens, S., Mairesse, H., Heilier, J. F., De Burbure, C., Focant, J. F., Eppe, G., De Pauw, E., and Bernard, A. 2003. Dioxin/polychlorinated biphenyl body burden, diabetes and endometriosis: Findings in a population-based study in Belgium. Biomarkers 8: 529-534.
    • (2003) Biomarkers , vol.8 , pp. 529-534
    • Fierens, S.1    Mairesse, H.2    Heilier, J.F.3    De Burbure, C.4    Focant, J.F.5    Eppe, G.6    De Pauw, E.7    Bernard, A.8
  • 19
    • 70450216122 scopus 로고    scopus 로고
    • Mechanisms involved in the neurotoxic effects of environmental toxicants such as polychlorinated biphenyls and brominated flame retardants
    • Fonnum, F., and Mariussen, E. 2009. Mechanisms involved in the neurotoxic effects of environmental toxicants such as polychlorinated biphenyls and brominated flame retardants. J. Neurochem. 111: 1327-1347.
    • (2009) J. Neurochem. , vol.111 , pp. 1327-1347
    • Fonnum, F.1    Mariussen, E.2
  • 24
    • 53349103037 scopus 로고    scopus 로고
    • Action of defined mixtures of PCBs, p,p′-DDT and its metabolite p,p′-DDE, on co-culture of porcine theca and granulosa cells: Steroid secretion, cell proliferation and apoptosis
    • Gregoraszczuk, E. L., Ptak, A., Karniewska, M., and Ropstad, E. 2008. Action of defined mixtures of PCBs, p,p′-DDT and its metabolite p,p′-DDE, on co-culture of porcine theca and granulosa cells: steroid secretion, cell proliferation and apoptosis. Reprod. Toxicol. 26: 170-174.
    • (2008) Reprod. Toxicol. , vol.26 , pp. 170-174
    • Gregoraszczuk, E.L.1    Ptak, A.2    Karniewska, M.3    Ropstad, E.4
  • 27
    • 33750351770 scopus 로고    scopus 로고
    • Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: Hormone production
    • Hecker, M., Newsted, J. L., Murphy, M. B., Higley, E. B., Jones, P. D., Wu, R., and Giesy, J. P. 2006. Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production. Toxicol. Appl. Pharmacol. 217: 114-124.
    • (2006) Toxicol. Appl. Pharmacol. , vol.217 , pp. 114-124
    • Hecker, M.1    Newsted, J.L.2    Murphy, M.B.3    Higley, E.B.4    Jones, P.D.5    Wu, R.6    Giesy, J.P.7
  • 28
    • 0034667405 scopus 로고    scopus 로고
    • Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency
    • Hestermann, E. V., Stegeman, J. J., and Hahn, M. E. 2000. Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency. Toxicol. Appl. Pharmacol. 168: 160-172.
    • (2000) Toxicol. Appl. Pharmacol. , vol.168 , pp. 160-172
    • Hestermann, E.V.1    Stegeman, J.J.2    Hahn, M.E.3
  • 29
    • 4444240722 scopus 로고    scopus 로고
    • Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR
    • Hilscherova, K., Jones, P. D., Gracia, T., Newsted, J. L., Zhang, X., Sanderson, J. T., Yu, R. M., Wu, R. S., and Giesy, J. P. 2004. Assessment of the effects of chemicals on the expression of ten steroidogenic genes in the H295R cell line using real-time PCR. Toxicol. Sci. 81: 78-89.
    • (2004) Toxicol. Sci. , vol.81 , pp. 78-89
    • Hilscherova, K.1    Jones, P.D.2    Gracia, T.3    Newsted, J.L.4    Zhang, X.5    Sanderson, J.T.6    Yu, R.M.7    Wu, R.S.8    Giesy, J.P.9
  • 31
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity
    • Karin, M., and Ben-Neriah, Y. 2000. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol. 18: 621-663.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 32
    • 77954024415 scopus 로고    scopus 로고
    • Three structurally different polychlorinated biphenyl congeners (Pcb 118, 153, and 126) affect hormone production and gene expression in the human H295R in vitro model
    • Kraugerud, M., Zimmer, K. E., Dahl, E., Berg, V., Olsaker, I., Farstad, W., Ropstad, E., and Verhaegen, S. 2010. Three structurally different polychlorinated biphenyl congeners (Pcb 118, 153, and 126) affect hormone production and gene expression in the human H295R in vitro model. J. Toxicol. Environ. Health A 73: 1122-1132.
    • (2010) J. Toxicol. Environ. Health A , vol.73 , pp. 1122-1132
    • Kraugerud, M.1    Zimmer, K.E.2    Dahl, E.3    Berg, V.4    Olsaker, I.5    Farstad, W.6    Ropstad, E.7    Verhaegen, S.8
  • 37
    • 34547735466 scopus 로고    scopus 로고
    • Polychlorinated biphenyl exposure and CYP19 gene regulation in testicular and adrenocortical cell lines
    • Li, L. A. 2007. Polychlorinated biphenyl exposure and CYP19 gene regulation in testicular and adrenocortical cell lines. Toxicol. In Vitro 21: 1087-1094.
    • (2007) Toxicol. In Vitro , vol.21 , pp. 1087-1094
    • Li, L.A.1
  • 38
    • 0030874533 scopus 로고    scopus 로고
    • The human mitochondrial elongation factor tu (EF-Tu) gene: CDNA sequence, genomic localization, genomic structure, and identification of a pseudogene
    • Ling, M., Merante, F., Chen, H. S., Duff, C., Duncan, A. M., and Robinson, B. H. 1997. The human mitochondrial elongation factor tu (EF-Tu) gene: cDNA sequence, genomic localization, genomic structure, and identification of a pseudogene. Gene 197: 325-336.
    • (1997) Gene , vol.197 , pp. 325-336
    • Ling, M.1    Merante, F.2    Chen, H.S.3    Duff, C.4    Duncan, A.M.5    Robinson, B.H.6
  • 39
    • 0035374632 scopus 로고    scopus 로고
    • Polychlorinated biphenyl serum levels in pregnant subjects with diabetes
    • Longnecker, M. P., Klebanoff, M. A., Brock, J. W., and Zhou, H. 2001. Polychlorinated biphenyl serum levels in pregnant subjects with diabetes. Diabetes Care 24: 1099-1101.
    • (2001) Diabetes Care , vol.24 , pp. 1099-1101
    • Longnecker, M.P.1    Klebanoff, M.A.2    Brock, J.W.3    Zhou, H.4
  • 40
    • 0042665648 scopus 로고    scopus 로고
    • Effect of a single dose of polychlorinated biphenyls on hepatic cell proliferation and the DNA binding activity of NF-kappaB and AP-1 in rats
    • Lu, Z., Tharappel, J. C., Lee, E. Y., Robertson, L. W., Spear, B. T., and Glauert, H. P. 2003. Effect of a single dose of polychlorinated biphenyls on hepatic cell proliferation and the DNA binding activity of NF-kappaB and AP-1 in rats. Mol. Carcinogen. 37: 171-180.
    • (2003) Mol. Carcinogen. , vol.37 , pp. 171-180
    • Lu, Z.1    Tharappel, J.C.2    Lee, E.Y.3    Robertson, L.W.4    Spear, B.T.5    Glauert, H.P.6
  • 41
    • 77955398981 scopus 로고    scopus 로고
    • Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells
    • Lucas, T. F., Royer, C., Siu, E. R., Lazari, M. F., and Porto, C. S. 2010. Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells. Biol. Reprod. 83: 307-317.
    • (2010) Biol. Reprod. , vol.83 , pp. 307-317
    • Lucas, T.F.1    Royer, C.2    Siu, E.R.3    Lazari, M.F.4    Porto, C.S.5
  • 42
    • 77953259958 scopus 로고    scopus 로고
    • Nartural mixtures of persistent organic pollutants increase weight gain, advance puberty and induce gene expression associated withy steroid hormones and obesity in female zebrafish
    • Lyche, J. L., Nourizadeh-Lillabadi, R., Almaas, C., Stavik, B., Berg, V., Skaare, J. U., Alestrom, P. and Ropstad, E. 2010. Nartural mixtures of persistent organic pollutants increase weight gain, advance puberty and induce gene expression associated withy steroid hormones and obesity in female zebrafish. J. Toxicol. Environ. Health A 73: 1032-1057.
    • (2010) J. Toxicol. Environ. Health A , vol.73 , pp. 1032-1057
    • Lyche, J.L.1    Nourizadeh-Lillabadi, R.2    Almaas, C.3    Stavik, B.4    Berg, V.5    Skaare, J.U.6    Alestrom, P.7    Ropstad, E.8
  • 43
    • 47249140327 scopus 로고    scopus 로고
    • Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells
    • Murugesan, P., Muthusamy, T., Balasubramanian, K., and Arunakaran, J. 2008. Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells. Reprod. Toxicol. 25: 447-454.
    • (2008) Reprod. Toxicol. , vol.25 , pp. 447-454
    • Murugesan, P.1    Muthusamy, T.2    Balasubramanian, K.3    Arunakaran, J.4
  • 47
    • 12944269065 scopus 로고
    • Rapid identification of proteins by peptidemass fingerprinting
    • Pappin, D. J., Hojrup, P., and Bleasby, A. J. 1993. Rapid identification of proteins by peptidemass fingerprinting. Curr. Biol. 3: 327-332.
    • (1993) Curr. Biol. , vol.3 , pp. 327-332
    • Pappin, D.J.1    Hojrup, P.2    Bleasby, A.J.3
  • 52
    • 0028235721 scopus 로고
    • Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment
    • Safe, S. H. 1994. Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit. Rev. Toxicol. 24: 87-149.
    • (1994) Crit. Rev. Toxicol. , vol.24 , pp. 87-149
    • Safe, S.H.1
  • 53
    • 10144257865 scopus 로고    scopus 로고
    • Functional interdependence between septin and actin cytoskeleton
    • Schmidt, K., and Nichols, B. J. 2004. Functional interdependence between septin and actin cytoskeleton. BMC Cell Biol. 5: 43.
    • (2004) BMC Cell Biol. , vol.5 , pp. 43
    • Schmidt, K.1    Nichols, B.J.2
  • 54
    • 0030444287 scopus 로고    scopus 로고
    • Epidemiological and laboratory evidence of PCB-induced neurotoxicity
    • Seegal, R. F. 1996. Epidemiological and laboratory evidence of PCB-induced neurotoxicity. Crit. Rev. Toxicol. 26: 709-737.
    • (1996) Crit. Rev. Toxicol. , vol.26 , pp. 709-737
    • Seegal, R.F.1
  • 56
    • 0030728770 scopus 로고    scopus 로고
    • Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit
    • Spataro, V., Toda, T., Craig, R., Seeger, M., Dubiel, W., Harris, A. L., and Norbury, C. 1997. Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit. J. Biol. Chem. 272: 30470-30475.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30470-30475
    • Spataro, V.1    Toda, T.2    Craig, R.3    Seeger, M.4    Dubiel, W.5    Harris, A.L.6    Norbury, C.7
  • 57
    • 0027450247 scopus 로고
    • Regulation of steroidogenesis in NCIH295 cells: A cellular model of the human fetal adrenal
    • Staels, B., Hum, D. W., and Miller, W. L. 1993. Regulation of steroidogenesis in NCIH295 cells: a cellular model of the human fetal adrenal. Mol. Endocrinol. 7: 423-433.
    • (1993) Mol. Endocrinol. , vol.7 , pp. 423-433
    • Staels, B.1    Hum, D.W.2    Miller, W.L.3
  • 59
    • 33344456597 scopus 로고    scopus 로고
    • New modes of action for endocrine-disrupting chemicals
    • Tabb, M. M., and Blumberg, B. 2006. New modes of action for endocrine-disrupting chemicals. Mol. Endocrinol. 20: 475-482.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 475-482
    • Tabb, M.M.1    Blumberg, B.2
  • 61
    • 0034283198 scopus 로고    scopus 로고
    • Activation of respiratory burst in human granulocytes by polychlorinated biphenyls: A structure-activity study
    • Voie, O. A., Tysklind, M., Andersson, P. L., and Fonnum, F. 2000. Activation of respiratory burst in human granulocytes by polychlorinated biphenyls: A structure-activity study. Toxicol Appl Pharmacol 167: 118-124.
    • (2000) Toxicol Appl Pharmacol , vol.167 , pp. 118-124
    • Voie, O.A.1    Tysklind, M.2    Andersson, P.L.3    Fonnum, F.4
  • 62
    • 33645526843 scopus 로고    scopus 로고
    • Aromatic hydrocarbon receptor (AhR) in the porcine theca and granulosa cells: Effect of TCDD, PCB 126 and PCB 153 on the expression of AhR
    • Wojtowicz, A., Tomanek, M., Augustowska, K., and Gregoraszczuk, E. L. 2005a. Aromatic hydrocarbon receptor (AhR) in the porcine theca and granulosa cells: Effect of TCDD, PCB 126 and PCB 153 on the expression of AhR. Endocr. Regul. 39: 109-118.
    • (2005) Endocr. Regul. , vol.39 , pp. 109-118
    • Wojtowicz, A.1    Tomanek, M.2    Augustowska, K.3    Gregoraszczuk, E.L.4
  • 63
    • 16244387067 scopus 로고    scopus 로고
    • Polychlorinated biphenyls (PCB 153 and PCB 126) action on conversion of 20-hydroxylated cholesterol to progesterone, androstenedione to testosterone, and testosterone to estradiol 17beta
    • Wojtowicz, A. K., Goch, M., and Gregoraszczuk, E. L. 2005b. Polychlorinated biphenyls (PCB 153 and PCB 126) action on conversion of 20-hydroxylated cholesterol to progesterone, androstenedione to testosterone, and testosterone to estradiol 17beta. Exp. Clin. Endocrinol. Diabetes 113: 464-470.
    • (2005) Exp. Clin. Endocrinol. Diabetes , vol.113 , pp. 464-470
    • Wojtowicz, A.K.1    Goch, M.2    Gregoraszczuk, E.L.3
  • 64
    • 84877592204 scopus 로고    scopus 로고
    • PFOS and PCB 153 have direct adverse effects on neonatal testis modeled using a coculture of primary gonocyte and sertoli cells
    • Zhang, J., Liang, J., Zhu, H., Li, C., and Wu, Q. 2013. PFOS and PCB 153 have direct adverse effects on neonatal testis modeled using a coculture of primary gonocyte and sertoli cells. Environ. Toxicol. 28: 322-331.
    • (2013) Environ. Toxicol. , vol.28 , pp. 322-331
    • Zhang, J.1    Liang, J.2    Zhu, H.3    Li, C.4    Wu, Q.5
  • 65
    • 60749095664 scopus 로고    scopus 로고
    • Altered stressinduced cortisol levels in goats exposed to polychlorinated biphenyls (PCB 126 and PCB 153) during fetal and postnatal development
    • Zimmer, K. E., Gutleb, A. C., Lyche, J. L., Dahl, E., Oskam, I. C., Krogenaes, A., Skaare, J. U., and Ropstad, E. 2009. Altered stressinduced cortisol levels in goats exposed to polychlorinated biphenyls (PCB 126 and PCB 153) during fetal and postnatal development. J. Toxicol. Environ. Health A 72: 164-172.
    • (2009) J. Toxicol. Environ. Health A , vol.72 , pp. 164-172
    • Zimmer, K.E.1    Gutleb, A.C.2    Lyche, J.L.3    Dahl, E.4    Oskam, I.C.5    Krogenaes, A.6    Skaare, J.U.7    Ropstad, E.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.