Skin grafting for venous leg ulcers

Cochrane Database of Systematic Reviews

Volumn 2013, Issue 1, 2013, Pages

  Jones, June E ^a   Nelson, E Andrea ^b   Al Hity, Aws ^a  

^a School of Healthcare ^*  (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO;

AUTOGRAFT; CLINICAL OUTCOME; COMPARATIVE STUDY; FREEZE DRYING; FROZEN SECTION; HUMAN; KERATINOCYTE; LEG ULCER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SKIN ALLOGRAFT; SKIN AUTOGRAFT; SKIN BLOOD FLOW; SKIN STRUCTURE; SKIN TRANSPLANTATION; SURGICAL TECHNIQUE; SYSTEMATIC REVIEW; TISSUE ENGINEERING; TREATMENT RESPONSE; WOUND CARE; WOUND CLOSURE; WOUND HEALING; XENOGRAFT; ADULT; AUTOTRANSPLANTATION; META ANALYSIS; OCCLUSIVE DRESSING;

ADULT; HUMANS; LEG ULCER; OCCLUSIVE DRESSINGS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SKIN TRANSPLANTATION; TRANSPLANTATION, AUTOLOGOUS;

MLCS; MLOWN;

EID: 84874812963     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD001737.pub4     Document Type: Review

References (92)

1. Brown-Etris M, Shields DK, Galluzzi KE, Steinberg JS, Shalen AB, Barnes HR, et al.Preliminary clinical outcomes on the use of composite cultured skin for the healing of venous ulcers. 13th Annual Symposium on Advanced Wound Care and 10th Annual Medical Research Forum on Wound Repair; 2000, 1-4 April; Dallas, Texas. 2000:D5.
2. Burdge J, Cope F, Abbruzzese B, Wille J. Long-term healing of venous stasis ulcers treated with serum-free cultured epidermal autografts. Eleventh Annual Meeting and Educational Symposuim Wound Healing Society; 2001, 16-18 May; Albuquerque, New Mexico. 2001:146.
3. Burdge J, Swanson N, Pittelkow M, Cope F, Abbruzzese B, Schaefer S, et al.Successful treatment of venous stasis leg ulcers with a cultured autologous epidermal graft. Wound Healing Society Educational Symposium; 2000, 4-6 June; Toronto, Canada. 2000:10.
4. Duhra P, Blight A, Mountford E, Cheshire I, Withers A, Ilchyshyn A. A randomized controlled trial of cultured keratinocyte allografts for chronic venous ulcers. Journal of Dermatological Treatment 1992;3:189-91.
5. Atillasoy E. The safety and efficacy of Graftskin (APLIGRAF) in the treatment of venous leg ulcers: a multicenter, randomized, controlled clinical trial. Wounds - A Compendium of Clinical Research and Practice 2000;12(Suppl A):20A-6A.
6. Falanga V, Margolis D, Alvarez O, Auletta M, Maggiacomo F, Altman M, et al.Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Archives of Dermatology 1998;134:293-300.
7. Falanga V, Sabolinski M. A bilayered living skin construct (APLIGRAF) accelerates complete closure of hard-to-heal venous ulcers. Wound Repair and Regeneration 1999;7:201-7.
8. Sabolinski M, Rovee D, Parenteau N, Mulder G, Jensen J. The efficacy and safety of graftskin for the treatment of chronic venous ulcers. 5th Annual Meeting of the Wound Healing Society and the Regeneration Forum; 1994, 27-30 April; Minneapolis USA. 1995:78.
9. Sabolinski ML, Alvarez O, Auletta M, Mulder G, Parenteau NL. Cultured skin as a 'smart material' for healing wounds: experience in venous ulcers. Biomaterials 1996;17:311-20.
10. Schonfeld WH, Villa KF, Fastenau JM, Mazonson PD, Falanga V. An economic assessment of APLIGRAF (Graftskin) for the treatment of hard-to-heal venous leg ulcers. Wound Repair and Regeneration 2000;8:251-7.
11. Goedkoop R, Juliet R, You PHK, Daroczy J, De Roos K, Lijnen R, et al.Wound stimulation by growth-arrested human keratinocytes and fibroblasts: HP802-247, a new-generation allogenic tissue engineering product. Dermatology 2010;220:114-20.
12. Jankunas V, Bagdonas R, Samsanavicius D, Rimdeika R. An analysis of the effectiveness of skin grafting to treat chronic venous leg ulcers. Wounds: A Compendium of Clinical Research and Practice 2007;19(5):128-37.
13. Harding KG, Brassard A, Dolynchuck K, Leaper D, Poskitt K, Sibbald RG. A pilot study to determine the effect of human dermal replacement in treating hard-to-heal venous leg ulcers. Proceedings of the 13th Annual Symposium on Advanced Wound Care & 10th Annual Medical Research Forum on Wound Repair. USA: HMP Communications, LLC. 2000:C68.
14. Krishnamoorthy L, Harding KG, Griffiths D, Moore K, Leaper D, Poskitt K, et al.The clinical and histological effects of Dermagraft® in the healing of chronic venous leg ulcers. Phlebology 2003;18(1):12-22.
15. Lindgren C, Marcusson J, Toftgard R. Treatment of venous leg ulcers with cryopreserved cultured allogeneic keratinocytes: a prospective open controlled study. British Journal of Dermatology 1998;139:271-5.
16. Liu JY, Hafner J, Dragieva G, Seifert B, Burg G. Autologous cultured keratinocytes on porcine gelatin microbeads effectively heal chronic venous leg ulcers. Wound Repair and Regeneration 2004;12(2):148-56.
17. Navratilova Z. Cryopreserved and lyophilized cultured epidermal allografts in the treatment of leg ulcers. 20th World Congress of Dermatology. 2002.
18. Navratilova Z, Slonkova V, Semradova V, Adler J. Cryopreserved and lyophilized cultured epidermal allografts in the treatment of leg ulcers: a pilot study. Journal of the European Academy of Dermatology & Venereology 2004;18(2):173-9.
19. Omar AA, Mavor AI, Jones AM, Homer-Vanniasinkam S. Treatment of venous leg ulcers with Dermagraft. European Journal of Vascular and Endovascular Surgery 2004;27(6):666-72.
20. Paquet P, Quatresooz P, Braham C, Piérard GE. Tapping into the influence of keratinocyte allografts and biocenosis on healing of chronic leg ulcers: split-ulcer controlled pilot study. Dermatologic Surgery 2005;31(4):431-5.
21. Poskitt K, James A, Lloyd-Davies E, Walton J, McCollum C. Pinch skin grafting or porcine dermis in venous ulcers: a randomised clinical trial. British Medical Journal 1987;294:674-6.
22. Salomon D. Epidex: a new treatment for recalcitrant chronic leg ulcers (abstract). 20th World Congress of Dermatology; 2002, 1-5 July; Paris. 2002.
23. Tausche A, Skaria M, Bohlen L, Liebold K, Hafner J, Friedlein H, et al.An autologous epidermal equivalent tissue-engineered from follicular outer root sheath keratinocytes is as effective as split-thickness skin autograft in recalcitrant vascular leg ulcers. Wound Repair and Regeneration 2003;11(4):248-52.
24. Teepe R, Roseeuw D, Hermans J, Koebrugge E, Altena T, Coninck A, et al.Randomized trial comparing cryopreserved cultured epidermal allografts with hydrocolloid dressings in healing chronic venous ulcers. Journal of the American Academy of Dermatology 1993;29(6):982-8.
25. Warburg F, Danielsen L, Madsen S, Raaschou H, Munkvad S, Jensen R, et al.Vein surgery with or without skin grafting versus conservative treatment for leg ulcers. Acta Dermatologica Venereologica (Stockholm) 1994;74(4):307-9.
26. Ahnlide I, Bjellerup M. Efficacy of pinch grafting in leg ulcers of different aetiologies. Acta Dermatologica Venereologica (Stockholm) 1997;77:144-5.
27. Altman MI. Treatment of venous ulcers with human skin equivalent [letter]. Journal of the American Podiatric Medical Association 1997;87(8):392-4.
28. Andersen MN, Stephens JG. A controlled study of surgical treatment and pathogenesis of stasis ulcers. Annals of Surgery 1959;150:57-62.
29. Beele H, Naeyaert JM, Goeteyn M, De Mil M, Kint A. Repeated cultured epidermal allografts in the treatment of chronic leg ulcers of various origins. Dermatologica 1991;183(1):31-5.
30. Berretty PJ, Neumann HA, de Limpens AM, Cormane RH. Treatment of ulcers on legs from venous hypertension by split-thickness skin grafts. Journal of Dermatology, Surgery and Oncology 1979;5(12):966-70.
31. Boyce ST, Glatter R, Kitzmiller WJ. Case studies: treatment of chronic wounds with cultured skin substitutes. Ostomy/Wound Management 1995;41(2):26-8, 30, 32 passim.
32. Calonge H, Ruszczak Z, Stadler R. Human cultured epidermal auto- and allografts for wound healing. New method for in vitro epidermis reconstruction. Proceedings of the 1st Joint Meeting of the Wound Healing Society and the European Tissue Repair Society. 22-25 August 1993. Amsterdam, The Netherlands:85.
33. Carpentier P. Venous ulcer: the final stage in chronic venous disease - managing it in 2009 (Pierre Fabre Symposium). Phlebolymphology 2010;17(1):28-9.
34. Carver N, Leigh IM. Keratinocyte grafts and skin equivalents. International Journal of Dermatology 1991;30(8):540-51.
35. Chang DW, Sancheez LA, Veith FJ, Wain RA, Okhi T, Suggs WD. Can a tissue-engineered skin graft improve healing of lower extremity foot wounds after revascularization?. Annals of Vascular Surgery 2000;14(1):44-9.
36. Christiansen J, Ek L, Tegner E. Pinch grafting of leg ulcers. A retrospective study of 412 treated ulcers in 146 patients. Acta Dermatologica Venereologica 1997;77(6):471-3.
37. Clancy JM, Shehade SA, Blight AE, Young KE, Levick PL. Treatment of leg ulcers with cultured epithelial grafts. Journal of the American Academy of Dermatology 1988;18(6):1356-7.
38. Coney M, Donatien PH, Beylot C, Geniaux M, Maleville J, Bezian JH, et al.Treatment of leg ulcers with an allogenic cultured-keratinocyte-collagen dressing. Clinical and Experimental Dermatology 1990;15:410-4.
39. Dahlstrom KK, Weis Fogh US, Medgyesi S, Rostgaard J, Sorensen H. The use of autologous fibrin adhesive in skin transplantation. Plastic and Reconstructive Surgery 1992;89(5):968-72.
40. Demling RH, Niezgoda JA, Haraway GD, Mostow EN. Small intestinal submucosa wound matrix and full-thickness venous ulcers: preliminary results. Wounds: A Compendium of Clinical Research and Practice 2004;16(1):18-22.
41. Fahey C. Experience with a new human skin equivalent for healing venous leg ulcers. Journal of Vascular Nursing 1998;16(1):11-5.
42. Farah R, Davis MDP. Venous leg ulceration: a treatment update. Current Treatment Options in Cardiovascular Medicine 2010;12(2):101-16.
43. Halter G, Kapfer X, Liewald F, Bischoff M. Vacuum-sealed mesh graft transplantation in chronic cutaneous ulcers of the lower leg. VASA 2003;32:155-8.
44. Harris IR, Bottomley W, Wood EJ, Cunliffe WJ. Use of autografts for the treatment of leg ulcers in elderly patients. Clinical Experimental Dermatology 1993;18(5):417-20.
45. Harrison PV. Split-skin grafting of varicose leg ulcers - a survey and the importance of assessment of risk factors in predicting outcome from the procedure. Clinical Experimental Dermatology 1988;13(1):4-6.
46. Henderson HP, Marples RR, Richardson JF. Comparison of topical antibacterial agents in the preparation of varicose ulcers for skin grafting. Journal of Hospital Infection 1980;1(2):141-7.
47. Kirsner RS, Eaglstein WH, Kerdel FA. Split-thickness skin grafting for lower extremity ulcerations. Dermatologic Surgery 1997;23:85-91.
48. Leigh IM, Purkis PE. Culture grafted leg ulcers. Clinical Experimental Dermatology 1986;11(6):650-2.
49. Limova M, Mauro T. Treatment of leg ulcers with cultured epithelial autografts: clinical study and case reports. Ostomy/Wound Management 1995;41(8):48-50, 52, 54-60.
50. Mahajan R, Mosley JG. Use of a semipermeable polyamide dressing over skin grafts to venous leg ulcers. British Journal of Surgery 1995;82(10):1359-60.
51. Marcusson JA, Lindgren C, Berghard A, Toftgard R. Allogeneic cultured keratinocytes in the treatment of leg ulcers: a pilot study. Acta Dermatologica Venereologica 1992;72(1):61-4.
52. Mekkes JR, Westerhof W. Excising necrotic venous ulcers, by using absorbing polysaccharide pads [Debridement van necrotische veneuze ulcera met behulp van absorberende polysaccharide pads]. Therapie, Geneesmiddel en Onderzoek 1992;17(9):253-7.
53. Millard LG, Roberts MM, Gatecliffe M. Chronic leg ulcers treated by the pinch graft method. British Journal of Dermatology 1977;97(3):289-95.
54. Mol M, Nanninga B, Eendenburg J, Westerhof W, Mekkes J, Ginkel C. Grafting of venous leg ulcers. Journal of the American Academy of Dermatology 1991;24(1):77-82.
55. Mostow E, Haraway G, Dalsing M, Hodde J, King D. Effectiveness of an extracellular matrix graft (OASIS Wound Matrix) in the treatment of chronic leg ulcers: a randomized clinical trial. Journal of Vascular Surgery 2005;41(5):837-43.
56. Muhart M, McFalls S, Kirsner R, Kerdel F, Eaglstein WH. Bioengineered skin. Lancet 1998;350:1142.
57. O'Donnell Jr TF, Lau J. A systematic review of randomized controlled trials of wound dressings for chronic venous ulcers. Journal of Vascular Surgery 2006;44(5):1118-25.
58. Oien R, Hansen B, Hakansson A. Pinch grafting of leg ulcers in primary care. Acta Dermatologica Venereologica (Stockholm) 1998;78:438-9.
59. Ortega Z, Hunziker T, Lauchi S, Mayer DO, Huber C, Baumann C, et al.Epidex Swiss field trial. 2004-2008. Dermatology 2010;221(4):365-72.
60. Phillips TJ, Kehinde O, Green H, Gilchrest BA. Treatment of skin ulcers with cultured epidermal allografts. Journal of the American Academy of Dermatology 1989;21(2 Pt 1):191-9.
61. Phillips TJ. Cultured epidermal allografts - a temporary or permanent solution?. Transplantation 1991;51(5):937-41.
62. Pojda Z, Struzyna J. New method for treatment of the non-healing wounds with the split thickness skin grafts preincubated with granulocyte-macrophage colony-stimulating factor (GM-CSF). 4th Annual Meeting of the European Tissue Repair Society; 1994, 25-28 August; Oxford, England. 1994:201.
63. Puonti H, Asko Seljavaara S. Excision and skin grafting of leg ulcers. Annales Chirurgiae Gynaecologiae 1998;87(3):219-23.
64. Ruffieux P, Hommel L, Saurat JH. Long-term assessment of chronic leg ulcer treatment by autologous skin grafts. Dermatology 1997;195(1):77-80.
65. Shehade S, Clancy J, Blight A, Young K, Levick P. Cultured epithelial allografting of leg ulcers. Journal of Dermatological Treatment 1989;1/2:79-81.
66. Skene AI, Smith JM, Dore CJ, Charlett A, Lewis JD. Venous leg ulcers: a prognostic index to predict time to healing. BMJ 1992;305(6862):1119-21.
67. Slonkova V, Navratilova Z, Semradova V, Adler J. Cultures epidermal keratinocytes in the treatment of leg ulcers. Part 11. Comparison of the effect of cryopreserved and lyophilized allografts. Cesko-Slovenska Dermatologie 2002;77(6):239-44.
68. Steele K. Pinch grafting for chronic venous leg ulcers in general practice. Journal of the Royal College of General Practitioners 1985;35(281):574-5.
69. Townsend J. Skin grafting leg ulcers. Lancet 1970;1(7636):39.
70. Trent JF, Kirsner RS. Tissue engineered skin: Apligraf, a bi-layered living skin equivalent. International Journal of Clinical Practice 1998;52(6):408-13.
71. Van den Hoogenband HM. Treatment of leg ulcers with split-thickness skin grafts. Journal of Dermatology, Surgery and Oncology 1984;10(8):605-8.
72. Villeneuve P, Hafner J, Prenosil JE, Elsner P, Burg G. A novel culturing and grafting system for the treatment of leg ulcers. British Journal of Dermatology 1998;138(5):849-51.
73. Vin F, Teot L, Meaume S. The healing properties of Promogran in venous leg ulcers. Journal of Wound Care 2002;11(9):335-41.
74. Ward DJ, Bennett JP, Burgos H, Fabre J. The healing of chronic venous leg ulcers with prepared human amnion. British Journal of Plastic Surgery 1989;42(4):463-7.
75. Wille JJ, Burdge JJ, Pitttelkow MR. Rapid healing of chronic venous stasis leg ulcers treated by the application of a novel serum-free cultured autologous epidermis. Wound Repair and Regeneration 2011;19(4):464-74.
76. Organogenesis. Apligraf: add life after healing. http://www.apligraf.com/. Organogenesis Inc., 2010.
77. Baker SR, Stacey MC, Singh G, Hoskin SE, Thompson PJ. Aetiology of chronic leg ulcers. European Journal of Vascular Surgery 1992;6:245-51.
78. Barrandon Y, Green G. Three clonal type keratinocytes with different capacities for multiplication. Proceedings of the National Academy of Science (USA) 1987;84:2302-6.
79. Barwell JR, Davies CE, Deacon J, Harvey K, Minor J, Sassano A, et al.Comparison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): randomised controlled trial. Lancet 2004;363:1854-9.
80. Bosanquet N. Costs of venous ulcers - from maintenance therapy to investment programs. Phlebology 1992;7:44-6.
81. Callam MJ, Ruckley CV, Harper DR, Dale JJ. Chronic ulceration of the leg: extent of the problem and the provision of care. British Medical Journal 1985;290(6485):1855-6.
82. Callam MJ. Chronic leg ulceration: the Lothian and Forth Valley Leg Ulcer Study. University of Dundee: ChM Thesis, 1989.
83. Charles H. The impact of leg ulcers on patients' quality of life. Professional Nurse 1995;10:571-4.
84. Compton CC, Tong Y, Trookman N, Zhao H, Roy D, Press W. Transforming growth factor and gene expression in cultured human keratinocytes is unaffected by cellular ageing. Archives of Dermatology 1995;131:683-90.
85. Enoch S, Shaaban H, Dunn KW. Informed consent should be obtained from patients to use products (skin substitutes) and dressings containing biological material. Journal of Medical Ethics 2005;31:2-6.
86. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327(7414):557-60.
87. Higgins JPT, Altman DG, on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group (Editors). Chapter 8. Assessing risk of bias in included studies. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
88. Lees TA, Lambert D. Prevalence of lower limb ulceration in an urban health district. British Journal of Surgery 1992;79:1032-4.
89. Lefebvre C, Manheimer E, Glanville J, on behalf of the Cochrane Information Retrieval Methods Group. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
90. Margolis DJ, Allen-Taylor L, Hoffstad O, Berlin JA. The accuracy of venous leg ulcer prognostic models in a wound care system. Wound Repair and Regeneration 2004;12(2):163-8.
91. Phillips T, Kehinde O, Green H, Gilchrest BA. Treatment of skin ulcers with cultured epidermal allografts. Journal of the American Academy of Dermatology 1989;21(2 Pt 1):191-9.
92. Scottish Intercollegiate Guidelines Network (SIGN). Search filters. http://www.sign.ac.uk/methodology/filters.html#random 2011.