Targeted NGF siRNA delivery attenuates sympathetic nerve sprouting and deteriorates cardiac dysfunction in rats with myocardial infarction

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Hu, Hesheng ^a   Xuan, Yongli ^a   Wang, Ye ^a   Xue, Mei ^a   Suo, Fei ^a   Li, Xiaolu ^a   Cheng, Wenjuan ^a   Li, Xinran ^a   Yin, Jie ^a   Liu, Ju ^a   Yan, Suhua ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH ASSOCIATED PROTEIN; LENTIVIRUS VECTOR; MESSENGER RNA; NERVE GROWTH FACTOR; NEUROMODULIN; SMALL INTERFERING RNA; TYROSINE 3 MONOOXYGENASE; VASCULOTROPIN; CD31 ANTIGEN; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAPILLARY DENSITY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; GENE SILENCING; HEART DISEASE; HEART HEMODYNAMICS; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FAILURE; HISTOPATHOLOGY; IN VIVO STUDY; LENTIVIRINAE; MALE; NERVE SPROUTING; NONHUMAN; PERICARDIOTOMY; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYMPATHETIC NERVE; THORACOTOMY; VIRAL GENE DELIVERY SYSTEM; ADRENERGIC SYSTEM; ANIMAL; COMPLICATION; ECHOGRAPHY; GENETIC TRANSDUCTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART LEFT VENTRICLE FUNCTION; HEMODYNAMICS; METABOLISM; MICROVASCULATURE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PATHOPHYSIOLOGY; WISTAR RAT;

ANIMALS; ANTIGENS, CD31; GAP-43 PROTEIN; GENE SILENCING; HEMODYNAMICS; LENTIVIRUS; MALE; MICROVESSELS; MYOCARDIAL INFARCTION; NEOVASCULARIZATION, PATHOLOGIC; NERVE GROWTH FACTOR; RATS, WISTAR; RNA, SMALL INTERFERING; SYMPATHETIC NERVOUS SYSTEM; TRANSDUCTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84899672665     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095106     Document Type: Article

References (33)

1. Hausenloy DJ, Yellon DM (2013) Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest 123: 92-100.
2. Thiene G, Basso C (2010) Myocardial infarction: a paradigm of success in modern medicine. Cardiovasc Pathol 19: 1-5.
3. Henkel DM, Witt BJ, Gersh BJ, Jacobsen SJ, Weston SA, et al. (2006) Ventricular arrhythmias after acute myocardial infarction: a 20-year community study. Am Heart J 151: 806-812.
4. Minicucci MF, Azevedo PS, Polegato BF, Paiva SA, Zornoff LA (2011) Heart failure after myocardial infarction: clinical implications and treatment. Clin Cardiol 34: 410-414.
5. Gajarsa JJ, Kloner RA (2011) Left ventricular remodeling in the post-infarction heart: a review of cellular, molecular mechanisms, and therapeutic modalities. Heart Fail Rev 16: 13-21.
6. Govoni S, Pascale A, Amadio M, Calvillo L, D'Elia E, et al. (2011) NGF and heart: Is there a role in heart disease? Pharmacol Res 63: 266-277.
7. Lockhart ST, Turrigiano GG, Birren SJ (1997) Nerve growth factor modulates synaptic transmission between sympathetic neurons and cardiac myocytes. J Neurosci 17: 9573-9582. (Pubitemid 28006401)
8. Snider WD (1994) Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77: 627-638.
9. Zhou S, Chen LS, Miyauchi Y, Miyauchi M, Kar S, et al. (2004) Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs. Circ Res 95: 76-83. (Pubitemid 38931838)
10. Cao J-M, Chen LS, KenKnight BH, Ohara T, Lee M-H, et al. (2000) Nerve sprouting and sudden cardiac death. Circ Res 86: 816-821. (Pubitemid 30217832)
11. Heath B, Xia J, Dong E, An R, Brooks A, et al. (1998) Overexpression of nerve growth factor in the heart alters ion channel activity and b-adrenergic signalling in an adult transgenic mouse. J Physiol 512: 779-791. (Pubitemid 28505308)
12. Swissa M, Zhou S, Gonzalez-Gomez I, Chang C-M, Lai AC, et al. (2004) Long-term subthreshold electrical stimulation of the left stellate ganglion and a canine model of sudden cardiac death. J Am Coll Cardiol 43: 858-864. (Pubitemid 38296489)
13. Wang Y, Liu J, Suo F, Hu HS, Xue M, et al. (2013) Metoprolol-mediated amelioration of sympathetic nerve sprouting after myocardial infarction. Cardiology 126: 50-58.
14. El-Helou V, Proulx C, Gosselin H, Clement R, Mimee A, et al. (2008) Dexamethasone treatment of post-MI rats attenuates sympathetic innervation of the infarct region. J Appl Physiol (1985) 104: 150-156.
15. Kang CS, Chen CC, Lin CC, Chang NC, Lee TM (2009) Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts. Am J Physiol Heart Circ Physiol 296: H1949-1959.
16. Xin P, Pan Y, Zhu W, Huang S, Wei M, et al. (2010) Favorable effects of resveratrol on sympathetic neural remodeling in rats following myocardial infarction. Eur J Pharmacol 649: 293-300.
17. Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, et al. (2004) Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. J Clin Invest 113: 876-884. (Pubitemid 38544146)
18. Ieda M, Kanazawa H, Ieda Y, Kimura K, Matsumura K, et al. (2006) Nerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts. Circulation 114: 2351-2363. (Pubitemid 44847452)
19. Caporali A, Sala-Newby GB, Meloni M, Graiani G, Pani E, et al. (2008) Identification of the prosurvival activity of nerve growth factor on cardiac myocytes. Cell Death Differ 15: 299-311.
20. Meloni M, Caporali A, Graiani G, Lagrasta C, Katare R, et al. (2010) Nerve growth factor promotes cardiac repair following myocardial infarction. Circ Res 106: 1275-1284.
21. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, et al. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. nature 411: 494-498.
22. Barde I, Salmon P, Trono D (2010) Production and titration of lentiviral vectors. Curr Protoc Neurosci: 4.21. 21-24.21. 23.
23. Katz MG, Swain JD, Tomasulo CE, Sumaroka M, Fargnoli A, et al. (2011) Current strategies for myocardial gene delivery. J Mol Cell Cardiol 50: 766-776.
24. Pacher P, Nagayama T, Mukhopadhyay P, Batkai S, Kass DA (2008) Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats. Nat Protoc 3: 1422-1434.
25. Christov C, Chretien F, Abou-Khalil R, Bassez G, Vallet G, et al. (2007) Muscle satellite cells and endothelial cells: close neighbors and privileged partners. Mol Biol Cell 18: 1397-1409. (Pubitemid 46626634)
26. Yan S-H, Hu H-S, Wang X-L, Xing Q-C, Wang Q, et al. (2007) Effects of prolonged metoprolol treatment on neural remodeling and inducible ventricular arrhythmias after myocardial infarction in rabbits. Int J Cardiol 117: 317-322. (Pubitemid 46507622)
27. Fiedler J, Jazbutyte V, Kirchmaier BC, Gupta SK, Lorenzen J, et al. (2011) MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 124: 720-730.
28. Huang W, Zhang D, Millard RW, Wang T, Zhao T, et al. (2010) Gene manipulated peritoneal cell patch repairs infarcted myocardium. J Mol Cell Cardiol 48: 702-712.
29. Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative CT method. Nature protocols 3: 1101-1108. (Pubitemid 351818697)
30. Benabdellah K, Cobo M, Munoz P, Toscano MG, Martin F (2011) Development of an all-in-one lentiviral vector system based on the original TetR for the easy generation of Tet-ON cell lines. PLoS One 6: e23734.
31. Barandon L, Couffinhal T, Dufourcq P, Ezan J, Costet P, et al. (2004) Frizzled A, a novel angiogenic factor: promises for cardiac repair. Eur J Cardiothorac Surg 25: 76-83. (Pubitemid 38019062)
32. Haider HK, Akbar SA, Ashraf M (2009) Angiomyogenesis for myocardial repair. Antioxidants & redox signaling 11: 1929-1944.
33. Emanueli C, Salis MB, Pinna A, Graiani G, Manni L, et al. (2002) Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs. Circulation 106: 2257-2262. (Pubitemid 35222222)