Overexpression of nerve growth factor in the heart alters ion channel activity and β-adrenergic signalling in an adult transgenic mouse

Journal of Physiology

Volumn 512, Issue 3, 1998, Pages 779-791

  Heath, B M ^a,b   Xia, J ^a   Dong, E ^a,c   An, R H ^a   Brooks, A ^a   Liang, C S ^a,c   Federoff, H J ^a,c   Kass, R S ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; ADENYLATE CYCLASE; BETA ADRENERGIC RECEPTOR; CALCIUM ION; CYCLIC AMP; FORSKOLIN; GUANYLYLIMIDODIPHOSPHATE; ION CHANNEL; ISOPRENALINE; NERVE GROWTH FACTOR; POTASSIUM CHANNEL; POTASSIUM ION; RECEPTOR SUBTYPE; TETRYLAMMONIUM;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART VENTRICLE HYPERTROPHY; MOUSE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DENSITY; TRANSGENE;

ACTION POTENTIALS; ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ANIMALS; CELL DIVISION; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; GUANYLYL IMIDODIPHOSPHATE; ION CHANNELS; ISOPROTERENOL; MICE; MICE, TRANSGENIC; MYOCARDIUM; NERVE GROWTH FACTORS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RECEPTORS, ADRENERGIC, BETA; SIGNAL TRANSDUCTION;

EID: 0032211498     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.779bd.x     Document Type: Article

References (45)

1. ARONSON, R. S. (1980). Characteristics of action potentials of hypertrophied myocardium from rats with renal hypertension. Circulation Research 47, 443-454.
2. + channel. Journal of Biological Chemistry 268, 24283-24289.
3. BARRY, D. M. & NERBONNE, J. M. (1996). Myocardial potassium channels: electrophysiological and molecular diversity. Annual Review of Physiology 58, 363-394.
4. BENITAH, J. P., GOMEZ, A. M., BAILLY, P., DA PONTE, J. P., BERSON, G. X., DELGADO, C. & LORENTE, P. (1993). Heterogeneity of the early outward current in ventricular cells isolated from normal and hypertrophied rat hearts. Journal of Physiology 469, 111-138.
5. BENNDORF, K. & NILIUS, B. (1988). Properties of an early outward current in single cells of the mouse ventricle. General Physiology and Biophysics 7, 449-466.
6. + currents in isolated human ventricular myocytes from patients with terminal heart failure. Circulation Research 73, 379-385.
7. BOURON, A., POTREAU, D. & RAYMOND, G. (1992). The L-type calcium current in single hypertrophied cardiomyocytes isolated from the right ventricle of ferret heart. Cardiovascular Research 26, 662-670.
8. BRISTOW, M. R., GINSBURG, R., MINOBE, W., CUBICCIOTTI, R. S. X., SAGEMAN, W. S., LURIE, K., BILLINGHAM, M. E., HARRISON, D. C. & STINSON, E. B. (1982). Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. New England Journal of Medicine 307, 205-211.
9. BRISTOW, M. R., MINOBE, W., RASMUSSEN, R., HERSHBERGER, R. E. X. & HOFFMAN, B. B. (1988). Alpha-1 adrenergic receptors in the nonfailing and failing human heart. Journal of Pharmacology and Experimental Therapeutics 247, 1039-1045.
10. CAMPBELL, D., RASMUSSON, R., CORNER, M. & STRAUSS, H. (1997). The cardiac calcium-independent outward potassium current: kinetics, molecular properties and role in ventricular repolarization. In Cardiac Electrophysiology: From Cell to Bedside, 2nd edn, ed. ZIPES, D. & JALIFFE, J., pp. 83-96. W. B. Saunders and Co., Philadelphia.
11. CERBAI, E., BARBIERI, M., LI, Q. & MUGELLI, A. (1994). Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages. Cardiovascular Research 28, 1180-1187.
12. o-induced electrical heterogeneity and extra-systolic activity in isolated canine ventricular epicardium. Circulation 89, 1839-1850.
13. + channel in ventricular muscle. A molecular correlate for the transient outward current. Circulation Research 79, 659-668.
14. 2-adrenoceptors. European Journal of Pharmacology 130, 137-139.
15. ERTL, R., JAHNEL, U., NAWRATH, H., CARMELIET, E. & VEREECKE, J. (1991). Differential electrophysiologic and inotropic effects of phenylephrine in atrial and ventricular heart muscle preparations from rats. Naunyn-Schmiedeberg's Archives of Pharmacology 344, 574-581.
16. FAN, T. H., LIANG, C. S., KAWASHIMA, S. & BANERJEE, S. P. (1987). Alterations in cardiac beta-adrenoceptor responsiveness and adenylate cyclase system by congestive heart failure in dogs. European Journal of Pharmacology 140, 123-132.
17. FEDIDA, D., SHIMONI, Y. & GILES, W. R. (1990). Alpha-adrenergic modulation of the transient outward current in rabbit atrial myocytes. Journal of Physiology 423, 257-277.
18. + current in cultured adult human atrial myocytes. Circulation Research 80, 572-579.
19. + currents in adult mouse atrium and ventricle. Biophysical Journal 74, A207.
20. + current modulates repolarization and excitation-contraction coupling in adult mouse ventricle. Journal of Physiology 504, 557-563.
21. FRANCIS, G. S., COHN, J. N., JOHNSON, G., RECTOR, T. S., GOLDMAN, S. & SIMON, A. (1993). Plasma norepinephrine, plasma renin activity, and congestive heart failure. Relations to survival and the effects of therapy in V-HeFT II. The V-HeFT VA cooperative studies group. Circulation 87, VI 40-48.
22. HART, G. (1994). Cellular electrophysiology in cardiac hypertrophy and failure. Cardiovascular Research 28, 933-946.
23. HASSANKHANI, A., STEINHELPER, M. E., SOONPAA, M. H., KATZ, E. B. X., TAYLOR, D. A., ANDRADE-ROZENTAL, A., FACTOR, S. M., STEINBERG, J. J., FIELD, L. J. X. & FEDEROFF, H. J. (1995). Over-expression of NGP within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells. Developmental Biology 169, 309-321.
24. KÄÄB, S., NUSS, H. B., CHIAMVIMONVAT, N., O'ROURKE, B., PAK, P. H. X., KASS, D. A., MARBAN, E. & TOMASELLI, G. F. (1996). Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circulation Research 78, 262-273.
25. KEUNG, E. C. (1989). Calcium current is increased in isolated adult myocytes from hypertrophied rat myocardium. Circulation Research 64, 753-763.
26. KLEIMAN, R. B. & HOUSER, S. R. (1988). Calcium currents in normal and hypertrophied isolated feline ventricular myocytes. American Journal of Physiology 255, H1434-1442.
27. KOTTKAMP, H., BUDDE, T., LAMP, B., HAVERKAMP, W., BORGGREFE, M. X. & BREITHARDT, G. (1994). Clinical significance and management of ventricular arrhythmias in heart failure. European Heart Journal 15, suppl. D, 155-163.
28. LEE, J. K., KODAMA, I., HONJO, H., ANNO, I., KAMIUA, K. & TOYAMA, J. (1997). State-dependent changes in membrane currents in rats with monocrotaline-induced right ventricular hypertrophy. American Journal of Physiology 272, H2833-2842.
29. MCPHERSON, G. A. (1985). Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. Journal of Pharmacological Methods 14, 213-228.
30. MATSUBARA, H., SUZUKI, J. & INADA, M. (1993). Shaker-related potassium channel, Kv1.4, mRNA regulation in cultured rat heart myocytes and differential expression of Kv1.4 and Kv1.5 genes in myocardial development and hypertrophy. Journal of Clinical Investigation 92, 1659-1666.
31. NORDIN, C., SIRI, F. & ARONSON, R. S. (1989). Electrophysiologic characteristics of single myocytes isolated from hypertrophied guinea-pig hearts. Journal of Molecular and Cellular Cardiology 21, 729-739.
32. NUSS, H. B. & HOUSER, S. R. (1991). Voltage dependence of contraction and calcium current in severely hypertrophied feline ventricular myocytes. Journal of Molecular and Cellular Cardiology 23, 717-726.
33. POTREAU, D., GOMEZ, J. P. & FARES, N. (1995). Depressed transient outward current in single hypertrophied cardiomyocytes isolated from the right ventricle of ferret heart. Cardiovascular Research 30, 440-448.
34. POWELL, T., TERRAR, D. A. & TWIST, V. W. (1980). Electrical properties of individual cells isolated from adult rat ventricular myocardium. Journal of Physiology 302, 131-153.
35. ROSSNER, K. L. (1991). Calcium current in congestive heart failure of hamster cardiomyopathy. American Journal of Physiology 260, H1179-1186.
36. RYDER, K. O., BRYANT, S. M. & HART, G. (1993). Membrane current changes in left ventricular myocytes isolated from guinea pigs after abdominal aortic coarctation. Cardiovascular Research 27, 1278-1287.
37. SCAMPS, F., MAYOUX, E., CHARLEMAGNE, D. & VASSORT, G. (1985). Calcium current in single cells isolated from normal and hypertrophied rat heart. Effects of beta-adrenergic stimulation. Circulation Research 67, 199-208.
38. SCHWARTZ, P. J., VANOLI, E., ZAZA, A. & ZUANETTI, G. (1985). The effect of antiarrhythmic drugs on life-threatening arrhythmias induced by the interaction between acute myocardial ischemia and sympathetic hyperactivity. American Heart Journal 109, 937-948.
39. + channel subunit mRNAs in ventricles of renovascular hypertensive rats. Circulation Research 81, 533-539.
40. TEN EICK, R. E. & BASSET, A. L. (1997). Cardiac hypertrophy and altered cellular electrical activity of the myocardium: possible electrophysiological basis for myocardial contractility changes. In Physiology and Pathophysiology of the Heart, ed. SPERELAKIS, N., pp. 521-542. Martinus Nihoff, The Netherlands.
41. TOMITA, F., BASSETT, A. L., MYERBURG, R. J. & KIMURA, S. (1994). Diminished transient outward currents in rat hypertrophied ventricular myocytes. Circulation Research 75, 296-303.
42. + current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circulation Research 80, 772-781.
43. VATNER, D. E., VATNER, S. R, FUJII, A. M. & HOMEY, C. J. (1985). Loss of high affinity cardiac β-adrenergic receptors in dogs withheart failure. Journal of Clinical Investigation 76, 2259-2264.
44. + current similar to Kv1.5 cloned channel currents. Circulation Research 73, 1061-1076.
45. YEOLA, S. W. & SNYDERS, D. J. (1997). Electrophysiological and pharmacological correspondence between Kv4.2 current and rat cardiac transient outward current. Cardiovascular Research 33, 540-547.