Metoprolol-mediated amelioration of sympathetic nerve sprouting after myocardial infarction

Cardiology (Switzerland)

Volumn 126, Issue 1, 2013, Pages 50-58

  Wang, Ye ^a   Liu, Ju ^b   Suo, Fei ^a   Hu, He Sheng ^c   Xue, Mei ^c   Cheng, Wen Juan ^c   Xuan, Yong Li ^a   Yan, Su Hua ^c  

^a SHANDONG UNIVERSITY   (China)

^b Laboratory of Microvascular Medicine   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

Inflammation; Metoprolol; Myocardial infarction; Nuclear factor B; Sympathetic nerve

Indexed keywords

ALPRENOLOL; I KAPPA B; INTERLEUKIN 1BETA; MESSENGER RNA; METOPROLOL TARTRATE; NERVE GROWTH FACTOR; SODIUM CHLORIDE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENSITY; DNA BINDING; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; HEART ARRHYTHMIA; HEART INFARCTION; HEART INFARCTION SIZE; HEART NERVE; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; MALE; NERVE SPROUTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RABBIT; REAL TIME POLYMERASE CHAIN REACTION; SYMPATHETIC INNERVATION; SYMPATHETIC NERVE; WESTERN BLOTTING; EVENING DOSAGE; GENE EXPRESSION; HEART INNERVATION; HEART VENTRICLE ENDDIASTOLIC PRESSURE; MORNING DOSAGE; NERVE REGENERATION; NEW ZEALAND WHITE (RABBIT); PROTEIN BLOOD LEVEL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; SYMPATHETIC NERVE CELL; SYSTOLIC BLOOD PRESSURE; UPREGULATION;

ANIMALS; CORONARY VESSELS; HEART; I-KAPPA B PROTEINS; INTERLEUKIN-1BETA; LIGATION; MALE; METOPROLOL; MYOCARDIAL INFARCTION; NERVE GROWTH FACTOR; NF-KAPPA B; RABBITS; RNA, MESSENGER; SYMPATHETIC NERVOUS SYSTEM; SYMPATHOLYTICS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84880184147     PISSN: 00086312     EISSN: 14219751     Source Type: Journal    
DOI: 10.1159/000351074     Document Type: Article

References (38)

1. Cao JM, Fishbein MC, Han JB, Lai WW, Lai AC, Wu TJ, Czer L, Wolf PL, Denton TA, Shintaku IP, Chen PS, Chen LS: Relationship between regional cardiac hyperinnervation and ventricular arrhythmia. Circulation 2000; 101: 1960-1969.
2. Cao JM, Chen LS, KenKnight BH, Ohara T, Lee MH, Tsai J, Lai WW, Karagueuzian HS, Wolf PL, Fishbein MC, Chen PS: Nerve sprouting and sudden cardiac death. Circ Res 2000; 86: 816-821.
3. Zipes DP, Rubart M: Neural modulation of cardiac arrhythmias and sudden cardiac death. Heart Rhythm 2006; 3: 108-113.
4. Wang Y, Xuan YL, Hu HS, Li XL, Xue M, Cheng WJ, Suo F, Yan SH: Risk of ventricular arrhythmias after myocardial infarction with diabetes associated with sympathetic neural remodeling in rabbits. Cardiology 2012; 121: 1-9.
5. Vaseghi M, Shivkumar K: The role of the autonomic nervous system in sudden cardiac death. Prog Cardiovasc Dis 2008; 50: 404-419.
6. Benowitz LI, Popovich PG: Inflammation and axon regeneration. Curr Opin Neurol 2011; 24: 577-583.
7. Golz G, Uhlmann L, Ludecke D, Markgraf N, Nitsch R, Hendrix S: The cytokine/neurotrophin axis in peripheral axon outgrowth. Eur J Neurosci 2006; 24: 2721-2730.
8. Almarestani L, Longo G, Ribeiro-da-Silva A: Autonomic fiber sprouting in the skin in chronic inflammation. Mol Pain 2008; 4: 56.
9. Tsai MS, Chung SD, Liang JT, Ko YH, Hsu WM, Lai HS, Chang KC: Enhanced expression of cardiac nerve growth factor and nerve sprouting markers in rats following gastric perforation: the association with cardiac sympathovagal balance. Shock 2010; 33: 170- 178.
10. Hasan W, Jama A, Donohue T, Wernli G, Onyszchuk G, Al-Hafez B, Bilgen M, Smith PG: Sympathetic hyperinnervation and inflammatory cell NGF synthesis following myocardial infarction in rats. Brain Res 2006; 1124: 142-154.
11. Yan SH, Hu HS, Wang XL, Xing QC, Wang Q, Shi CW, Cheng WJ, Xue M: Effects of prolonged metoprolol treatment on neural remodeling and inducible ventricular arrhythmias after myocardial infarction in rabbits. Int J Cardiol 2007; 117: 317-322.
12. Jiang H, Lu Z, Yu Y, Zhao D, Jian X, Yang B, Huang C: Effects of metoprolol on sympathetic remodeling and electrical remodeling at infarcted border zone after myocardial infarction in rabbits. Cardiology 2007; 108: 176- 182.
13. Prabhu SD, Chandrasekar B, Murray DR, Freeman GL: β-Adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling. Circulation 2000; 101: 2103-2109.
14. Lu Y, Li L, Zhao X, Huang W, Wen W: Beta blocker metoprolol protects against contractile dysfunction in rats after coronary microembolization by regulating expression of myocardial inflammatory cytokines. Life Sci 2011; 88: 1009-1015.
15. Li Y, Shi J, Yang BF, Liu L, Han CL, Li WM, Dong DL, Pan ZW, Liu GZ, Geng JQ, Sheng L, Tan XY, Sun DH, Gong ZH, Gong YT: Ketamine- induced ventricular structural, sympathetic and electrophysiological remodelling: pathological consequences and protective effects of metoprolol. Br J Pharmacol 2012; 165: 1748-1756.
16. Barnes PJ: Nuclear factor-κB. Int J Biochem Cell Biol 1997; 29: 867-870.
17. Van der Heiden K, Cuhlmann S, Luong LA, Zakkar M, Evans PC: Role of nuclear factor κB in cardiovascular health and disease. Clin Sci (Lond) 2010; 118: 593-605.
18. Lu L, Chen SS, Zhang JQ, Ramires FJ, Sun Y: Activation of nuclear factor-κB and its proinflammatory mediator cascade in the infarcted rat heart. Biochem Biophys Res Commun 2004; 321: 879-885.
19. Trescher K, Bernecker O, Fellner B, Gyongyosi M, Schafer R, Aharinejad S, DeMartin R, Wolner E, Podesser BK: Inflammation and postinfarct remodeling: overexpression of IκB prevents ventricular dilation via increasing TIMP levels. Cardiovasc Res 2006; 69: 746-754.
20. Fujita M, Morimoto Y, Ishihara M, Shimizu M, Takase B, Maehara T, Kikuchi M: A new rabbit model of myocardial infarction without endotracheal intubation. J Surg Res 2004; 116: 124-128.
21. Zhou S, Chen LS, Miyauchi Y, Miyauchi M, Kar S, Kangavari S, Fishbein MC, Sharifi B, Chen PS: Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs. Circ Res 2004; 95: 76-83.
22. Pfeffer MA, Pfeffer JM, Fishbein MC, Fletcher PJ, Spadaro J, Kloner RA, Braunwald E: Myocardial infarct size and ventricular function in rats. Circ Res 1979; 44: 503-512.
23. Pfeffer MA, Braunwald E: Ventricular remodeling after myocardial infarction: experimental observations and clinical implications. Circulation 1990; 81: 1161-1172.
24. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 -ΔΔ C T method. Methods 2001; 25: 402-408.
25. Chen PS, Chen LS, Cao JM, Sharifi B, Karagueuzian HS, Fishbein MC: Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death. Cardiovasc Res 2001; 50: 409-416.
26. El-Helou V, Proulx C, Gosselin H, Clement R, Mimee A, Villeneuve L, Calderone A: Dexamethasone treatment of post-MI rats attenuates sympathetic innervation of the infarct region. J Appl Physiol 2008; 104: 150-156.
27. Kimura K, Ieda M, Fukuda K: Development, maturation, and transdifferentiation of cardiac sympathetic nerves. Circ Res 2012; 110: 325-336.
28. Blasing H, Hendrix S, Paus R: Pro-inflammatory cytokines upregulate the skin immunoreactivity for NGF, NT-3, NT-4 and their receptor, p75NTR in vivo: a preliminary report. Arch Dermatol Res 2005; 296: 580-584.
29. Wernli G, Hasan W, Bhattacherjee A, van Rooijen N, Smith PG: Macrophage depletion suppresses sympathetic hyperinnervation following myocardial infarction. Basic Res Cardiol 2009; 104: 681-693.
30. Rudiger A: Beta-block the septic heart. Crit Care Med 2010; 38:S608-S612.
31. Ackland GL, Yao ST, Rudiger A, Dyson A, Stidwill R, Poputnikov D, Singer M, Gourine AV: Cardioprotection, attenuated systemic inflammation, and survival benefit of β1- adrenoceptor blockade in severe sepsis in rats. Crit Care Med 2010; 38: 388-394.
32. Liang C, Xiaonan L, Xiaojun C, Changjiang L, Xinsheng X, Guihua J, Xiaobo H, Yanen Z, Runyi S, Huixia L, Yun Z, Mei Z: Effect of metoprolol on vulnerable plaque in rabbits by changing shear stress around plaque and reducing inflammation. Eur J Pharmacol 2009; 613: 79-85.
33. Hall G, Hasday JD, Rogers TB: Regulating the regulator: Nf-κB signaling in heart. J Mol Cell Cardiol 2006; 41: 580-591.
34. Hall G, Singh IS, Hester L, Hasday JD, Rogers TB: Inhibitor-κB kinase-β regulates LPS-induced TNF-α production in cardiac myocytes through modulation of NF-κB p65 subunit phosphorylation. Am J Physiol Heart Circ Physiol 2005; 289:H2103-H2111.
35. Hjalmarson A: Cardioprotection with β- adrenoceptor blockers: does lipophilicity matter? Basic Res Cardiol 2000; 95(suppl 1):I41-I45.
36. Cardinal R, Rousseau G, Bouchard C, Vermeulen M, Latour JG, Page PL: Myocardial electrical alteration in canine preparations with combined chronic rapid pacing and progressive coronary artery occlusion. Am J Physiol 2004; 286:H1496-H1506.
37. Dominguez-Rodriguez A, Blanco-Palacios G, Abreu-Gonzalez P: Increased heart rate and atherosclerosis: potential implications of ivabradine therapy. World J Cardiol 2011; 3: 101-104.
38. Ghanem FA, Movahed A: Inflammation in high blood pressure: a clinician perspective. J Am Soc Hypertens 2007; 1: 113-119.