Synthesis and biological evaluation of cinnamido linked benzophenone hybrids as tubulin polymerization inhibitors and apoptosis inducing agents

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 10, 2014, Pages 2309-2314

  Kamal, Ahmed ^a   Reddy, Ch Ratna ^a   Vishnuvardhan, M V P S ^a   Mahesh, R ^a   Lakshma Nayak, V ^a   Prabhakar, S ^a   Reddy, C Suresh ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b SRI VENKATESWARA UNIVERSITY   (India)

Author keywords

Apoptosis; Caspase 3; FACS analysis; Hoechst staining; Tubulin polymerization

Indexed keywords

ANTINEOPLASTIC AGENT; BENZOPHENONE DERIVATIVE; CINNAMIC ACID DERIVATIVE; TUBULIN MODULATOR;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DNA FRAGMENTATION ASSAY; DRUG SYNTHESIS; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; G2 PHASE CELL CYCLE CHECKPOINT; GRIGNARD REACTION; HELA CELL LINE; HUMAN; HUMAN CELL; M PHASE CELL CYCLE CHECKPOINT; MALE; MELANOMA; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; PROSTATE CANCER; TUBULIN POLYMERIZATION ASSAY; APOPTOSIS; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

APOPTOSIS; BENZOPHENONES; CELL LINE, TUMOR; CINNAMATES; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

EID: 84899658971     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.076     Document Type: Article

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