Stereocontrolled synthesis of syn-β-hydroxy-α-amino acids by direct aldolization of pseudoephenamine glycinamide

Angewandte Chemie - International Edition

Volumn 53, Issue 18, 2014, Pages 4642-4647

  Seiple, Ian B ^a   Mercer, Jaron A M ^a   Sussman, Robin J ^a   Zhang, Ziyang ^a   Myers, Andrew G ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

aldol reaction; amino acids; asymmetric synthesis; chiral auxiliaries; synthetic methods

Indexed keywords

ALDEHYDES; CONDENSATION REACTIONS; HYDROLYSIS; KETONES; LITHIUM; STEREOCHEMISTRY;

ALDOL REACTIONS; AMINO ACID DERIVATIVES; ASYMMETRIC SYNTHESIS; CHIRAL AUXILIARIES; CHIRAL BUILDING BLOCKS; LITHIUM HEXAMETHYLDISILAZIDE; STEREOCONTROLLED SYNTHESIS; SYNTHETIC METHODS;

AMINO ACIDS;

ALDEHYDE; AMINO ACID; AMPHETAMINE DERIVATIVE; GLYCINAMIDE; GLYCINE; KETONE; LITHIUM CHLORIDE; LITHIUM DERIVATIVE; LITHIUM HEXAMETHYLDISILAZIDE; PSEUDOEPHENAMINE; SILANE DERIVATIVE;

ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; CHEMISTRY; HYDROLYSIS; STEREOISOMERISM; SYNTHESIS;

ALDEHYDES; AMINO ACIDS; AMPHETAMINES; GLYCINE; HYDROLYSIS; KETONES; LITHIUM CHLORIDE; LITHIUM COMPOUNDS; MOLECULAR STRUCTURE; SILANES; STEREOISOMERISM;

EID: 84899656982     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201400928     Document Type: Article

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