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Racemic 3-aminobutanoic acid is commercially available. Racemic 3-amino-5-methylbutanoic acid was obtained according to: Lazar, L.; Martinek, T.; Bernath, G.; Fulop, F. Synth. Commun. 1998, 28, 219. Racemic 3-amino-3-phenylpropanoic acid was obtained according to: Rodionow, W. M.; Postovskaja, E. A. J. Am. Chem. Soc. 1929, 51, 841.
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Racemic 3-aminobutanoic acid is commercially available. Racemic 3-amino-5-methylbutanoic acid was obtained according to: Lazar, L.; Martinek, T.; Bernath, G.; Fulop, F. Synth. Commun. 1998, 28, 219. Racemic 3-amino-3-phenylpropanoic acid was obtained according to: Rodionow, W. M.; Postovskaja, E. A. J. Am. Chem. Soc. 1929, 51, 841.
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Although these compounds have been used in the racemic form, it is well-known that β-amino acids can be obtained in the enantiomerically pure form by kinetic resolution of the corresponding phenylacetylamides by reaction with enzyme PGA, which selectively hydrolyzes amides of α- and β-amino acids of the L series. See: (a) Rossi, D.; Lucente, G.; Romeo, A. Experientia 1977, 33, 1557.
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85088081972
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10 (12) All new compounds have been fully characterized.
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40
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0043133783
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note
-
As the reaction is totally stereoselective, only the results regarding the trans aziridines 2a-c are reported.
-
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41
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0001009177
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42
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0042632867
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note
-
As the reaction is totally stereoselective, only the results regarding the trans aziridines 2a-c are reported.
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-
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