Zero-mode waveguides for single-molecule analysis at high concentrations

Science

Volumn 299, Issue 5607, 2003, Pages 682-686

  Levene, H J ^a   Korlach, J ^a,b   Turner, S W ^a,c   Foquet, M ^a   Craighead, H G ^a   Webb, W W ^a  

^a Department of Materials Science and Engineering   (United States)

^b Department of Population Medicine and Diagnostic Sciences   (United States)

^c Nanofluidics Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MOLECULAR DYNAMICS;

TEMPORAL RESOLUTION;

WAVEGUIDES;

DNA POLYMERASE; LIGAND;

BIOLOGY; DNA;

ARTICLE; BIOTECHNOLOGY; CONCENTRATION RESPONSE; DYNAMICS; ENZYME ACTIVITY; FILM; PRIORITY JOURNAL; WAVEFORM;

BIOCHEMISTRY; COMPUTER SIMULATION; COUMARINS; DEOXYCYTOSINE NUCLEOTIDES; DIFFUSION; DNA; DNA-DIRECTED DNA POLYMERASE; ENZYMES, IMMOBILIZED; FINITE ELEMENT ANALYSIS; FLUORESCENCE; FLUORESCENT DYES; LIGANDS; LIGHT; NANOTECHNOLOGY; OPTICS; SPECTROMETRY, FLUORESCENCE;

EID: 0037474152     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1079700     Document Type: Article

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33. We thank K. Hodgson for Fig. 1, M. Isaacson for obtaining Fig. 3D, and Amersham Biosciences for providing R110-dCTP. Supported by grant DE-FG02-99ER62809 from the U.S. Department of Energy. Additional support was received from NSF grant DBI-0080792 and from the facilities of National Center for Research Resources -NIH Biomedical Technology Resource, grant P41RR04224, and the Nanobiotechnology Center, NSF-Science and Technology Center grant agreement ECS-9876771. Device fabrication was performed at the Cornell Nanofabrication Facility.