Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo

FASEB Journal

Volumn 28, Issue 3, 2014, Pages 1157-1165

  Lee, Kristen L ^a   Hoey, David A ^a,b,c   Spasic, Milos ^a,d   Tang, Tong ^e,f   Hammond, H Kirk ^e,f   Jacobs, Christopher R ^a  

^a Department of Biomedical Engineering Columbia University ^*  (United States)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c UNIVERSITY OF LIMERICK   (Ireland)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Fluid flow; Mechanical loading; Mechanotransduction

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE 6; ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; CYCLIC AMP; CYCLOOXYGENASE 2 INHIBITOR; PARATHYROID HORMONE; UNCLASSIFIED DRUG; ADENYLYL CYCLASE 6; CYCLOOXYGENASE 2; MESSENGER RNA;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; BONE CELL; CELL ISOLATION; CONTROLLED STUDY; ENZYME MECHANISM; EUKARYOTIC FLAGELLUM; FEMALE; GENE DELETION; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MECHANOTRANSDUCTION; MORPHOLOGICAL ADAPTATION; MORPHOLOGY; MORPHOMETRICS; MOUSE; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; OSSIFICATION; OSTEOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECOND MESSENGER; WILD TYPE; ADAPTATION; ANIMAL; BONE; C57BL MOUSE; FLUID FLOW; GENETICS; MECHANICAL LOADING; METABOLISM; PHENOTYPE; PHYSIOLOGY; TRANSGENIC MOUSE;

FLUID FLOW; MECHANICAL LOADING; MECHANOTRANSDUCTION;

ADAPTATION, PHYSIOLOGICAL; ADENYLATE CYCLASE; ANIMALS; BONE AND BONES; CYCLOOXYGENASE 2; FEMALE; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHENOTYPE; RNA, MESSENGER;

EID: 84899573128     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-240432     Document Type: Article

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