Identification and characterization of small molecule modulators of the epstein-barr virus-induced gene 2 (EBI2) receptor

Journal of Medicinal Chemistry

Volumn 57, Issue 8, 2014, Pages 3358-3368

  Gessier, Francois ^a   Preuss, Inga ^a   Yin, Hong ^b   Rosenkilde, Mette M ^c   Laurent, Stephane ^a   Endres, Ralf ^a   Chen, Yu A ^b,e   Marsilje, Thomas H ^b   Seuwen, Klaus ^a   Nguyen, Deborah G ^b,d   Sailer, Andreas W ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Organovo Inc   (United States)

^e NGM Biopharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 (2,3 DIHYDROBENZOFURAN 5 CARBONYL)PIPERAZIN 1 YL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (3,4 DIMETHYLBENZOYL)PIPERAZIN 1 YL]3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (4 BROMOBENZOYL)PIPERAZIN 1 YL] 3 (4 METHOXYPHENYL) PROP 2 EN 1 ONE; 1 [4 (4 CHLORO 3 METHYLBENZOYL)PIPERAZIN 1 YL] 3 (4 METHOXYPHENYL) PROP 2 EN 1 ONE; 1 [4 (4 METHOXYBENZOYL)PIPERAZIN 1 YL] 3 (4 METHOXYPHENYL) PROP 2 EN 1 ONE; 1 [4 [4 (DIMETHYLAMINO)BENZOYL]PIPERAZIN 1 YL] 3 (4 METHOXYPHENYL) PROP 2 EN 1 ONE; 3 (4 BROMOPHENYL) 1 [4 (2,3 DIHYDROBENZOFURAN 6 CARBONYL)PIPERAZIN 1 YL] PROP 2 EN 1 ONE; 3 (4 BROMOPHENYL) 1 [4 (4 METHOXYBENZOYL)PIPERAZIN 1 YL] PROP 2 EN 1 ONE; 3 (4 CHLOROPHENYL) 1 [4 (2,3 DIHYDROBENZOFURAN 6 CARBONYL)PIPERAZIN 1 YL] PROP 2 EN 1 ONE; 3 (4 METHOXYPHENYL) 1 [4 (3 METHYLBENZOYL)PIPERAZIN 1 YL] PROP 2 EN 1 ONE; 3 (4 METHOXYPHENYL) 1 [4 (4 METHYLBENZOYL)PIPERAZIN 1 YL] PROP 2 EN 1 ONE; 3 (4 METHOXYPHENYL) 1 [4 [4 (TRIFLUOROMETHYL)BENZOYL)PIPERAZIN 1 YL] PROP 2 EN 1 ONE; BETA GALACTOSIDASE; CALCIUM; EPSTEIN BARR VIRUS INDUCED GENE 2 RECEPTOR; EPSTEIN BARR VIRUS INDUCED GENE 2 RECEPTOR ANTAGONIST; G PROTEIN COUPLED RECEPTOR; METHYL 4 [4 [3 (4 METHOXYPHENYL)ACRYLOYL]PIPERAZINE 1 CARBONYL]BENZOATE; NIBR 127; NIBR 189; OXYSTEROL; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALCIUM CELL LEVEL; CELL MIGRATION; CHO CELL LINE; DENDRITIC CELL; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG ISOLATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME ACTIVITY; FEMALE; IN VITRO STUDY; LIVER MICROSOME; MALE; MAXIMUM PLASMA CONCENTRATION; MONOCYTE; MOUSE; NONHUMAN; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CALCIUM; CHO CELLS; CRICETULUS; HERPESVIRUS 4, HUMAN; HUMANS; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, G-PROTEIN-COUPLED; U937 CELLS;

EID: 84899566046     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4019355     Document Type: Article

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