Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation

FEBS Open Bio

Volumn 3, Issue , 2013, Pages 156-160

  Benned Jensen, Tau ^a   Madsen, Christian M ^a   Arfelt, Kristine N ^a   Smethurts, Christian ^b   Blanchard, Andy ^b   Jepras, Robert ^b   Rosenkilde, Mette M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

7TM receptors; Antagonism; EBI2; Epstein Barr virus; MAP kinase activation; Oxysterols

Indexed keywords

BETA ARRESTIN; EPSTEIN BARR VIRUS INDUCED GENE 2; G PROTEIN COUPLED RECEPTOR; GSK 68275A; MITOGEN ACTIVATED PROTEIN KINASE; OXYSTEROL; PERTUSSIS TOXIN; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CHEMOTAXIS; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION;

EID: 84874580095     PISSN: 22115463     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fob.2013.02.003     Document Type: Article

References (20)

1. Rosenkilde M.M., Benned-Jensen T., Andersen H., Holst P.J., Kledal T.N., Luttichau H.R., Larsen J.K., Christensen J.P., Schwartz T.W. Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity. J. Biol. Chem. 2006, 281:13199-13208.
2. Birkenbach M., Josefsen K., Yalamanchili R., Lenoir G., Kieff E. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 1993, 67:2209-2220.
3. Pereira J.P., Kelly L.M., Xu Y., Cyster J.G. EBI2 mediates B cell segregation between the outer and centre follicle. Nature 2009, 460:1122-1126.
4. Gatto D., Paus D., Basten A., Mackay C.R., Brink R. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 2009, 31:259-269.
5. Liu C., Yang X.V., Wu J., Kuei C., Mani N.S., Zhang L., Yu J., Sutton S.W., Qin N., Banie H., Karlsson L., Sun S., Lovenberg T.W. Oxysterols direct B-cell migration through EBI2. Nature 2011, 475:519-523.
6. Hannedouche S., Zhang J., Yi T., Shen W., Nguyen D., Pereira J.P., Guerini D., Baumgarten B.U., Roggo S., Wen B., Knochenmuss R., Noel S., Gessier F., Kelly L.M., Vanek M., Laurent S., Preuss I., Miault C., Christen I., Karuna R., Li W., Koo D.I., Suply T., Schmedt C., Peters E.C., Falchetto R., Katopodis A., Spanka C., Roy M.O., Detheux M., Chen Y.A., Schultz P.G., Cho C.Y., Seuwen K., Cyster J.G., Sailer A.W. Oxysterols direct immune cell migration via EBI2. Nature 2011, 475:524-527.
7. Yi T., Wang X., Kelly L.M., An J., Xu Y., Sailer A.W., Gustafsson J.A., Russell D.W., Cyster J.G. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity 2012, 37:535-548.
8. Benned-Jensen T., Rosenkilde M.M. Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist. Mol. Pharmacol. 2008, 74:1008-1021.
9. Benned-Jensen T., Norn C., Laurent S., Madsen C.M., Larsen H.M., Arfelt K.N., Wolf R.M., Frimurer T., Sailer A.W., Rosenkilde M.M. Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183). J. Biol. Chem. 2012, 287:35470-35483.
10. Zhang L., Shih A.Y., Yang X.V., Kuei C., Wu J., Deng X., Mani N.S., Mirzadegan T., Sun S., Lovenberg T.W., Liu C. Identification of structural motifs critical for EBI2 function and homology modeling of ligand docking site. Mol. Pharmacol. 2012, 82:1094-1103.
11. Rosenkilde M.M., Benned-Jensen T., Frimurer T.M., Schwartz T.W. The minor binding pocket: a major player in 7TM receptor activation. Trends Pharmacol. Sci. 2010, 31:567-574.
12. Alizadeh A.A., Eisen M.B., Davis R.E., Ma C., Lossos I.S., Rosenwald A., Boldrick J.C., Sabet H., Tran T., Yu X., Powell J.I., Yang L., Marti G.E., Moore T., Hudson J., Lu L., Lewis D.B., Tibshirani R., Sherlock G., Chan W.C., Greiner T.C., Weisenburger D.D., Armitage J.O., Warnke R., Levy R., Wilson W., Grever M.R., Byrd J.C., Botstein D., Brown P.O., Staudt L.M. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000, 403:503-511.
13. Aalto Y., El-Rifa W., Vilpo L., Ollila J., Nagy B., Vihinen M., Vilpo J., Knuutila S. Distinct gene expression profiling in chronic lymphocytic leukemia with 11q23 deletion. Leukemia 2001, 15:1721-1728.
14. Craig F.E., Johnson L.R., Harvey S.A., Nalesnik M.A., Luo J.H., Bhattacharya S.D., Swerdlow S.H. Gene expression profiling of Epstein-Barr virus-positive and -negative monomorphic B-cell posttransplant lymphoproliferative disorders. Diagn. Mol. Pathol. 2007, 16:158-168.
15. Cahir-McFarland E.D., Carter K., Rosenwald A., Giltnane J.M., Henrickson S.E., Staudt L.M., Kieff E. Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells. J. Virol. 2004, 78:4108-4119.
16. Benned-Jensen T., Smethurst C., Holst P.J., Page K.R., Sauls H., Sivertsen B., Schwartz T.W., Blanchard A., Jepras R., Rosenkilde M.M. Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist. J. Biol. Chem. 2011, 286:29292-29302.
17. Paulsen S.J., Rosenkilde M.M., Eugen-Olsen J., Kledal T.N. Epstein-Barr virus-encoded BILF1 is a constitutively active G protein-coupled receptor. J. Virol. 2005, 79:536-546.
18. Rummel P., Arfelt K., Baumann L., Jenkins T., Thiele S., Luttichau H., Johnsen A., Pease J., Ghosh S., Kolbeck R., Rosenkilde M. Molecular requirements for inhibition of the chemokine receptor CCR8 - probe-dependent allosteric interactions. Br. J. Pharmacol. 2012, 167:1206-1217.
19. Young L.S., Rickinson A.B. Epstein-Barr virus: 40 years on. Nat. Rev. Cancer 2004, 4:757-768.
20. Lyngaa R., Norregaard K., Kristensen M., Kubale V., Rosenkilde M.M., Kledal T.N. Cell transformation mediated by the Epstein-Barr virus G protein-coupled receptor BILF1 is dependent on constitutive signaling. Oncogene 2010, 29:4388-4398.