Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Lin, Yu Fen ^a   Nagasawa, Hatsumi ^b   Little, John B ^c   Kato, Takamitsu A ^b   Shih, Hung Ying ^a   Xie, Xian Jin ^d   Wilson Jr , Paul F ^e   Brogan, John R ^b   Kurimasa, Akihiro ^f   Chen, David J ^a   Bedford, Joel S ^b   Chen, Benjamin P C ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e BROOKHAVEN NATIONAL LABORATORY   (United States)

^f TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FANCONI ANEMIA GROUP G PROTEIN; PROTEIN KINASE C; RAD51 PROTEIN; RAD51C PROTEIN; RAD51D PROTEIN; UNCLASSIFIED DRUG; DNA DEPENDENT PROTEIN KINASE;

ALPHA RADIATION; ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL KILLING; CELL POPULATION; CELL SURVIVAL; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CLONOGENESIS; COLONY FORMATION; CONTROLLED STUDY; DNA END JOINING REPAIR; DOSE RESPONSE; ENZYME PHOSPHORYLATION; GAMMA IRRADIATION; GAMMA RADIATION; GENE MUTATION; NONHUMAN; PHENOTYPE; PROTEIN DOMAIN; RADIATION DOSE; RADIOSENSITIVITY; RECOMBINATION REPAIR; SISTER CHROMATID EXCHANGE; AMINO ACID SUBSTITUTION; ANIMAL; CHO CELL LINE; CRICETULUS; GENETICS; HUMAN; RADIATION RESPONSE;

ALPHA PARTICLES; AMINO ACID SUBSTITUTION; ANIMALS; CHO CELLS; CHROMOSOME ABERRATIONS; CRICETULUS; DNA END-JOINING REPAIR; DNA-ACTIVATED PROTEIN KINASE; GAMMA RAYS; HUMANS; RADIATION TOLERANCE; RECOMBINATIONAL DNA REPAIR; SISTER CHROMATID EXCHANGE;

EID: 84899555127     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093579     Document Type: Article

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