Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations

Radiation Research

Volumn 164, Issue 2, 2005, Pages 141-147

  Nagasawa, H ^a   Peng, Y ^a   Wilson, P F ^a   Lio, Y C ^b   Chen, D J ^b   Bedford, J S ^a   Little, J B ^c,d  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d Building 1 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA RADIATION; ANIMAL CELL; ARTICLE; BYSTANDER EFFECT; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL SYNCHRONIZATION; CHROMOSOME ABERRATION; CONTROLLED STUDY; GENETIC RECOMBINATION; HAMSTER; NONHUMAN; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE;

NASA DISCIPLINE CELL BIOLOGY; NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

ALPHA PARTICLES; ANIMALS; BYSTANDER EFFECT; CHROMOSOME ABERRATIONS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, RADIATION; RECOMBINATION, GENETIC; SISTER CHROMATID EXCHANGE;

CRICETINAE;

EID: 22944439752     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3420     Document Type: Article

References (27)

1. J. B. Little, Radiation carcinogenesis. Carcinogenesis 21, 397-404 (2000).
2. A. J. Pierce, J. M. Stark, F. D. Araujo, M. E. Moynahan, M. Berwick and M. Jasin, Double-strand breaks and tumorigenesis. Trends Cell Biol. 11, S52-S59 (2001).
3. K. K. Khanna and S. P. Jackson, DNA double-strand breaks: Signaling, repair and the cancer connection. Nat. Genet. 27, 247-254 (2001).
4. G. Iliakis, H. Wang, A. R. Perrault, W. Boecker, B. Rosidi, F. Windhofer, W. Wu, J. Guan, G. Terzoudi and G. Pantelias, Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenet. Genome Res. 104, 14-20 (2004).
5. H. Nagasawa and J. B. Little, Induction of sister chromatid exchanges by extremely low-doses of alpha-particles. Cancer Res. 52, 6394-6396 (1992).
6. H. Nagasawa and J. B. Little, Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: Evidence for a bystander effect. Radiat. Res. 152, 552-557 (1999).
7. J. B. Little, H. Nagasawa, G. C. Li and D. J. Chen, Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations. Radiat. Res. 159, 262-267 (2003).
8. L. H. Huo, H. Nagasawa and J. B. Little, HPRT mutants induced in bystander cells by very low fluences of alpha particles result primarily from point mutations. Radiat. Res. 156, 521-525 (2001).
9. H. Nagasawa, L. H. Huo and J. B. Little, Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells. Int. J. Radiat. Biol. 79, 35-41 (2003).
10. E. I. Azzam, S. M. de Toledo, D. R. Spitz and J. B. Little, Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res. 62, 5436-5442 (2002).
11. L. H. Thompson and C. L. Limoli, Origin, recognition, signaling, and repair of DNA double-strand breaks in mammalian cells. In Eukaryotic DNA Damage Surveillance and Repair (K. W. Caldecott, Ed.), pp. 107-145. Landes Bioscience, Georgetown, TX, 2004.
12. E. Sonoda, M. S. Sasaki, C. Morrison, Y. Yamaguchi-Iwai, M. Takata and S. Takeda, Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol. Cell. Biol. 19, 5l66-5169 (1999).
13. R. D. Johnson and M. Jasin, Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells. EMBO J. 19, 3398-3407 (2000).
14. W. Heyer, A new deal for Holliday junction. Nat. Struct. Mol. Biol. 11, 117-119 (2004).
15. Y. L. Liu, J. Y. Masson, R. Shah, P. O'Regan and S. C. West, RAD51C is required for Holliday junction processing in mammalian cells. Science 303, 243-246 (2004).
16. C. A. French, J. Y. Masson, C. S. Griffin, P. O'Regan, S. C. West and J. Thacker, Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J. Biol. Chem. 277, 19322-19330 (2002).
17. G. F. Whitmore, A. J. Varghese and S. Gulyas, Cell-cycle responses of 2 x-ray sensitive mutants defective in DNA-repair. Int. J. Radiat. Biol. 56, 657-665 (1989).
18. S. R. Peterson, A. Kurimasa, M. Oshimura, W. S. Dynan, E. M. Bradbury and D. J. Chen, Loss of the catalytic subunit of the DNA-dependent protein-kinase in DNA double-strand-break-repair mutant mammalian-cells. Proc. Natl. Acad. Sci. USA 92, 3171-3174 (1995).
19. Q. Ding, Y. V. R. Reddy, W. Wang, T. Woods, P. Douglas, D. A. Ramsden, S. P. Lees-Miller and K. Meek, Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Mol. Cell Biol. 23, 5836-5848 (2003).
20. H. Nagasawa, J. B. Little, W. C. Inkret, S. Carpenter, M. R. Raju, D. J. Chen and G. F. Strniste, Response of X-ray-sensitive CHO mutant cells (xrs-6) to radiation. II. Relationship between cell survival and the induction of chromosomal damage with low doses of alpha particles. Radiat. Res. 126, 280-288 (1991).
21. Y. L. Peng, Q. M. Zhang, H. Nagasawa, R. Okayasu, H. L. Liber and J. S. Bedford, Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation. Cancer Res. 62, 6400-6404 (2002).
22. N. F. Metting, A. M. Koehler, H. Nagasawa, J. M. Nelson and J. B. Little, Design of a benchtop alpha-particle irradiator. Health Phys. 68, 710-715 (1995).
23. M. R. Raju, Y. Eisen, S. Carpenter and W. C. Inkret, Radiobiology of alpha particles. 3. Cell inactivation by alpha-particle traversals of the cell nucleus. Radiat. Res. 128, 204-209 (1991).
24. P. Perry and S. Wolff, New Giemsa method for differential staining of sister chromatids. Nature 251, 156-158 (1974).
25. H. Nagasawa, A. Cremesti, R. Kolesnick, Z. Fuks and J. B. Little, Involvement of membrane signaling in the bystander effect in irradiated cells. Cancer Res. 62, 2531-2534 (2002).
26. P. K. Narayanan, E. H. Goodwin and B. E. Lehnert, Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Res. 57, 3963-3971 (1997).
27. M. A. Bender, H. G. Griggs and J. S. Bedford, Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation. Mutat. Res. 23, 197-212 (1974).