CTC1 increases the radioresistance of human melanoma cells by inhibiting telomere shortening and apoptosis

International Journal of Molecular Medicine

Volumn 33, Issue 6, 2014, Pages 1484-1490

  Luo, Y M ^a   Xia, N X ^a   Yang, L ^a   Li, Z ^a   Yang, H ^a   Yu, H J ^a   Liu, Y ^a   Lei, H ^a   Zhou, F X ^a   Xie, C H ^a   Zhou, Y F ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Conserved telomere maintenance component 1; Radioresistance; Telomere binding protein

Indexed keywords

CONSERVED TELOMERE MAINTE COMPONENT 1 PROTEIN; HISTONE H2AX; PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CTC1 PROTEIN, HUMAN; TELOMERE BINDING PROTEIN;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MELANOMA CELL LINE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RADIOSENSITIVITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TELOMERE HOMEOSTASIS; TELOMERE SHORTENING; WESTERN BLOTTING; DOUBLE STRANDED DNA BREAK; GENETICS; MELANOMA; METABOLISM; PHYSIOLOGY; TELOMERE; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; HUMANS; MELANOMA; TELOMERE; TELOMERE SHORTENING; TELOMERE-BINDING PROTEINS;

EID: 84899496326     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1721     Document Type: Article

References (33)

1. Miller AJ and Mihm MC Jr.: Melanoma. N Engl J Med 355: 51-65, 2006.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin 59: 225-249, 2009.
3. Little JB, Hahn GM, Frindel E and Tubiana M: Repair of potentially lethal radiation damage in vitro and in vivo. Radiology 106: 689-694, 1973.
4. Jenrette JM: Malignant melanoma: the role of radiation therapy revisited. Semin Oncol 23: 759-762, 1996.
5. Stevens G and McKay MJ: Dispelling the myths surrounding radiotherapy for treatment of cutaneous melanoma. Lancet Oncol 7: 575-583, 2006. (Pubitemid 43923675)
6. Rofstad EK: Radiation biology of malignant melanoma. Acta Radiol Oncol 25: 1-10, 1986.
7. Overgaard J, Overgaard M, Hansen PV and von der Maase H: Some factors of importance in the radiation treatment of malignant melanoma. Radiother Oncol 5: 183-192, 1986. (Pubitemid 16125844)
8. Khan N, Khan MK, Almasan A, Singh AD and Macklis R: The evolving role of radiation therapy in the management of malignant melanoma. Int J Radiat Oncol Biol Phys 80: 645-654, 2011.
9. Arienti C, Tesei A, Carloni S, et al: SLUG silencing increases radiosensitivity of melanoma cells in vitro. Cell Oncol (Dordr) 36: 131-139, 2013.
10. de Lange T: Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev 19: 2100-2110, 2005.
11. Palm W and de Lange T: How shelterin protects mammalian telomeres. Annu Rev Genet 42: 301-334, 2008.
12. Baumann P and Price C: Pot1 and telomere maintenance. FEBS Lett 584: 3779-3784, 2010.
13. Wang F and Lei M: Human telomere POT1-TPP1 complex and its role in telomerase activity regulation. Methods Mol Biol 735: 173-187, 2011.
14. Miyake Y, Nakamura M, Nabetani A, et al: RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell 36: 193-206, 2009.
15. Song X, Leehy K, Warrington RT, Lamb JC, Surovtseva YV and Shippen DE: STN1 protects chromosome ends in Arabidopsis thaliana. Proc Natl Acad Sci USA 105: 19815-19820, 2008.
16. Price CM, Boltz KA, Chaiken MF, Stewart JA, Beilstein MA and Shippen DE: Evolution of CST function in telomere maintenance. Cell Cycle 9: 3157-3165, 2010.
17. Mangino M, Hwang SJ, Spector TD, et al: Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet 21: 5385-5394, 2012.
18. Surovtseva YV, Churikov D, Boltz KA, et al: Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes. Mol Cell 36: 207-218, 2009.
19. Chen LY, Redon S and Lingner J: The human CST complex is a terminator of telomerase activity. Nature 488: 540-544, 2012.
20. Ning S, Shui C, Khan WB, Benson W, Lacey DL and Knox SJ: Effects of keratinocyte growth factor on the proliferation and radiation survival of human squamous cell carcinoma cell lines in vitro and in vivo. Int J Radiat Oncol Biol Phys 40: 177-187, 1998. (Pubitemid 28027584)
21. Cook PJ, Ju BG, Telese F, Wang X, Glass CK and Rosenfeld MG: Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 458: 591-596, 2009.
22. Campisi J, Kim SH, Lim CS and Rubio M: Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol 36: 1619-1637, 2001. (Pubitemid 32982869)
23. Smith CD and Blackburn EH: Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast. J Cell Biol 145: 203-214, 1999. (Pubitemid 29198295)
24. Maes L, Van Neste L, Van Damme K, et al: Relation between telomerase activity, hTERT and telomere length for intracranial tumours. Oncol Rep 18: 1571-1576, 2007.
25. Castella M, Puerto S, Creus A, Marcos R and Surralles J: Telomere length modulates human radiation sensitivity in vitro. Toxicol Lett 172: 29-36, 2007. (Pubitemid 47126218)
26. Tang T, Zhou FX, Lei H, et al: Increased expression of telomere-related proteins correlates with resistance to radiation in human laryngeal cancer cell lines. Oncol Rep 21: 1505-1509, 2009.
27. Ayouaz A, Raynaud C, Heride C, Revaud D and Sabatier L: Telomeres: hallmarks of radiosensitivity. Biochimie 90: 60-72, 2008. (Pubitemid 350216220)
28. Zhou FX, Xiong J, Luo ZG, et al: cDNA expression analysis of a human radiosensitive-radioresistant cell line model identifies telomere function as a hallmark of radioresistance. Radiat Res 174: 550-557, 2010.
29. Drissi R, Wu J, Hu Y, Bockhold C and Dome JS: Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells. Cancer Prev Res (Phila) 4: 1973-1981, 2011.
30. Berardinelli F, Nieri D, Sgura A, Tanzarella C and Antoccia A: Telomere loss, not average telomere length, confers radiosensitivity to TK6-irradiated cells. Mutat Res 740: 13-20, 2012.
31. Gu P, Min JN, Wang Y, et al: CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J 31: 2309-2321, 2012.
32. Anderson BH, Kasher PR, Mayer J, et al: Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus. Nat Genet 44: 338-342, 2012.
33. Eriksson D and Stigbrand T: Radiation-induced cell death mechanisms. Tumour Biol 31: 363-372, 2010.