The evolving role of radiation therapy in the management of malignant melanoma

International Journal of Radiation Oncology Biology Physics

Volumn 80, Issue 3, 2011, Pages 645-654

  Khan, Niloufer ^a   Khan, Mohammad K ^b,c   Almasan, Alex ^b   Singh, Arun D ^b   MacKlis, Roger ^b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

^c TAUSSIG CANCER INSTITUTE   (United States)

Author keywords

Biological agents; Brachytherapy; Hypofractionation; Melanoma cell cycle; Radiosurgery

Indexed keywords

BIOLOGICAL AGENTS; BRACHYTHERAPY; HYPOFRACTIONATION; MELANOMA CELL CYCLE; RADIOSURGERY;

BODY FLUIDS; DERMATOLOGY; ONCOLOGY; PATHOLOGY;

RADIOTHERAPY;

B RAF KINASE; CYCLIN D; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INTEGRIN; IPILIMUMAB; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P53; PROTEIN TYROSINE KINASE; RETINOBLASTOMA PROTEIN; SORAFENIB; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR SLUG; UVOMORULIN; VEMURAFENIB;

BRACHYTHERAPY; BRAIN METASTASIS; BRAIN RADIATION; CANCER RECURRENCE; CELL CYCLE; DISEASE COURSE; GAMMA KNIFE RADIOSURGERY; HUMAN; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MELANOMA; MISSENSE MUTATION; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; REVIEW; STEREOTACTIC RADIOSURGERY; UVEA MELANOMA;

BRACHYTHERAPY; BRAIN NEOPLASMS; CELL CYCLE; CELL SURVIVAL; CRANIAL IRRADIATION; HEAD AND NECK NEOPLASMS; HUMANS; LYMPH NODE EXCISION; LYMPHATIC IRRADIATION; LYMPHATIC METASTASIS; MELANOMA; NEOPLASM RECURRENCE, LOCAL; RADIATION TOLERANCE; RADIOSURGERY; UVEAL NEOPLASMS;

EID: 79957541238     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2010.12.071     Document Type: Review

References (71)

1. G.M. MacKee, A.C. Cipollaro, and H. Montgomery X-rays and radium in the treatment of diseases of the skin 4th ed. 1946 Lea & Febiger Philadelphia
2. R.R. Million, and N.J. Cassisi Management of head and neck cancer: A multidisciplinary approach 1984 Lippincott Philadelphia
3. J.M. Jenrette Malignant melanoma: The role of radiation therapy revisited Semin Oncol 23 1996 759 762
4. G. Stevens, and M.J. McKay Dispelling the myths surrounding radiotherapy for treatment of cutaneous melanoma Lancet Oncol 7 2006 575 583 (Pubitemid 43923675)
5. J. Overgaard, M. Overgaard, P.V. Hansen, and H. von der Maase Some factors of importance in the radiation treatment of malignant melanoma Radiother Oncol 5 1986 183 192 (Pubitemid 16125844)
6. E.K. Rofstad Radiation biology of malignant melanoma Acta Radiol Oncol 25 1986 1 10 (Pubitemid 16111189)
7. A. Jemal, R. Siegel, and E. Ward Cancer statistics, 2009 CA Cancer J Clin 59 2009 225 249
8. M.J. Homer, L.A.G. Ries, and M. Krapcho SEER Cancer Statistics Review, 1975-2006 2009 National Cancer Institute Bethseda, MD Available at http://seer.cancer.gov/csr/1975-2006/ Accessed April 3, 2010
9. C.M. Balch, J.E. Gershenwald, and S.J. Soong Final version of 2009 AJCC melanoma staging and classification J Clin Oncol 27 2009 6199 6206
10. A.J. Miller, and M.C. Mihm Jr. Melanoma N Engl J Med 355 2006 51 65
11. A. Uong, and L.I. Zon Melanocytes in development and cancer J Cell Physiol 222 2010 38 41
12. K. Satyamoorthy, N.H. Chehab, and M.J. Waterman Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells Cell Growth Differ 11 2000 467 474
13. M.E. Crosby, and A. Almasan Opposing roles of E2Fs in cell proliferation and death Cancer Biol Ther 3 2004 1208 1211 (Pubitemid 41350953)
14. A. Almasan, Y. Yin, and R.E. Kelly Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis Proc Natl Acad Sci U S A 92 1995 5436 5440
15. S. Mazumder, E.L. DuPree, and A. Almasan A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy Curr Cancer Drug Targets 4 2004 65 75 (Pubitemid 38332565)
16. L.A. Fecher, S.D. Cummings, M.J. Keefe, and R.M. Alani Toward a molecular classification of melanoma J Clin Oncol 25 2007 1606 1620 (Pubitemid 46733089)
17. C. Nogueira, K.H. Kim, and H. Sung Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis Oncogene 2010 6222 6232
18. P. Helsing, D.A. Nymoen, and S. Ariansen Population-based prevalence of CDKN2A and CDK4 mutations in patients with multiple primary melanomas Genes Chromosomes Cancer 47 2008 175 184
19. Bisio A, Nasti S, Jordan JJ, et al. Functional analysis of CDKN2A/p16INK4a 5'-UTR variants predisposing to melanoma. Hum Mol Genet 15;19:1479-1491.
20. D.E. Freedberg, S.H. Rigas, and J. Russak Frequent p16-independent inactivation of p14ARF in human melanoma J Natl Cancer Inst 100 2008 784 795 (Pubitemid 351809672)
21. M.C. Scaini, E. Rossi, and P.L. de Siqueira Torres Functional impairment of p16(INK4A) due to CDKN2A p.Gly23Asp missense mutation Mutat Res 671 2009 26 32
22. W.B. Coley, and J.P. Hoquet Metastatic cancer, with a report of 91 patients Ann Surg 64 1916 206 241
23. W.B. Coley, and T. Leucutia The treatment of metastatic tumors of the skin: Pigmented moles and melanomas Am J Roentgen 11 1924 335 336
24. F. Ellis Radiosensitivity of malignant melanomata Br J Radiol 12 1939 327 352
25. W. Hellriegel Radiation therapy for primary and metastatic melanoma Ann N Y Acad Sci 100 1963 131 141
26. S.C. Barranco, M.M. Romsdahl, and R.M. Humphrey The radiation response of human malignant melanoma cells grown in vitro Cancer Res 31 1971 830 833
27. J. Overgaard, H. von der Maase, and M. Overgaard A randomized study comparing two high-dose per fraction radiation schedules in recurrent or metastatic malignant melanoma Int J Radiat Oncol Biol Phys 11 1985 1837 1839 (Pubitemid 16224025)
28. W.T. Sause, J.S. Cooper, and S. Rush Fraction size in external beam radiation therapy in the treatment of melanoma Int J Radiat Oncol Biol Phys 20 1991 429 432
29. D.T. Chang, R.J. Amdur, C.G. Morris, and W.M. Mendenhall Adjuvant radiotherapy for cutaneous melanoma: Comparing hypofractionation to conventional fractionation Int J Radiat Oncol Biol Phys 66 2006 1051 1055 (Pubitemid 44637160)
30. S.M. Bentzen, J. Overgaard, and H.D. Thames Clinical radiobiology of malignant melanoma Radiother Oncol 16 1989 169 182 (Pubitemid 20001695)
31. J.B. Konefal, B. Emami, and M.V. Pilepich Malignant melanoma: Analysis of dose fractionation in radiation therapy Radiology 164 1987 607 610 (Pubitemid 17144909)
32. K.K. Ang, R.M. Byers, and L.J. Peters Regional radiotherapy as adjuvant treatment for head and neck malignant melanoma. Preliminary results Arch Otolaryngol Head Neck Surg 116 1990 169 172 (Pubitemid 20051845)
33. J.M. Skibber, S.J. Soong, and L. Austin Cranial irradiation after surgical excision of brain metastases in melanoma patients Ann Surg Oncol 3 1996 118 123 (Pubitemid 126729498)
34. J.H. Sampson, J.H.J. Carter, A.H. Friedman, and H.F. Seigler Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma J Neurosurg 88 1998 11 20 (Pubitemid 28018958)
35. M.B. Atkins, J.A. Sosman, and S. Agarwala Temozolomide, thalidomide, and whole brain radiation therapy for patients with brain metastasis from metastatic melanoma: A phase II Cytokine Working Group study Cancer 113 2008 2139 2145
36. Y. Mori, D. Kondziolka, and J.C. Flickinger Stereotactic radiosurgery for cerebral metastatic melanoma: Factors affecting local disease control and survival Int J Radiat Oncol Biol Phys 42 1998 581 589 (Pubitemid 28501108)
37. U. Selek, E.L. Chang, and S. Hassenbusch Jr. Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases Int J Radiat Oncol Biol Phys 59 2004 1097 1106 (Pubitemid 38834303)
38. C. Yu, J.C. Chen, and M.L. Apuzzo Metastatic melanoma to the brain: Prognostic factors after gamma knife radiosurgery Int J Radiat Oncol Biol Phys 52 2002 1277 1287 (Pubitemid 34296488)
39. A.E. Radbill, J.F. Fiveash, and E.T. Falkenberg Initial treatment of melanoma brain metastases using gamma knife radiosurgery: An evaluation of efficacy and toxicity Cancer 101 2004 825 833 (Pubitemid 39030941)
40. M. Scorsetti, A. Facoetti, and P. Navarria Hypofractionated stereotactic radiotherapy and radiosurgery for the treatment of patients with radioresistant brain metastases Anticancer Res 29 2009 4259 4263
41. A. Stone, J. Cooper, and K.L. Koenig A comparison of survival rates for treatment of melanoma metastatic to the brain Cancer Invest 22 2004 492 497 (Pubitemid 39506868)
42. J.M. Van Raamsdonk, Y. Meng, and D. Camp Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage Genetics 185 2010 559 571
43. L.E. Zimmerman, I.W. McLean, and W.D. Foster Does enucleation of the eye containing a malignant melanoma prevent or accelerate the dissemination of tumour cells Br J Ophthalmol 62 1978 420 425 (Pubitemid 8357372)
44. The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma III: Local complications and observations following enucleation. COMS report no. 11 Am J Ophthalmol 126 1998 362 372
45. B.S. Hawkins The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality findings and prognostic factors. COMS report number 24 Am J Ophthalmol 138 2004 936 951
46. M. Diener-West, J.D. Earle, and S.L. Fine The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma, III: Initial mortality findings. COMS Report No. 18 Arch Ophthalmol 119 2001 969 982
47. E.S. Gragoudas Proton beam irradiation of uveal melanomas: The first 30 years. The Weisenfeld Lecture Invest Ophthalmol Vis Sci 47 2006 4666 4673 (Pubitemid 46586360)
48. Z.O. Toktas, A. Bicer, and G. Demirci Gamma knife stereotactic radiosurgery yields good long-term outcomes for low-volume uveal melanomas without intraocular complications J Clin Neurosci 17 2010 441 445
49. M.D. Moncrieff, R. Martin, and C.J. O'Brien Adjuvant postoperative radiotherapy to the cervical lymph nodes in cutaneous melanoma: Is there any benefit for high-risk patients? Ann Surg Oncol 15 2008 3022 3027
50. M.T. Ballo, and K.K. Ang Radiotherapy for cutaneous malignant melanoma: Rationale and indications Oncology (Williston Park) 18 2004 99 107 discussion 107-110, 113-104
51. S. Verma, I. Quirt, D. McCready, and K. Bak Systematic review of systemic adjuvant therapy for patients at high risk for recurrent melanoma Cancer 106 2006 1431 1442
52. B.H. Burmeister, B. Mark Smithers, and E. Burmeister A prospective Phase II study of adjuvant postoperative radiation therapy following nodal surgery in malignant melanoma-Trans Tasman Radiation Oncology Group (TROG) Study 96.06 Radiother Oncol 81 2006 136 142 (Pubitemid 44708373)
53. M.A. Henderson, B. Burmeister, and J.F. Thompson Adjuvant radiotherapy and regional lymph node field control in melanoma patients after lymphadenectomy: Results of an intergroup randomized trial (ANZMTG 01.02/TROG 02.01) J Clin Oncol 2009 27(18s)
54. S. Agrawal, J.M. Kane 3rd, and B.A. Guadagnolo The benefits of adjuvant radiation therapy after therapeutic lymphadenectomy for clinically advanced, high-risk, lymph node-metastatic melanoma Cancer 115 2009 5836 5844
55. M.T. Ballo, M.I. Ross, and J.N. Cormier Combined-modality therapy for patients with regional nodal metastases from melanoma Int J Radiat Oncol Biol Phys 64 2006 106 113 (Pubitemid 41831216)
56. S. Temam, G. Mamelle, and P. Marandas Postoperative radiotherapy for primary mucosal melanoma of the head and neck Cancer 15 103 2005 313 319 (Pubitemid 40129291)
57. J.M. Owens, D.B. Roberts, and J.N. Myers The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region Arch Otolaryngol Head Neck Surg 129 2003 864 868 (Pubitemid 36966432)
58. J.A. Curtin, K. Busam, D. Pinkel, and B.C. Bastian Somatic activation of KIT in distinct subtypes of melanoma J Clin Oncol 24 2006 4340 4346 (Pubitemid 46630793)
59. D. Handolias, A.L. Hamilton, and R. Salemi Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT Br J Cancer 102 2010 1219 1223
60. L.B. Berk Radiation therapy as primary and adjuvant treatment for local and regional melanoma Cancer Control 15 2008 233 238
61. S. Haferkamp, T.M. Becker, and L.L. Scurr p16INK4a-induced senescence is disabled by melanoma-associated mutations Aging Cell 7 2008 733 745
62. S.M. Johnson, C.D. Torrice, and J.F. Bell Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition J Clin Invest 120 2010 2528 2536
63. J. Tsai, J.T. Lee, and W. Wang Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity Proc Natl Acad Sci U S A 105 2008 3041 3046 (Pubitemid 351723664)
64. K.T. Flaherty, I. Puzanov, and K.B. Kim Inhibition of mutated, activated BRAF in metastatic melanoma N Engl J Med 363 Aug 26 2010 809 819
65. Gudkov AV, Komarova EA. Radioprotection: Smart games with death. J Clin Invest 23 2010.
66. J. Yang, R. Splittgerber, and F.E. Yull Conditional ablation of Ikkb inhibits melanoma tumor development in mice J Clin Invest 120 2010 2563 2574
67. G.E. Johnson, V.N. Ivanov, and T.K. Hei Radiosensitization of melanoma cells through combined inhibition of protein regulators of cell survival Apoptosis 13 2008 790 802
68. Y. Matsumura, N. Yamagishi, and J. Miyakoshi Increase in radiation sensitivity of human malignant melanoma cells by expression of wild-type p16 gene Cancer Lett 115 1997 91 96 (Pubitemid 27139859)
69. J. Overgaard The role of radiotherapy in recurrent and metastatic malignant melanoma: A clinical radiobiological study Int J Radiat Oncol Biol Phys 12 1986 867 872 (Pubitemid 16057568)
70. F.S. Hodi, S.J. O'Day, and D.F. McDermott Improved survival with ipilimumab in patients with metastatic melanoma N Engl J Med 363 2010 711 723
71. J.M. Kaminski, E. Shinohara, and J.B. Summers The controversial abscopal effect Cancer Treat Rev 31 2005 159 172 (Pubitemid 40790388)