Interferon-induced HERC5 is evolving under positive selection and inhibits HIV-1 particle production by a novel mechanism targeting Rev/RRE-dependent RNA nuclear export

Retrovirology

Volumn 11, Issue 1, 2014, Pages

  Woods, Matthew W ^a   Tong, Jessica G ^a   Tom, Sean K ^a   Szabo, Peter A ^a   Cavanagh, Peter C ^a   Dikeakos, Jimmy D ^a   Haeryfar, SM M ^a   Barr, Stephen D ^a  

^a WESTERN UNIVERSITY   (Canada)

Author keywords

Antiviral; E3 ligase; HERC5; HIV; Interferon; Nuclear export; Positive selection; Restriction; Retroviruses

Indexed keywords

INTERFERON; PROTEIN HERC5; RAN PROTEIN; REV PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VIRUS RNA;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE TARGETING; GENETIC SELECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR EVOLUTION; NONHUMAN; NUCLEAR EXPORT SIGNAL; PROTEIN PROTEIN INTERACTION; VIROGENESIS; VIRUS INHIBITION; VIRUS PARTICLE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ACTIVE TRANSPORT, CELL NUCLEUS; EVOLUTION, MOLECULAR; HIV-1; HUMANS; INTERFERONS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; REV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; RNA, VIRAL; SELECTION, GENETIC;

EID: 84899473135     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-11-27     Document Type: Article

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