HIV Integration Site Selection: Targeting in Macrophages and the Effects of Different Routes of Viral Entry

Molecular Therapy

Volumn 14, Issue 2, 2006, Pages 218-225

  Barr, Stephen D ^a,b   Ciuffi, Angela ^a   Leipzig, Jeremy ^a   Shinn, Paul ^c   Ecker, Joseph R ^c   Bushman, Frederic D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

envelope; gene therapy; HIV; integrase; integration; lentivirus; macrophages; retrovirus; vector; VSV G

Indexed keywords

VIRUS ENVELOPE PROTEIN;

ARTICLE; CELL DIVISION; CELL TYPE; CHROMOSOME ANALYSIS; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN IMMUNODEFICIENCY VIRUS; MACROPHAGE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; T LYMPHOCYTE; VIRUS DNA CELL DNA INTERACTION; VIRUS ENVELOPE; VIRUS PARTICLE;

BASE SEQUENCE; COMPUTATIONAL BIOLOGY; GENOME, HUMAN; GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTORS, RECOMBINANT; HIV-1; HUMANS; MACROPHAGES; MEMBRANE GLYCOPROTEINS; RECEPTORS, HIV; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; VIRAL ENVELOPE PROTEINS; VIRUS INTEGRATION;

VESICULAR STOMATITIS VIRUS;

EID: 33745363486     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2006.03.012     Document Type: Article

References (42)

1. Coffin J.M., Hughes S.H., and Varmus H.E. Retroviruses (1997), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
2. Stebbing J., Gazzard B., and Douek D.C. Where does HIV live?. N. Engl. J. Med. 350 (2004) 1872-1880
3. Verani A., Gras G., and Pancino G. Macrophages and HIV-1: dangerous liaisons. Mol. Immunol. 42 (2005) 195-212
4. Sharova N., Swingler C., Sharkey M., and Stevenson M. Macrophages archive HIV-1 virions for dissemination in trans. EMBO J. 24 (2005) 2481-2489
5. Schroder A., Shinn A., Chen H., Berry C., Ecker J.R., and Bushman F.D. HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110 (2002) 521-529
6. Wu X., Li Y., Crise B., and Burgess S.M. Transcription start regions in the human genome are favored targets for MLV integration. Science 300 (2003) 1749-1751
7. Mitchell R., et al. Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. PLoS Biol. 2 (2004) E234
8. Ciuffi A., et al. A role for LEDGF/p75 in targeting HIV DNA integration. Nat. Med. 11 (2005) 1287-1289
9. Barr S.D., Leipzig J., Shinn P., Ecker J.R., and Bushman F.D. Integration targeting by avian sarcoma-leukosis virus and human immunodeficiency virus in the chicken genome. J. Virol. 79 (2005) 12035-12044
10. Ciuffi A., et al. Integration site selection by HIV-based vectors: targeting in dividing and nondividing IMR-90 lung fibroblasts. Mol. Ther. 13 (2006) 366-373
11. Hematti P., et al. Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol. 2 (2004) E423
12. Narezkina A., et al. Genome-wide analyses of avian sarcoma virus integration sites. J. Virol. 78 (2004) 11656-11663
13. Stevens S.W., and Griffith J.D. Sequence analysis of the human DNA flanking sites of human immunodeficiency virus type 1 integration. J. Virol. 70 (1996) 6459-6462
14. Carteau S., Hoffmann C., and Bushman F.D. Chromosome structure and HIV-1 cDNA integration: centromeric alphoid repeats are a disfavored target. J. Virol. 72 (1998) 4005-4014
15. Holman A.G., and Coffin J.M. Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites. Proc. Natl. Acad. Sci. USA 102 (2005) 6103-6107
16. X. Wu, Y. Li, B. Crise, S.M. Burgess, and D.J. Munroe, Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses. J. Virol. 79.
17. Panet A., and Cedar H. Selective degradation of integrated murine leukemia proviral DNA by deoxyribonucleases. Cell 11 (1977) 933-940
18. Vijaya S., Steffan D.L., and Robinson H.L. Acceptor sites for retroviral integrations map near DNaseI-hypersensitive sites in chromatin. J. Virol. 60 (1986) 683-692
19. Rohdewohld H., Weiher H., Reik W., Jaenisch R., and Breindl M. Retrovirus integration and chromatin structure: Moloney murine leukemia proviral integration sites map near DNase I-hypersensitive sites. J. Virol. 61 (1987) 336
20. Sandmeyer S. Integration by design. Proc. Natl. Acad. Sci. USA 100 (2003) 5586-5588
21. Zhu Y., Dai J., Fuerst P.G., and Voytas D.F. Controlling integration specificity of yeast retrotransposon. Proc. Natl. Acad. Sci. USA 100 (2003) 5891-5895
22. Boeke J.D., and Devine S.E. Yeast retrotransposons: finding a nice quiet neighborhood. Cell 93 (1998) 1087-1089
23. Bushman F.D. Targeting survival: integration site selection by retroviruses and LTR-retrotransposons. Cell 115 (2003) 135-138
24. Bushman F., et al. Genome-wide analysis of retroviral DNA integration. Nat. Rev. Microbiol. 3 (2005) 848-858
25. Cherepanov P., et al. HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. J. Biol. Chem. 278 (2003) 372-381
26. Maertens G., et al. LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells. J. Biol. Chem. 278 (2003) 33528-33539
27. Turlure F., Devroe E., Silver P.A., et al., Engelman A. Human cell proteins and human immunodeficiency virus DNA integration. Front. Biosci. 9 (2004) 3187-3208
28. Llano M., et al. LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. J. Virol. 78 (2004) 9524-9537
29. Llano M., Delgado S., Vanegas M., and Poeschla E.M. LEDGF/p75 prevents proteasomal degradation of HIV-1 integrase. J. Biol. Chem. 279 (2004) 55570-55577
30. Cherepanov P., Ambrosio A.L., Rahman S., Ellenberger T., and Engelman A. Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. Proc. Natl. Acad. Sci. USA 102 (2005) 17308-17313
31. Roe T., Reynolds T.C., Yu G., and Brown P.O. Integration of murine leukemia virus DNA depends on mitosis. EMBO J. 12 (1993) 2099-2108
32. Lewis P., Hensel M., and Emerman M. Human immunodeficiency virus infection of cells arrested in the cell cycle. EMBO J. (1992) 3053-3058
33. Hwang S.S., Boyle T.J., Lyerly H.K., and Cullen B.R. Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science 253 (1991) 71-74
34. Smit A.F. Interspersed repeats and other mementos of transposable elements in mammalian genomes. Curr. Opin. Genet. Dev. 9 (1999) 657-663
35. Lander E., et al. Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921
36. Lewinski M., et al. Genome-wide analysis of chromosomal features repressing HIV transcription. J. Virol. 79 (2005) 6610-6619
37. Zhao L., et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat. Med. 10 (2004) 966-973
38. Chaussabel D., Semnani R.T., McDowell M.A., Sacks D., Sher A., and Nutman T.B. Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites. Blood 102 (2003) 672-681
39. Laufs S., et al. Retroviral vector integration occurs in preferred genomic targets in human bone marrow-repopulating cells. Blood 101 (2003) 2191-2198
40. Venter J.C. The sequence of the human genome. Science 291 (2001) 1304-1351
41. Follenzi A., Ailes L.E., Bakovic S., Gueuna M., and Naldini L. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat. Genet. 25 (2000) 217-222
42. Naldini L., et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272 (1996) 263-267