Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α, 5α-THP and reduces long-term operant ethanol self-administration

Journal of Neuroscience

Volumn 34, Issue 17, 2014, Pages 5824-5834

  Cook, Jason B ^a,b   Werner, David F ^a,c   Maldonado Devincci, Antoniette M ^a   Leonard, Maggie N ^a   Fisher, Kristen R ^a   O'Buckley, Todd K ^a   Porcu, Patrizia ^a,d   McCown, Thomas J ^a,b   Besheer, Joyce ^a,b   Hodge, Clyde W ^a,b   Leslie Morrow, A ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c BINGHAMTON UNIVERSITY   (United States)

^d CNR   (Italy)

Author keywords

Alcohol; Allopregnanolone; Neuroactive steroid; Neurosteroid; P450scc; Ventral tegmental area

Indexed keywords

22 HYDROXYCHOLESTEROL; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ADENOVIRUS VECTOR; BETA ACTIN; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); COMPLEMENTARY DNA; DIAMINOBENZIDINE; GLIAL FIBRILLARY ACIDIC PROTEIN; GREEN FLUORESCENT PROTEIN; NEURON SPECIFIC NUCLEAR PROTEIN; NEUROSTEROID; PREGNENOLONE; RESTRICTION ENDONUCLEASE; TYROSINE 3 MONOOXYGENASE;

ADULT; ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EXPERIMENTAL LOCOMOTOR ACTIVITY TEST; FIBROBLAST CULTURE; FUNCTIONAL NEUROIMAGING; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INVERTED TERMINAL REPEAT; MALE; MRNA EXPRESSION ASSAY; NEUROSTEROIDOGENESIS; NONHUMAN; NUCLEUS ACCUMBENS; OPEN FIELD TEST; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SELF ADMINISTRATION TEST; SIGNAL TRANSDUCTION; STEROIDOGENESIS; VENTRAL TEGMENTUM; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

ALCOHOL; ALLOPREGNANOLONE; NEUROACTIVE STEROID; NEUROSTEROID; P450SCC; VENTRAL TEGMENTAL AREA;

ALCOHOLS; ANIMALS; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CONDITIONING, OPERANT; ETHANOL; MALE; MOTOR ACTIVITY; PREGNANOLONE; RATS; RATS, WISTAR; SELF ADMINISTRATION; VENTRAL TEGMENTAL AREA;

EID: 84899472620     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4733-13.2014     Document Type: Article

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