Ethanol enhances neurosteroidogenesis in hippocampal pyramidal neurons by paradoxical NMDA receptor activation

Journal of Neuroscience

Volumn 31, Issue 27, 2011, Pages 9905-9909

  Tokuda, Kazuhiro ^a   Izumi, Yukitoshi ^a   Zorumski, Charles F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ALCOHOL; DUTASTERIDE; FINASTERIDE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GABAERGIC SYSTEM; HIPPOCAMPAL CA1 REGION; LONG TERM POTENTIATION; MALE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; RAT; STEROIDOGENESIS;

2-AMINO-5-PHOSPHONOVALERATE; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 5-ALPHA REDUCTASE INHIBITORS; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; AZASTEROIDS; CA1 REGION, HIPPOCAMPAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ELECTRIC STIMULATION; ETHANOL; EVOKED POTENTIALS; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION; LONG-TERM POTENTIATION; MALE; N-METHYLASPARTATE; NEURAL INHIBITION; NEUROGENESIS; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS;

EID: 79960068474     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1660-11.2011     Document Type: Article

References (27)

1. Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M (2010) An overview on 5alpha-reductase inhibitors. Steroids 75:109-153.
2. Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci U S A 103:14602-14607.
3. Bernardi F, Salvestroni C, Casarosa E, Nappi RE, Lanzone A, Luisi S, Purdy RH, Petraglia F, Genazzani AR (1998) Aging is associated with changes in allopregnanolone concentrations in brain, endocrine glands and serum in male rats. Eur J Endocrinol 138:316-321.
4. Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
5. Boyd KN, Kumar S, O'Buckley TK, Porcu P, Morrow AL (2010) Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis. J Neurochem 112:784-796.
6. Chefer V, Meis J, Wang G, Kuzmin A, Bakalkin G, Shippenberg T (2011) Repeated exposure to moderate doses of ethanol augments hippocampal glutamate neurotransmission by increasing release. Addict Biol 16:229-237.
7. Izumi Y, Clifford DB, Zorumski CF (1992a) Low concentrations of N-methyl-D-aspartate inhibit the induction of long-term potentiation in rat hippocampal slices. Neurosci Lett 137:245-248.
8. Izumi Y, Clifford DB, Zorumski CF (1992b) Inhibition of long-term potentiation by NMDA-mediated nitric oxide release. Science 257:1273-1276.
9. Izumi Y, Nagashima K, Murayama K, Zorumski CF (2005) Acute effects of ethanol on hippocampal long-term potentiation and long-term depression are mediated by different mechanisms. Neuroscience 136:509-517.
10. Izumi Y, Auberson YP, Zorumski CF (2006) Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors. J Neurosci 26:7181-7188.
11. Izumi Y, Murayama K, Tokuda K, Krishnan K, Covey DF, Zorumski CF (2007) GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices. Eur J Neurosci 26:1881-1888.
12. Izumi Y, Tokuda K, Zorumski CF (2008) Long-term potentiation inhibition by low level N-methyl-D-aspartate receptor activation involves calcineurin, nitric oxide and p38 MAP kinase. Hippocampus 18:258-265.
13. Kimoto T, Tsurugizawa T, Ohta Y, Makino J, Tamura Ho, Hojo Y, Takata N, Kawato S (2001) Neurosteroid synthesis by cytochrome p450-containing systems localized in the rat brain hippocampal neurons: N-methyl-Daspartate and calcium-dependent synthesis. Endocrinology 142:3578-3589.
14. Liu L, Wong TP, Pozza MF, Lingenhoehl K, Wang Y, Sheng M, Auberson YP, Wang YT (2004) Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 304:1021-1024.
15. Lovinger DM, White G, Weight FF (1989) Ethanol inhibits NMDAactivated ion current in hippocampal neurons. Science 243:1721-1724.
16. Martin SJ, Grimwood PD, Morris RG (2000) Synaptic plasticity and memory: an evaluation of the hypothesis. Annu Rev Neurosci 23:649-711.
17. Melendez RI, Hicks MP, Cagle SS, Kalivas PW (2005) Ethanol exposure decreases glutamate uptake in the nucleus accumbens. Alcohol Clin Exp Res 29:326-333.
18. Moghaddam B, Bolinao ML (1994) Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and nucleus accumbens. Neurosci Lett 178:99-102.
19. Murayama K, Zorumski CF, Izumi Y (2006) Effects of neurosteroid 3_-hydroxy-5_-pregnan-20-one on ethanol-mediated paired-pulse depression of population spikes in the CA1 region of rat hippocampal slices. Neurosci Lett 394:28-32.
20. Othman T, Sinclair CJ, Haughey N, Geiger JD, Parkinson FE (2002) Ethanol alters glutamate but not adenosine uptake in rat astrocytes: evidence for protein kinase C involvement. Neurochem Res 27:289-296.
21. Saalmann YB, Kirkcaldie MT, Waldron S, Calford MB (2007) Cellular distribution of theGABAA receptor-modulating 3α-hydrox, 5α-reduced pregnane steroids in the adult rat brain. J Neuroendocrinol 19:272-284.
22. Salazar M, Pariente JA, Salido GM, González A (2008) Ethanol induces glutamate secretion by Ca2_ mobilization and ROS generation in rat hippocampal astrocytes. Neurochem Int 52:1061-1067.
23. Sanna E, Talani G, Busonero F, Pisu MG, Purdy RH, Serra M, Biggio G (2004) Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus. J Neurosci 24:6521-6530.
24. Siggins GR, Roberto M, Nie Z (2005) The tipsy terminal: presynaptic effects of ethanol. Pharmacol Ther 107:80-98.
25. Tokuda K, O'Dell KA, Izumi Y, Zorumski CF (2010) Midazolam inhibits hippocampal longterm potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis. J Neurosci 30:16788-16795.
26. White AM (2003) What happened? Alcohol, memory blackouts and the brain. Alcohol Res Health 27:186-196.
27. Zorumski CF, Mennerick S, Izumi Y (1996) Assessment of synaptic effects of nitric oxide in hippocampal neurons. Methods Neurosci 31:282-299.