Structure-activity relationships of bisphenol a analogs at estrogen receptors (ERs): Discovery of an ERα-selective antagonist

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 14, 2013, Pages 4031-4036

  Maruyama, Keisuke ^a   Nakamura, Masaharu ^a   Tomoshige, Shusuke ^a   Sugita, Kazuyuki ^a   Makishima, Makoto ^b   Hashimoto, Yuichi ^a   Ishikawa, Minoru ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Antagonist; Estrogen receptor; Nuclear receptor

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN RECEPTOR; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA;

ARTICLE; BINDING AFFINITY; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION;

BENZHYDRYL COMPOUNDS; BINDING SITES; CRESOLS; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HUMANS; MOLECULAR DOCKING SIMULATION; PHENOLS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879419936     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.05.067     Document Type: Article

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