Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2402-2411

  Nakamura, Masahiko ^a   Aoyama, Atsushi ^a   Salim, Mohammed T A ^b   Okamoto, Mika ^b   Baba, Masanori ^b   Miyachi, Hiroyuki ^c   Hashimoto, Yuichi ^a   Aoyama, Hiroshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

Am580; Am80; Anti HCV agents; Phenanthridinone; Thalidomide

Indexed keywords

5 BUTYL 2 (1,1,1,3,3,3 HEXAFLUORO 2 HYDROXYPROPAN 2 YL)PHENANTHRIDIN 6(5H) ONE; 5 BUTYLBENZO[B]PHENANTHRIDIN 6(5H) ONE; ANTIVIRUS AGENT; PHENANTHRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HEPATITIS C; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; CELL LINE; DIARRHEA VIRUS 1, BOVINE VIRAL; DRUG DESIGN; GENE EXPRESSION REGULATION, VIRAL; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HEPACIVIRUS; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHENANTHRIDINES; RNA, VIRAL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

HEPATITIS C VIRUS;

EID: 77950141363     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.057     Document Type: Article

References (29)

1. Hashimoto Y. Arch. Pharm. Life Sci. 341 (2008) 536
2. Hosoda S., Matsuda D., Tomoda H., and Hashimoto Y. Mini-Rev. Med. Chem. 9 (2009) 572
3. Hosoda S., Aoyama H., Goto Y., Salim M.T.A., Okamoto M., Hashimoto M., Baba M., and Hashimoto Y. Bioorg. Med. Chem. Lett. 19 (2009) 3157
4. Nakamura M., Hamasaki T., Tokitou M., Baba M., Hashimoto Y., and Aoyama H. Bioorg. Med. Chem. 17 (2009) 4740
5. Hosoda S., Matsuda D., Tomoda H., Hashimoto M., Aoyama H., and Hashimoto Y. Bioorg. Med. Chem. Lett. 19 (2009) 4228
6. Koonin E.V., Wolf Y.I., and Karev G.P. Nature 420 (2002) 218
7. Grishin N.V. J. Struct. Biol. 134 (2001) 167
8. Koch M.A., Wittenberg L.-O., Basu S., Jeyaraj D.A., Gourzoulidou E., Reinecke K., Odermatt A., and Waldmann H. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 16721
9. Hashimoto Y. Curr. Med. Chem. 5 (1998) 163
10. Hashimoto Y. Bioorg. Med. Chem. 10 (2002) 461
11. Hashimoto Y. Mini-Rev. Med. Chem. 2 (2002) 543
12. Hashimoto Y., Tanatani A., Nagasawa K., and Miyachi H. Drugs Future 29 (2004) 383
13. Hashimoto Y. Cell Biol. Rev. 25 (1991) 209
14. Sako K., Aoyama H., Sato S., Hashimoto Y., and Baba M. Bioorg. Med. Chem. 16 (2008) 3780
15. Aoyama H., Sako K., Sato S., Nakamura M., Miyachi H., Baba M., and Hashimoto Y. Heterocycles 77 (2009) 779
16. Liang T.J., Rehermann B., Seeff L.B., and Hoofnagle J.H. Ann. Intern. Med. 132 (2000) 296
17. Hayashi P.H., and Di Bisceglie A.M. Med. Clin. North Am. 89 (2005) 371
18. Memon M.I., and Memon M.A. J. Viral Hepat. 9 (2002) 84
19. Echevarria-Mayo J.M. Enferm. Infecc. Microbiol. Clin. 24 (2006) 45
20. Bosch F.X., Ribes J., Cleries R., and Diaz M. Clin. Liver Dis. 9 (2005) 191
21. McHutchison J.G., Gordon S.C., Schiff E.R., Shiffman M.L., Lee W.M., Rustgi V.K., Goodman Z.D., Ling M.H., Cort S., and Albrecht J.K. N. Eng. J. Med. 339 (1998) 1485
22. Tan S.L., Pause A., Shi Y., and Sonenberg N. Nat. Rev. Drug Disc. 1 (2002) 867
23. Buckwold V.E., Beer B.E., and Donis R.O. Antiviral Res. 60 (2003) 1
24. Buckwold V.E., Wei J., Wenzel-Mathers M., and Russell J. Antimicrob. Agents Chemother. 47 (2003) 2293
25. Yanagida K., Baba C., and Baba M. Antiviral Res. 64 (2004) 195
26. Aoyama A., Aoyama H., Dodo K., Makishima M., Hashimoto Y., and Miyachi H. Heterocycles 76 (2008) 137
27. Miyachi H., Aoyama A., and Hashimoto Y. MedChemNews 19 2 (2009) 30
28. Ishii N., Watashi K., Hishiki T., Goto K., Inoue D., Hijikata M., Wakita T., Kato N., and Shimotohno K. J. Virol. 80 (2006) 4510
29. Li L., Liu J., Zhu L., Cutler S., Hasegawa H., Shan B., and Medina J.C. Bioorg. Med. Chem. Lett. 16 (2006) 1638