Protein tyrosine phosphatase-like protein IA2-antibodies plus glutamic acid decarboxylase 65 antibodies (GADA) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus

Clinical Chemistry

Volumn 43, Issue 12, 1997, Pages 2358-2363

  Borg, Henrik ^a,b   Fernlund, Per ^a   Sundkvist, Göran ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; ENZYME ANTIBODY; GLUTAMATE DECARBOXYLASE; PANCREAS ISLET CELL ANTIBODY; PROTEIN TYROSINE PHOSPHATASE; RADIOLIGAND;

ADOLESCENT; ARTICLE; AUTOIMMUNITY; CHILD; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOFLUORESCENCE TEST; INSULIN DEPENDENT DIABETES MELLITUS; LIGAND BINDING; MAJOR CLINICAL STUDY; MALE; RADIOASSAY;

EID: 0031438330     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/43.12.2358     Document Type: Article

References (23)

1. Landin-Olsson M, Palmer JP, Lernmark Å, Blom L, Sundkvist G, Nyström L, Dahlquist G. Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children. Diabetologia 1992;35:1068-73.
2. Bækkeskov S, Jan-Aanstoot H, Christgau S, Reetz A, Solimena M, Cascalho M, et al. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA synthesizing enzyme glutamate decarboxylase. Nature 1990;347:151-6.
3. Verge CF, Howard NJ, Rowley MJ, Mackay IR, Zimmer PZ, Egan M, et al. Anti-glutamate decarboxylase and other antibodies at the onset of childhood IDDM, a population-based study. Diabetologia 1994;37:1113-20.
4. 35S]GAD 65-ligand binding assay. Clin Chem 1997;43:779-85.
5. Payton MA, Hawkes CJ, Christie MR. Relationship of the 37,000-and 40,000-M, tryptic fragments of the islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA2 (ICA512). J Clin Invest 1995;1506-11.
6. Bonifacio E, Lampasona V, Genovese S, Ferrari M, Bosi E. Identification of protein tyrosine phosphatase-like insulin depen dent-related 37/40K autoantigen and a target for islet-cell antibodies. J Immunol 1995;155:5419-26.
7. Lan MS, Wasserfall C, Maclaren NK, Notkins AL. IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus. Med Sci 1996;93:6367-70.
8. Hawkes CJ, Wasmeier C, Christie MR, Hutton JC. Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2. Diabetes 1996;45:1187-92.
9. Notkins AL, Lu J, Li Q, Van derVegt FP, Wasserfall C, Maclaren NK, Lan MS. IA-2, IA-2b are major autoantigens in IDDM and the precursors of the 40 KDa and 37 KDa tryptic fragments. J Autoimmun 1996;9:677-82.
10. Kawasaki E, Eisenbart GS, Wasmeier C, Hutton JC. Autoantibodies to protein tyrosine phosphatase-like proteins in type 1 diabetes. Overlapping specificities to phogrin and ICA512/IA-2. Diabetes 1996;45:1344-9.
11. Samuelsson U, Ludvigsson J, Sundkvist G. Islet cell antibodies (ICA), insulin autoantibodies (IAA), islet cell surface antibodies (ICSA) and C-peptide in 1031 school children in a population with a high background incidence of IDDM. Diabetes Res Clin Pract 1994;26:155-62.
12. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning, a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989:1.21-31, 182-4.
13. Lan MS, Lu J, Goto Y, Notkins AL. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 1994;13:505-14.
14. Landin-Olsson M, Sundkvist G, Lernmark Å. Prolonged incubation in the two-color immunofluorescence test increases the prevalence of titres of islet cell antibodies in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1987;30:327-32.
15. Seissler J, Morgenthaler NG, Achenbach P, Lampeter EF, Glawe D, Payton M, et al. Combined screening for autoantibodies to IA-2 and antibodies to glutamic acid decarboxylase in first-degree relatives of patients with IDDM. Diabetologia 1996;39:1351-6.
16. Gorus FK, Goubert P, Semakula C, Vandewalle CL, De Schepper J, Scheen A, et al. IA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia 1997;40:95-9.
17. Aanstoot HJ, Kang SM, Kim J, Lindsay L, Roll U, Knip M, et al. Identification and characterisation of Glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes. J Clin Invest 1996;97:2772-83.
18. Myers AM, Rabin DU, Rowley MJ. Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase. Diabetes 1995;44: 1290-5.
19. r human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest 1987;79:926-34.
20. Sundkvist G, Velloso LA, Kämpe O, Rabinowe SL, Ivarsson SA, Lilja B, Karlsson FA. Glutamic acid decarboxylase antibodies, autonomic nerve antibodies and autonomic neuropathy in diabetic patients. Diabetologia 1994;37:293-9.
21. Sundkvist G, Hagopian WA, Landin-Olsson M, Lernmark Å, Ohlsson L, Ericsson C, Ahlmen J. Islet cell antibodies, but not glutamic acid decarboxylase antibodies, are decreased by plasmapheresis in patients with newly diagnosed insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1994;78:1159-65.
22. Batstra MR, Pina M, Quan J, Mulder P, de Beaufort CE, Bruining GJ, Aanstoot HJ. Fluctuations in GAD65 antibodies after clinical diagnosis of IDDM in young children. Diabetes Care 1997;20: 642-4.
23. McEvoy RC, Thomas NM, Greig F, Larson S, Vargas-Rodrigues I, Felix I, et al. Anti-islet autoantibodies detected by monoclonal antibody 1A2: further studies suggesting a role in the pathogenesis of IDDM. Diabetologia 1996;39:1365-71.