Modeling immune complex-mediated autoimmune inflammation

Journal of Theoretical Biology

Volumn 267, Issue 3, 2010, Pages 426-436

  Arazi, A ^a,b   Neumann, A U ^a,b  

^a BAR ILAN UNIVERSITY   (Israel)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Autoimmune diseases; Immune complexes; Inflammation; Positive feedback loop

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN;

ANTIGEN; CELL ORGANELLE; IMMUNE RESPONSE; INFECTIOUS DISEASE; MODELING;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; AUTOINFLAMMATORY DISEASE; B LYMPHOCYTE ACTIVATION; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); DISEASE COURSE; DISEASE SEVERITY; HUMAN; HYSTERESIS; IMMUNE COMPLEX DEPOSITION; IMMUNOPATHOGENESIS; MATHEMATICAL MODEL; METABOLIC CLEARANCE RATE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN SECRETION; RISK FACTOR; SENSITIVITY ANALYSIS; STEADY STATE; TISSUE INJURY;

ALGORITHMS; ANIMALS; ANTIGEN-ANTIBODY COMPLEX; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; CELL PROLIFERATION; FEEDBACK; HUMANS; INFLAMMATION; MODELS, IMMUNOLOGICAL;

EID: 77958153648     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2010.08.033     Document Type: Article

References (57)

1. Alexopoulos E., Seron D., Hartley R.B., Cameron J.S. Lupus nephritis: correlation of interstitial cells with glomerular function. Kidney Int. 1990, 37:100-109.
2. Barr S.G., Zonana-Nacach A., Magder L.S., Petri M. Patterns of disease activity in systemic lupus erythematosus. Arthritis Rheum. 1999, 42:2682-2688.
3. Borghans J.A., De Boer R.J. A minimal model for T-cell vaccination. Proc. Biol. Sci. 1995, 259:173-178.
4. Borghans J.A., De Boer R.J., Sercarz E., Kumar V. T cell vaccination in experimental autoimmune encephalomyelitis: a mathematical model. J. Immunol. 1998, 161:1087-1093.
5. Botto M., Walport M.J. C1q, autoimmunity and apoptosis. Immunobiology 2002, 205:395-406.
6. Carneiro J., Paixão T., Milutinovic D., Sousa J., Leon K., Gardner R., Faro J. Immunological self-tolerance: lessons from mathematical modeling. J. Comput. Appl. Math. 2005, 184:77-100.
7. Celada F. The cellular basis of immunologic memory. Prog. Allergy 1971, 15:223-267.
8. Chapman J.R., Charles P.J., Venables P.J., Thompson P.J., Haslam P.L., Maini R.N., Turner-Warwick M.E. Definition clinical relevance of antibodies to nuclear ribonucleoprotein and other nuclear antigens in patients with cryptogenic fibrosing alveolitis. Am. Rev. Respir. Dis. 1984, 130:439-443.
9. Christensen S.R., Shlomchik M.J. Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors. Semin. Immunol. 2007, 19:11-23.
10. Clynes R., Dumitru C., Ravetch J.V. Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science 1998, 279:1052-1054.
11. Dall'Aglio P.P., Pesci A., Bertorelli G., Brianti E., Scarpa S. Study of immune complexes in bronchoalveolar lavage fluids. Respiration 1988, 54(Suppl. 1):36-41.
12. Davies K.A. Michael Mason Prize Essay 1995. Complement, immune complexes and systemic lupus erythematosus. Br. J. Rheumatol. 1996, 35:5-23.
13. De Boer R.J., Hogeweg P. Memory but no suppression in low-dimensional symmetric idiotypic networks. Bull. Math. Biol. 1988, 51:223-246.
14. De Boer R.J., Hogeweg P. Unreasonable implications of reasonable idiotypic network assumptions. Bull. Math. Biol. 1989, 51:381-408.
15. De Boer R.J., Perelson A.S., Kevrekidis I.G. Immune network behavior I. From stationary states to limit cycle oscillations. Bull. Math. Biol. 1993, 55:745-780.
16. De Boer R.J., Perelson A.S., Kevrekidis I.G. Immune network behavior II. From oscillations to chaos and stationary states. Bull. Math. Biol. 1993, 55:781-816.
17. De Clerck L.S. B lymphocytes and humoral immune responses in rheumatoid arthritis. Clin. Rheumatol. 1995, 14(Suppl. 2):14-18.
18. Ding C. Belimumab, an anti-BLyS human monoclonal antibody for potential treatment of inflammatory autoimmune diseases. Expert Opin. Biol. Ther. 2008, 8:1805-1814.
19. Ermentrout E. Simulating, Analyzing, and Animating Dynamical Systems: A Guide to XPPAUT for Researchers and Students 2002, SIAM, Philadelphia.
20. Feng L., Xia Y., Yoshimura T., Wilson C.B. Modulation of neutrophil influx in glomerulonephritis in the rat with anti-macrophage inflammatory protein-2 (MIP-2) antibody. J. Clin. Invest. 1995, 95:1009-1017.
21. Foley C., Mackey M.C. Dynamic hematological disease: a review. J. Math. Biol. 2009, 58:285-322.
22. Freiesleben De Blasio B., Bak P., Pociot F., Karlsen A.E., Nerup J. Onset of type 1 diabetes: a dynamical instability. Diabetes 1999, 48:1677-1685.
23. Galeazzi M., Morozzi G., Piccini M., Chen J., Bellisai F., Fineschi S., Marcolongo R. Dosage and characterization of circulating DNA: present usage and possible applications in systemic autoimmune disorders. Autoimmun. Rev. 2002, 2:50-55.
24. Gauthier V., Tyler L.N., Mannik M. Blood clearance kinetics and liver uptake of mononucleosomes in mice. J. Immunol. 1996, 156:1151-1156.
25. Grossmayer G.E., Munoz L.E., Gaipl U.S., Franz S., Sheriff A., Voll R.E., Kalden J.R., Herrmann M. Removal of dying cells and systemic lupus erythematosus. Mod. Rheumatol. 2005, 15:383-390.
26. Head M., Meryhew N., Runquist O. Mechanism computer simulation of immune complex formation, opsonization, and clearance. J. Lab. Clin. Med. 1996, 128:61-74.
27. Herbert C., Russo G.G. Polyarteritis nodosa and cutaneous polyarteritis nodosa. Skinmed 2003, 2:277-283.
28. Iwami S., Takeuchi Y., Miura Y., Sasaki T., Kajiwara T. Dynamical properties of autoimmune disease models: tolerance, flare-up, dormancy. J. Theor. Biol. 2007, 246:646-659.
29. Kagami S., Kawakami K., Okada K., Kuroda Y., Morioka T., Shimizu F., Oite T. Mechanism of formation of subepithelial electron-dense deposits in active in situ immune complex glomerulonephritis. Am. J. Pathol. 1990, 136:631-639.
30. Kanwar Y.S., Caulin-Glaser T., Gallo G.R., Lamm M.E. Interaction of immune complexes with glomerular heparan sulfate-proteoglycans. Kidney Int. 1986, 30:842-851.
31. Khadra A., Edelstein-Keshet P.S.L. The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation. J. Theor. Biol. 2009, 256:126-141.
32. Kimberly R.P., Meryhew N.L., Runquist O.A. Mononuclear phagocyte function in SLE. I. Bipartite Fc- and complement-dependent dysfunction. J. Immunol. 1986, 137:91-96.
33. Lorusso L., Hart I.K., Ferrari D., Ngonga G.K., Gasparetto C., Ricevuti G. Autonomic paraneoplastic neurological syndromes. Autoimmun. Rev. 2007, 6:162-168.
34. Luger D., Dayan M., Zinger H., Liu J.P., Mozes E. A peptide based on the complementarity determining region 1 of a human monoclonal autoantibody ameliorates spontaneous and induced lupus manifestations in correlation with cytokine immunomodulation. J. Clin. Immunol. 2004, 24:579-590.
35. Mahaffy J.M., Edelstein-Keshet L. Modeling cyclic waves of circulating T-cells in autoimmune diabetes. SIAM J. Appl. Math. 2007, 67:915-937.
36. Mannik M., Agodoa L.Y., David K.A. Rearrangement of immune complexes in glomeruli leads to persistence and development of electron-dense deposits. J. Exp. Med. 1983, 157:1516-1528.
37. Marée A.F., Komba M., Finegood D.T., Edelstein-Keshet L. A quantitative comparison of rates of phagocytosis and digestion of apoptotic cells by macrophages from normal (BALB/c) and diabetes-prone (NOD) mice. J. Appl. Physiol. 2008, 104:157-169.
38. Marée A.F., Kublik R., Finegood D.T., Edelstein-Keshet L. Modelling the onset of Type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease? Philos. Transact. A Math. Phys. Eng. Sci. 2006, 364:1267-1282.
39. Munoz L.E., Gaipl U.S., Franz S., Sheriff A., Voll R.E., Kalden J.R., Herrmann M. Sle-a disease of clearance deficiency?. Rheumatology (Oxford) 2005, 44:1101-1107.
40. Nash J.T., Taylor P.R., Botto M., Norsworthy P.J., Davies K.A., Walport M.J. Immune complex processing in C1q-deficient mice. Clin. Exp. Immunol. 2001, 123:196-202.
41. Nerup J., Mandrup-Poulsen T., Mølvig J., Helqvist S., Wogensen L., Egeberg J. Mechanisms of pancreatic beta-cell destruction in type I diabetes. Diabetes Care 1988, 11(Suppl. 1):16-23.
42. Nikolic-Paterson D.J., Atkins R.C. The role of macrophages in glomerulonephritis. Nephrol. Dial. Transplant. 2001, 16(Suppl. 5):3-7.
43. Palladino M.A., Bahjat F.R., Theodorakis E.A., Moldawer L.L. Anti-TNF-alpha therapies: the next generation. Nat. Rev. Drug. Discov. 2003, 2:736-746.
44. Perelson A.S., DeLisi C. Receptor clustering on a cell-surface. I. Theory of receptor cross-linking by ligands bearing 2 chemically identical functional groups. Math. Biosci. 1980, 48:71-110.
45. Raptis L., Menard H.A. Quantitation and characterization of plasma DNA in normals and patients with systemic lupus erythematosus. J. Clin. Invest. 1980, 66:1391-1399.
46. Ravetch J.V., Bolland S. IgG Fc receptors. Annu. Rev. Immunol. 2001, 19:275-290.
47. Reefman E., Horst G., Nijk M.T., Limburg P.C., Kallenberg C., Bijl M. Opsonization of late apoptotic cells by systemic lupus erythematosus autoantibodies inhibits their uptake via an Fcgamma receptor-dependent mechanism. Arthritis. Rheum. 2007, 56:3399-3411.
48. Reumaux D., Duthilleul P., Roos D. Pathogenesis of diseases associated with antineutrophil cytoplasm autoantibodies. Hum. Immunol. 2004, 65:1-12.
49. Reynolds A., Rubin J., Clermont G., Day J., Vodovotz Y., Ermentrout G.B. A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation. J. Theor. Biol. 2006, 242:220-236.
50. Salmon J.E., Millard S., Schachter L.A., Arnett F.C., Ginzler E.M., Gourley M.F., Ramsey-Goldman R., Peterson M.G., Kimberly R.P. Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. J. Clin. Invest. 1996, 97:1348-1354.
51. Schiffer L.E., Hussain N., Wang X., Huang W., Sinha J., Ramanujam M., Davidson A. Lowering anti-dsDNA antibodies-what's new?. Lupus 2002, 11:885-894.
52. Schmiedeke T.M., Stöckl F.W., Weber R., Sugisaki Y., Batsford S.R., Vogt A. Histones have high affinity for the glomerular basement membrane. Relevance for immune complex formation in lupus nephritis. J. Exp. Med. 1989, 169:1879-1894.
53. Segal R., Bermas B.L., Dayan M., Kalush F., Shearer G.M., Mozes E. Kinetics of cytokine production in experimental systemic lupus erythematosus: involvement of T helper cell 1/T helper cell 2-type cytokines in disease. J. Immunol. 1997, 15:3009-3016.
54. Segel L.A. Multiple attractors in immunology: theory and experiment. Biophys. Chem. 1998, 72:223-230.
55. Swaak A.J., Groenwold J., Bronsveld W. Predictive value of complement profiles and anti-dsDNA in systemic lupus erythematosus. Ann. Rheum. Dis. 1986, 45:359-366.
56. Tipping P.G., Cornthwaite L.J., Holdsworth S.R. Beta 2 integrin independent neutrophil recruitment and injury in anti-GBM glomerulonephritis in rabbits. Immunol. Cell. Biol. 1994, 72:471-479.
57. Walport M.J. Lupus, DNase, and defective disposal of cellular debris. Nat. Genet. 2000, 25:135-136.