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Volumn 15, Issue 4, 2014, Pages 6925-6940

Protective effect of resveratrol against IL-1β-induced inflammatory response on human osteoarthritic chondrocytes partly via the TLR4/MyD88/NF-κB signaling pathway: An "in vitro study"

Author keywords

Chondrocytes; Inflammation; Interleukin 1 ; Nuclear factor B; Osteoarthritis; Resveratrol; Toll like receptor 4

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; RESVERATROL; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; STILBENE DERIVATIVE;

EID: 84899140678     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15046925     Document Type: Article
Times cited : (88)

References (47)
  • 2
    • 74249106459 scopus 로고    scopus 로고
    • Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes
    • Campo, G.M.; Avenoso, A.; Campo, S.; D'Ascola, A.; Nastasi, G.; Calatroni, A. Molecular size hyaluronan differently modulates toll-like receptor-4 in LPS-induced inflammation in mouse chondrocytes. Biochimie 2010, 92, 204-215.
    • (2010) Biochimie , vol.92 , pp. 204-215
    • Campo, G.M.1    Avenoso, A.2    Campo, S.3    D'Ascola, A.4    Nastasi, G.5    Calatroni, A.6
  • 5
    • 82355169073 scopus 로고    scopus 로고
    • What makes osteoarthritis painful? The evidence for local and central pain processing
    • Sofat, N.; Ejindu, V.; Kiely, P. What makes osteoarthritis painful? The evidence for local and central pain processing. Rheumatology (Oxford) 2011, 50, 2157-2165.
    • (2011) Rheumatology (Oxford) , vol.50 , pp. 2157-2165
    • Sofat, N.1    Ejindu, V.2    Kiely, P.3
  • 7
    • 84899151436 scopus 로고    scopus 로고
    • Osteoarthritis pathogenesis-A complex process that involves the entire joint
    • Man, G.; Mologhianu, G. Osteoarthritis pathogenesis-A complex process that involves the entire joint. J. Med. Life 2014, 7, 37-41.
    • (2014) J. Med. Life , vol.7 , pp. 37-41
    • Man, G.1    Mologhianu, G.2
  • 8
    • 78650307695 scopus 로고    scopus 로고
    • Nutraceuticals: Do they represent a new era in the management of osteoarthritis?-A narrative review from the lessons taken with five products
    • Henrotin, Y.; Lambert, C.; Couchourel, D.; Ripoll, C.; Chiotelli, E. Nutraceuticals: Do they represent a new era in the management of osteoarthritis?-A narrative review from the lessons taken with five products. Osteoarthr. Cartil. 2011, 19, 1-21.
    • (2011) Osteoarthr. Cartil , vol.19 , pp. 1-21
    • Henrotin, Y.1    Lambert, C.2    Couchourel, D.3    Ripoll, C.4    Chiotelli, E.5
  • 9
    • 24744445765 scopus 로고    scopus 로고
    • Biologic approaches to articular cartilage surgery: Future trends
    • Sgaglione, N.A. Biologic approaches to articular cartilage surgery: Future trends. Orthop. Clin. N. Am. 2005, 36, 485-495.
    • (2005) Orthop. Clin. N. Am , vol.36 , pp. 485-495
    • Sgaglione, N.A.1
  • 10
    • 22644441306 scopus 로고    scopus 로고
    • Oxygen and reactive oxygen species in cartilage degradation: Friends or foes?
    • Henrotin, Y.; Kurz, B.; Aigner, T. Oxygen and reactive oxygen species in cartilage degradation: Friends or foes? Osteoarthr. Cartil. 2005, 13, 643-654.
    • (2005) Osteoarthr. Cartil , vol.13 , pp. 643-654
    • Henrotin, Y.1    Kurz, B.2    Aigner, T.3
  • 11
    • 33847191703 scopus 로고    scopus 로고
    • Antioxidant to treat osteoarthritis: Dream or reality
    • Henrotin, Y.; Kurz, B. Antioxidant to treat osteoarthritis: Dream or reality? Curr. Drug Targets 2007, 8, 347-357.
    • (2007) Curr. Drug Targets , vol.8 , pp. 347-357
    • Henrotin, Y.1    Kurz, B.2
  • 12
    • 84887617603 scopus 로고    scopus 로고
    • Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: An in vivo and in vitro study on lubricin expression
    • Musumeci, G.; Trovato, F.M.; Pichler, K.; Weinberg, A.M.; Loreto, C.; Castrogiovanni, P. Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: An in vivo and in vitro study on lubricin expression. J. Nutr. Biochem. 2013, 24, 2064-2075.
    • (2013) J. Nutr. Biochem , vol.24 , pp. 2064-2075
    • Musumeci, G.1    Trovato, F.M.2    Pichler, K.3    Weinberg, A.M.4    Loreto, C.5    Castrogiovanni, P.6
  • 14
    • 33947629255 scopus 로고    scopus 로고
    • Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors
    • Miyake, K. Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin. Immunol. 2007, 19, 3-10.
    • (2007) Semin. Immunol , vol.19 , pp. 3-10
    • Miyake, K.1
  • 15
    • 34447504847 scopus 로고    scopus 로고
    • Toll-like receptors and chondrocytes: The lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7
    • Bobacz, K.; Sunk, I.G.; Hofstaetter, J.G.; Amoyo, L.; Toma, C.D.; Akira, S.; Weichhart, T.; Saemann, M.; Smolen, J.S. Toll-like receptors and chondrocytes: The lipopolysaccharide-induced decrease in cartilage matrix synthesis is dependent on the presence of toll-like receptor 4 and antagonized by bone morphogenetic protein 7. Arthritis Rheumatol. 2007, 56, 1880-1893.
    • (2007) Arthritis Rheumatol , vol.56 , pp. 1880-1893
    • Bobacz, K.1    Sunk, I.G.2    Hofstaetter, J.G.3    Amoyo, L.4    Toma, C.D.5    Akira, S.6    Weichhart, T.7    Saemann, M.8    Smolen, J.S.9
  • 16
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
    • Hoshino, K.; Takeuchi, O.; Kawai, T.; Sanjo, H.; Ogawa, T.; Takeda, Y.; Takeda, K.; Akira, S. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product. J. Immunol. 1999, 162, 3749-3752.
    • (1999) J. Immunol , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6    Takeda, K.7    Akira, S.8
  • 17
    • 34249329607 scopus 로고    scopus 로고
    • Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages
    • Loniewski, K.J.; Patial, S.; Parameswaran, N. Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages. Mol. Immunol. 2007, 44, 3715-3723.
    • (2007) Mol. Immunol , vol.44 , pp. 3715-3723
    • Loniewski, K.J.1    Patial, S.2    Parameswaran, N.3
  • 20
    • 33745728903 scopus 로고    scopus 로고
    • Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity
    • Kundu, J.K.; Shin, Y.K.; Kim, S.H.; Surh, Y.J. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis 2006, 27, 1465-1474.
    • (2006) Carcinogenesis , vol.27 , pp. 1465-1474
    • Kundu, J.K.1    Shin, Y.K.2    Kim, S.H.3    Surh, Y.J.4
  • 21
    • 51849141393 scopus 로고    scopus 로고
    • The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production
    • Dave, M.; Attur, M.; Palmer, G.; Al-Mussawir, H.E.; Kennish, L.; Patel, J.; Abramson, S.B. The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production. Arthritis Rheumatol. 2008, 58, 2786-2797.
    • (2008) Arthritis Rheumatol , vol.58 , pp. 2786-2797
    • Dave, M.1    Attur, M.2    Palmer, G.3    Al-Mussawir, H.E.4    Kennish, L.5    Patel, J.6    Abramson, S.B.7
  • 22
    • 76449099412 scopus 로고    scopus 로고
    • Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: Inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis
    • Csaki, C.; Mobasheri, A.; Shakibaei, M. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: Inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res. Ther. 2009, 11, R165.
    • (2009) Arthritis Res. Ther , vol.11
    • Csaki, C.1    Mobasheri, A.2    Shakibaei, M.3
  • 23
    • 55949132020 scopus 로고    scopus 로고
    • Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: Potential for use as a novel nutraceutical for the treatment of osteoarthritis
    • Shakibaei, M.; Csaki, C.; Nebrich, S.; Mobasheri, A. Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: Potential for use as a novel nutraceutical for the treatment of osteoarthritis. Biochem. Pharmacol. 2008, 76, 1426-1439.
    • (2008) Biochem. Pharmacol , vol.76 , pp. 1426-1439
    • Shakibaei, M.1    Csaki, C.2    Nebrich, S.3    Mobasheri, A.4
  • 24
    • 84887368046 scopus 로고    scopus 로고
    • Resveratrol inhibits nitric oxide-induced apoptosis via the NF-kappa B pathway in rabbit articular chondrocytes
    • Eo, S.H.; Cho, H.; Kim, S.J. Resveratrol inhibits nitric oxide-induced apoptosis via the NF-kappa B pathway in rabbit articular chondrocytes. Biomol. Ther. (Seoul) 2013, 21, 364-370.
    • (2013) Biomol. Ther. (Seoul) , vol.21 , pp. 364-370
    • Eo, S.H.1    Cho, H.2    Kim, S.J.3
  • 25
    • 37849041521 scopus 로고    scopus 로고
    • Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro
    • Csaki, C.; Keshishzadeh, N.; Fischer, K.; Shakibaei, M. Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro. Biochem. Pharmacol. 2008, 75, 677-687.
    • (2008) Biochem. Pharmacol , vol.75 , pp. 677-687
    • Csaki, C.1    Keshishzadeh, N.2    Fischer, K.3    Shakibaei, M.4
  • 26
    • 34247880271 scopus 로고    scopus 로고
    • Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro
    • Shakibaei, M.; John, T.; Seifarth, C.; Mobasheri, A. Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro. Ann. N. Y. Acad. Sci. 2007, 1095, 554-563.
    • (2007) Ann. N. Y. Acad. Sci , vol.1095 , pp. 554-563
    • Shakibaei, M.1    John, T.2    Seifarth, C.3    Mobasheri, A.4
  • 29
    • 84862663704 scopus 로고    scopus 로고
    • Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells
    • Im, H.J.; Li, X.; Chen, D.; Yan, D.; Kim, J.; Ellman, M.B.; Stein, G.S.; Cole, B.; Kc, R.; Cs-Szabo, G.; et al. Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells. J. Cell Physiol. 2012, 227, 3488-3497.
    • (2012) J. Cell Physiol , vol.227 , pp. 3488-3497
    • Im, H.J.1    Li, X.2    Chen, D.3    Yan, D.4    Kim, J.5    Ellman, M.B.6    Stein, G.S.7    Cole, B.8    Kc, R.9    Cs-Szabo, G.10
  • 30
    • 0034660659 scopus 로고    scopus 로고
    • Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: Potential role of reactive oxygen intermediates and lipid peroxidation
    • Manna, S.K.; Mukhopadhyay, A.; Aggarwal, B.B. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J. Immunol. 2000, 164, 6509-6519.
    • (2000) J. Immunol , vol.164 , pp. 6509-6519
    • Manna, S.K.1    Mukhopadhyay, A.2    Aggarwal, B.B.3
  • 31
    • 84855559736 scopus 로고    scopus 로고
    • Resveratrol inhibits interleukin 1beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappaB activity
    • Lei, M.; Wang, J.G.; Xiao, D.M.; Fan, M.; Wang, D.P.; Xiong, J.Y.; Chen, Y.; Ding, Y.; Liu, S.L. Resveratrol inhibits interleukin 1beta-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-kappaB activity. Eur. J. Pharmacol. 2012, 674, 73-79.
    • (2012) Eur. J. Pharmacol , vol.674 , pp. 73-79
    • Lei, M.1    Wang, J.G.2    Xiao, D.M.3    Fan, M.4    Wang, D.P.5    Xiong, J.Y.6    Chen, Y.7    Ding, Y.8    Liu, S.L.9
  • 32
    • 23844478190 scopus 로고    scopus 로고
    • Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: Molecular targets are TBK1 and RIP1 in TRIF complex
    • Youn, H.S.; Lee, J.Y.; Fitzgerald, K.A.; Young, H.A.; Akira, S.; Hwang, D.H. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: Molecular targets are TBK1 and RIP1 in TRIF complex. J. Immunol. 2005, 175, 3339-3346.
    • (2005) J. Immunol , vol.175 , pp. 3339-3346
    • Youn, H.S.1    Lee, J.Y.2    Fitzgerald, K.A.3    Young, H.A.4    Akira, S.5    Hwang, D.H.6
  • 33
    • 84863250768 scopus 로고    scopus 로고
    • Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-kappaB signaling pathway
    • Zhang, C.; Lin, G.; Wan, W.; Li, X.; Zeng, B.; Yang, B.; Huang, C. Resveratrol, a polyphenol phytoalexin, protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-kappaB signaling pathway. Int. J. Mol. Med. 2012, 29, 557-563.
    • (2012) Int. J. Mol. Med , vol.29 , pp. 557-563
    • Zhang, C.1    Lin, G.2    Wan, W.3    Li, X.4    Zeng, B.5    Yang, B.6    Huang, C.7
  • 34
    • 0033000873 scopus 로고    scopus 로고
    • Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes
    • Blanco, F.J.; Guitian, R.; Moreno, J.; de Toro, F.J.; Galdo, F. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J. Rheumatol. 1999, 26, 1366-1373.
    • (1999) J. Rheumatol , vol.26 , pp. 1366-1373
    • Blanco, F.J.1    Guitian, R.2    Moreno, J.3    de Toro, F.J.4    Galdo, F.5
  • 35
    • 0031658981 scopus 로고    scopus 로고
    • Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis
    • Hashimoto, S.; Ochs, R.L.; Komiya, S.; Lotz, M. Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheumatol. 1998, 41, 1632-1638.
    • (1998) Arthritis Rheumatol , vol.41 , pp. 1632-1638
    • Hashimoto, S.1    Ochs, R.L.2    Komiya, S.3    Lotz, M.4
  • 36
    • 0033638543 scopus 로고    scopus 로고
    • Apoptosis in normal and osteoarthritic human articular cartilage
    • Heraud, F.; Heraud, A.; Harmand, M.F. Apoptosis in normal and osteoarthritic human articular cartilage. Ann. Rheum. Dis. 2000, 59, 959-965.
    • (2000) Ann. Rheum. Dis , vol.59 , pp. 959-965
    • Heraud, F.1    Heraud, A.2    Harmand, M.F.3
  • 37
    • 0036675540 scopus 로고    scopus 로고
    • Apoptosis and cellular vitality: Issues in osteoarthritic cartilage degeneration
    • Aigner, T.; Kim, H.A. Apoptosis and cellular vitality: Issues in osteoarthritic cartilage degeneration. Arthritis Rheumatol. 2002, 46, 1986-1996.
    • (2002) Arthritis Rheumatol , vol.46 , pp. 1986-1996
    • Aigner, T.1    Kim, H.A.2
  • 38
    • 77952921830 scopus 로고    scopus 로고
    • Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line
    • Iacono, A.; Gomez, R.; Sperry, J.; Conde, J.; Bianco, G.; Meli, R.; Gomez-Reino, J.J.; Smith, A.B., 3rd; Gualillo, O. Effect of oleocanthal and its derivatives on inflammatory response induced by lipopolysaccharide in a murine chondrocyte cell line. Arthritis Rheumatol. 2010, 62, 1675-1682.
    • (2010) Arthritis Rheumatol , vol.62 , pp. 1675-1682
    • Iacono, A.1    Gomez, R.2    Sperry, J.3    Conde, J.4    Bianco, G.5    Meli, R.6    Gomez-Reino, J.J.7    Smith III, A.B.8    Gualillo, O.9
  • 39
    • 77958001297 scopus 로고    scopus 로고
    • Sirtuins: Common targets in aging and in neurodegeneration
    • De Oliveira, R.M.; Pais, T.F.; Outeiro, T.F. Sirtuins: Common targets in aging and in neurodegeneration. Curr. Drug Targets 2010, 11, 1270-1280.
    • (2010) Curr. Drug Targets , vol.11 , pp. 1270-1280
    • De Oliveira, R.M.1    Pais, T.F.2    Outeiro, T.F.3
  • 40
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira, S.; Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4, 499-511.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 41
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira, S.; Takeda, K.; Kaisho, T. Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat. Immunol. 2001, 2, 675-680.
    • (2001) Nat. Immunol , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 42
    • 0042744823 scopus 로고    scopus 로고
    • Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells
    • Estrov, Z.; Shishodia, S.; Faderl, S.; Harris, D.; Van, Q.; Kantarjian, H.M.; Talpazm, M.; Aggarwal, B.B. Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 2003, 102, 987-995.
    • (2003) Blood , vol.102 , pp. 987-995
    • Estrov, Z.1    Shishodia, S.2    Faderl, S.3    Harris, D.4    Van, Q.5    Kantarjian, H.M.6    Talpazm, M.7    Aggarwal, B.B.8
  • 43
    • 84878186016 scopus 로고    scopus 로고
    • EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee
    • Chen, Y.J.; Tsai, K.S.; Chiu, C.Y.; Yang, T.H.; Lin, T.H.; Fu, W.M.; Chen, C.F.; Yang, R.S.; Liu, S.H. EGb761 inhibits inflammatory responses in human chondrocytes and shows chondroprotection in osteoarthritic rat knee. J. Orthop. Res. 2013, 31, 1032-1038.
    • (2013) J. Orthop. Res , vol.31 , pp. 1032-1038
    • Chen, Y.J.1    Tsai, K.S.2    Chiu, C.Y.3    Yang, T.H.4    Lin, T.H.5    Fu, W.M.6    Chen, C.F.7    Yang, R.S.8    Liu, S.H.9
  • 44
    • 0035866404 scopus 로고    scopus 로고
    • Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase
    • She, Q.B.; Bode, A.M.; Ma, W.Y.; Chen, N.Y.; Dong, Z. Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res. 2001, 61, 1604-1610.
    • (2001) Cancer Res , vol.61 , pp. 1604-1610
    • She, Q.B.1    Bode, A.M.2    Ma, W.Y.3    Chen, N.Y.4    Dong, Z.5
  • 45
    • 18644376728 scopus 로고    scopus 로고
    • TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: A critical role of IFN-beta as a decision maker
    • Jung, D.Y.; Lee, H.; Jung, B.Y.; Ock, J.; Lee, M.S.; Lee, W.H.; Suk, K. TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: A critical role of IFN-beta as a decision maker. J. Immunol. 2005, 174, 6467-6476.
    • (2005) J. Immunol , vol.174 , pp. 6467-6476
    • Jung, D.Y.1    Lee, H.2    Jung, B.Y.3    Ock, J.4    Lee, M.S.5    Lee, W.H.6    Suk, K.7
  • 46
    • 76849105159 scopus 로고    scopus 로고
    • Protective effect of resveratrol against LPS-induced extracellular lipoperoxidation in AR42J cells partly via a Myd88-dependent signaling pathway
    • Sebai, H.; Ristorcelli, E.; Sbarra, V.; Hovsepian, S.; Fayet, G.; Aouani, E.; Lombardo, D. Protective effect of resveratrol against LPS-induced extracellular lipoperoxidation in AR42J cells partly via a Myd88-dependent signaling pathway. Arch. Biochem. Biophys. 2010, 495, 56-61.
    • (2010) Arch. Biochem. Biophys , vol.495 , pp. 56-61
    • Sebai, H.1    Ristorcelli, E.2    Sbarra, V.3    Hovsepian, S.4    Fayet, G.5    Aouani, E.6    Lombardo, D.7
  • 47
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak, K.J.; Schmittgen, T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2


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