Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver

Hepatology

Volumn 56, Issue 4, 2012, Pages 1510-1520

  Verma, Suman ^a   Tachtatzis, Phaedra ^a   Penrhyn Lowe, Sue ^b   Scarpini, Cinzia ^b   Jurk, Diana ^c   Von Zglinicki, Thomas ^c   Coleman, Nick ^b   Alexander, Graeme J M ^a  

^a CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CHOLANGIOCYTE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; KUPFFER CELL; LIVER CELL; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; REPERFUSION INJURY; SCHOOL CHILD; SOUTHERN BLOTTING; STEATOSIS; STELLATE CELL; TELOMERE;

ADOLESCENT; ADULT; AGED; AGING; BILE DUCTS; CELL AGING; CELLS, CULTURED; CHILD, PRESCHOOL; FEMALE; HEPATOCYTES; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KUPFFER CELLS; LIVER; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SAMPLING STUDIES; SENSITIVITY AND SPECIFICITY; TELOMERE; TELOMERE SHORTENING; YOUNG ADULT;

EID: 84867206636     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.25787     Document Type: Article

References (49)

1. Hoare M, Das T, Alexander G. Ageing, telomeres, senescence, and liver injury. J Hepatol 2010; 53: 950-961.
2. Schmucker DL. Age-related changes in liver structure and function: implications for disease? Exp Gerontol 2005; 40: 650-659.
3. Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet 1997; 349: 825-832.
4. Younossi ZM, Stepanova M. Hepatitis C virus infection, age, and Hispanic ethnicity increase mortality from liver cancer in the United States. Clin Gastroenterol Hepatol 2010; 8: 718-723.
5. Bellentani S, Scaglioni F, Marino M, Bedogni G. Epidemiology of non-alcoholic fatty liver disease. Dig Dis 2010; 28: 155-161.
6. Keswani RN, Ahmed A, Keeffe EB. Older age and liver transplantation: a review. Liver Transpl 2004; 10: 957-967.
7. Regev A, Schiff ER. Liver disease in the elderly. Gastroenterol Clin North Am 2001; 30: 547-563.
8. Dhiman RK, Jain S, Maheshwari U, Bhalla A, Sharma N, Ahluwalia J, et al. Early indicators of prognosis in fulminant hepatic failure: an assessment of the model for end-stage liver disease (MELD) and King's College Hospital criteria. Liver Transpl 2007; 13: 814-821.
9. Forbes A, Williams R. Increasing age-an important adverse prognostic factor in hepatitis A virus infection. J R Coll Physicians Lond 1988; 22: 237-239.
10. Forbes A, Williams R. Changing epidemiology and clinical aspects of hepatitis A. Br Med Bull 1990; 46: 303-318.
11. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci 2002; 27: 339-344.
12. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345: 458-460.
13. Hastie ND, Dempster M, Dunlop MG, Thompson AM, Green DK, Allshire RC. Telomere reduction in human colorectal carcinoma and with ageing. Nature 1990; 346: 866-868.
14. Lindsey J, McGill NI, Lindsey LA, Green DK, Cooke HJ. In vivo loss of telomeric repeats with age in humans. Mutat Res 1991; 256: 45-48.
15. Allsopp RC, Chang E, Kashefi-Aazam M, Rogaev EI, Piatyszek MA, Shay JW, et al. Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res 1995; 220: 194-200.
16. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB, et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A 1992; 89: 10114-10118.
17. Njajou OT, Cawthon RM, Damcott CM, Wu SH, Ott S, Garant MJ, et al. Telomere length is paternally inherited and is associated with parental lifespan. Proc Natl Acad Sci U S A 2007; 104: 12135-12139.
18. von Figura G, Hartmann D, Song Z, Rudolph KL. Role of telomere dysfunction in aging and its detection by biomarkers. J Mol Med 2009; 87: 1165-1171.
19. Kimura M, Hjelmborg JV, Gardner JP, Bathum L, Brimacombe M, Lu X, et al. Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol 2008; 167: 799-806.
20. Aviv A. Chronology versus biology: telomeres, essential hypertension, and vascular aging. Hypertension 2002; 40: 229-232.
21. Ferlicot S, Youssef N, Feneux D, Delhommeau F, Paradis V, Bedossa P. Measurement of telomere length on tissue sections using quantitative fluorescence in situ hybridization (Q-FISH). J Pathol 2003; 200: 661-666.
22. O'sullivan JN, Finley JC, Risques RA, Shen WT, Gollahon KA, Rabinovitch PS. Quantitative fluorescence in situ hybridization (QFISH) of telomere lengths in tissue and cells. Curr Protoc Cytom 2005; Chapter 12: Unit 12 16.
23. Nakajima T, Katagishi T, Moriguchi M, Sekoguchi S, Nishikawa T, Takashima H, et al. Tumor size-independence of telomere length indicates an aggressive feature of HCC. Biochemical and biophysical research communications 2004; 325: 1131-1135.
24. Wiemann SU, Satyanarayana A, Tsahuridu M, Tillmann HL, Zender L, Klempnauer J, et al. Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J 2002; 16: 935-942.
25. Takubo K, Nakamura K, Izumiyama N, Furugori E, Sawabe M, Arai T, et al. Telomere shortening with aging in human liver. J Gerontol A Biol Sci Med Sci 2000; 55: B533-B536.
26. Aikata H, Takaishi H, Kawakami Y, Takahashi S, Kitamoto M, Nakanishi T, et al. Telomere reduction in human liver tissues with age and chronic inflammation. Exp Cell Res 2000; 256: 578-582.
27. Ogawa K, Minase T, Yokoyama S, Onoe T. An ultrastructural study of peroxidatic and phagocytic activities of two types of sinusoidal lining cells in rat liver. Tohoku J Exp Med 1973; 111: 253-259.
28. Rampazzo E, Bertorelle R, Serra L, Terrin L, Candiotto C, Pucciarelli S, et al. Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers. Br J Cancer 2010; 102: 1300-1305.
29. Saini N, Srinivasan R, Chawla Y, Sharma S, Chakraborti A, Rajwanshi A. Telomerase activity, telomere length and human telomerase reverse transcriptase expression in hepatocellular carcinoma is independent of hepatitis virus status. Liver Int 2009; 29: 1162-1170.
30. Zhang Y, Shen J, Ming W, Lee YP, Santella RM. Telomere length in hepatocellular carcinoma and paired adjacent non-tumor tissues by quantitative PCR. Cancer Invest 2007; 25: 668-677.
31. Nakajima T, Moriguchi M, Katagishi T, Sekoguchi S, Nishikawa T, Takashima H, et al. Premature telomere shortening and impaired regenerative response in hepatocytes of individuals with NAFLD. Liver Int 2006; 26: 23-31.
32. Saner FH, Treckmann J, Pratschke J, Arbogast H, Rahmel A, Vester U, et al. Early renal failure after domino liver transplantation using organs from donors with primary hyperoxaluria type 1. Transplantation 2010; 90: 782-785.
33. Bastani B, Mistry BM, Nahass GT, Joh J, Dundoo G, Solomon H. Oxalate kinetics and reversal of the complications after orthotopic liver transplantation in a patient with primary hyperoxalosis type 1 awaiting renal transplantation. Am J Nephrol 1999; 19: 64-69.
34. Casas-Melley AT, Thomas PG, Krueger LJ, Falkenstein KP, Flynn LM, Conley SB, et al. Domino as a bridge to definitive liver transplantation in a neonate. Pediatr Transplant 2002; 6: 249-254.
35. Donckier V, El Nakadi I, Closset J, Ickx B, Louis H, Le Moine O, et al. Domino hepatic transplantation using the liver from a patient with primary hyperoxaluria. Transplantation 2001; 71: 1346-1348.
36. Farese S, Trost N, Candinas D, Huynh-Do U. Early renal failure after domino hepatic transplantation using the liver from a compound heterozygous patient with primary hyperoxaluria. Nephrol Dial Transplant 2005; 20: 2557-2560.
37. Franchello A, Paraluppi G, Romagnoli R, Petrarulo M, Vitale C, Pacitti A, et al. Severe course of primary hyperoxaluria and renal failure after domino hepatic transplantation. Am J Transplant 2005; 5: 2324-2327.
38. Aziz S, Callen PW, Vincenti F, Hirose R. Rapidly developing nephrocalcinosis in a patient with end-stage liver disease who received a domino liver transplant from a patient with known congenital oxalosis. J Ultrasound Med 2005; 24: 1449-1452.
39. Theise ND, Saxena R, Portmann BC, Thung SN, Yee H, Chiriboga L, et al. The canals of Hering and hepatic stem cells in humans. HEPATOLOGY 1999; 30: 1425-1433.
40. Russo FP, Alison MR, Bigger BW, Amofah E, Florou A, Amin F, et al. The bone marrow functionally contributes to liver fibrosis. Gastroenterology 2006: 1807-1821.
41. Baba S, Fujii H, Hirose T, Yasuchika K, Azuma H, Hoppo T, et al. Commitment of bone marrow cells to hepatic stellate cells in mouse. J Hepatol 2004: 255-260.
42. Miyata E, Masuya M, Yoshida S, Nakamura S, Kato K, Sugimoto Y, et al. Hematopoietic origin of hepatic stellate cells in the adult liver. Blood 2008; 111: 2427-2435.
43. Wynne H, Cope LH, Mutch E, Rawlins MD, Woodhouse KW, James OF. The effect of age upon liver volume and apparent liver blood flow in healthy man. HEPATOLOGY 1989; 9: 297-301.
44. Zoll M IT, Abbati S, Bianchi GP, Marchesini G, Pisi E. Portal blood velocity and flow in ageing man. Gerontology 1989; 35: 61-65.
45. Popper H, Schaffner F, eds. Aging and the Liver. Orlando, FL: Grune and Stratton; 1986.
46. Gale RP, Sparkes RS, Golde DW. Bone marrow origin of hepatic macrophages (Kupffer cells) in humans. Science 1978; 201: 937-938.
47. Crofton RW, Diesselhoff-den Dulk MM, van Furth R. The origin, kinetics, and characteristics of the Kupffer cells in the normal steady state. J Exp Med 1978; 148: 1-17.
48. Heil MF, Dingman AD, Garvey JS. Antigen handling in ageing. III. Age-related changes in antigen handling by liver parenchymal and nonparenchymal cells. Mech Ageing Dev 1984; 26: 327-340.
49. Takeishi T, Hirano K, Kobayashi T, Hasegawa G, Hatakeyama K, Naito M. The role of Kupffer cells in liver regeneration. Arch Histol Cytol 1999; 62: 413-422.