Cytotoxicity and morphological transforming potential of cobalt nanoparticles, microparticles and ions in Balb/3T3 mouse fibroblasts: An in vitro model

Nanotoxicology

Volumn 8, Issue 4, 2014, Pages 455-464

  Sabbioni, Enrico ^a   Fortaner, Salvador ^b   Farina, Massimo ^c   Del Torchio, Riccardo ^d   Olivato, Iolanda ^a   Petrarca, Claudia ^e   Bernardini, Giovanni ^f,g   Mariani Costantini, Renato ^e   Perconti, Silvia ^e   Di Giampaolo, Luca ^e   Gornati, Rosalba ^f,g   Di Gioacchino, Mario ^e  

^a European Center for the Sustainable Impact of Nanotechnologies   (Italy)

^b JOINT RESEARCH CENTRE   (Italy)

^c Phi Science srl Chemical and Safety Consulting   (Italy)

^d Ext EC Europe   (Italy)

^e UNIVERSITY OF CHIETI   (Italy)

^f UNIVERSITY OF INSUBRIA   (Italy)

^g POLITECNICO DI MILANO   (Italy)

Author keywords

Balb 3T3; Cytotoxicity and morphological transformation; Essential elements; Lipid peroxidation; ROS

Indexed keywords

ASCORBIC ACID; COBALT; COBALT MICROPARTICLE; COBALT NANOPARTICLE; COPPER; MAGNESIUM; NANOPARTICLE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ARTICLE; BIOAVAILABILITY; CELL NUCLEUS; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DNA ADDUCT; FIBROBLAST; IN VITRO STUDY; INTERNALIZATION; INTRACELLULAR TRANSPORT; LIPID PEROXIDATION; MITOCHONDRION; MORPHOLOGY; MOUSE; NANOTOXICOLOGY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BALB 3T3 CELLS; CELL SURVIVAL; COBALT; FIBROBLASTS; METAL NANOPARTICLES; MICE; MICROSPHERES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84890390637     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2013.796538     Document Type: Article

References (51)

1. Beer C, Foldbjerg R, Hayashi Y, Sutherland DS, Autrup H. Toxicity of silver nanoparticles - nanoparticle or silver ion? Toxicol Lett 2012. 208:286-292
2. Bernardini G, Cattaneo AG, Sabbioni E, Di Gioacchino M, Chiriva-Internati M, Gornati R. 2011. Toxicology of engineered metal nanoparticles. In: Sahu SC and Casciano D, editors. Handbook of system toxicology vol II. Chichester: Wiley & Sons Ltd. 729- 742
3. Bouchard LS, Anwar MS, Liu GL, Hann B, Xie ZH, Gray J W, et al. 2009. Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles. Proc Natl Acad Sci USA 106:4085-4089
4. Brubacher D, Moser U, Jordan P. 2000. Vitamin C concentrations in plasma as a function of intake: A meta-Analysis. Int J Vitam Nutr Res 70:226-237
5. Brunner TJ, Wick P, Manser P, Spohn P, Grass RN, Limbach LK, et al. 2006. In vitro cytotoxicity of oxide nanoparticles: Comparison to asbestos, silica, and the effect of particle solubility. Environ Sci Technol 40:4374-4381
6. Bucher JR, Hailey JR, Roycroft JR, Haseman JK, Sills RC, Grumbein SL, et al. 1999. Inhalation toxicity and carcinogenicity studies of cobalt sulfate. Toxicol Sci 49:56-67
7. Cattaneo AG, Gornati R, Sabbioni E, Chiriva-Internati M, Cobos E, Jenkins MR, et al. 2010. Nanotechnology and human health: Risks and benefits. J Appl Toxicol 30:730-744
8. Chou NH, Ross PN, Bell AT, Tilley TD. 2011. Comparison of cobaltbased nanoparticles as electrocatalysts for water oxidation. ChemSusChem 4:1566-1569
9. Colognato R, Bonelli A, Ponti J, Farina M, Bergamaschi E, Sabbioni E, et al. 2008. Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro. Mutagenesis 23:377-382
10. Combes R, Balls M, Curren R, Fischbach M, Fusenig N, Kirkland D, et al. 1999. Cell transformation assays as predictors of human carcinogenicity. The report and recommendations of ECVAM Workshop 39. ATLA 27:745-767
11. Di Gioacchino M, Verna N, Gornati R, Sabbioni E, Bernardini G. 2009. Metal nanoparticle health risk assessment. In: Sahu SC, Casciano DA, editors. Nanotoxicity. Chichester: John Wiley & Sons Ltd. Chapter 24, pp 519-541
12. EURL ECVAM (2012), Recommendation of 14.03.12 on three Cell Transformation Assays (CTA) Using Syrian Hamster Embryo Cells (SHE) and the BALB/c 3T3 Mouse Fibroblast Cell Line for in vitro Carcinogenicity Testing
13. Garrick MD, Dolan KG, Horbinski C, Ghio AJ, Higgins D, Porubcin M, et al. 2003. DMT1: A mammalian transporter for multiple metals. Biometals 16:41-54
14. Hartung T, Sabbioni E. 2011. Alternative in vitro assays in nanomaterial toxicology. Wiley Interdiscip Rev Nanomed Nanobiotechnol 3:545-573
15. Henkler F, Brinkmann J, Luch A. 2010. The role of oxidative stress in carcinogenesis induced by metals and xenobiotics. Cancers 2:376- 396
16. Iablokov V, Beaumont SK, Alayoglu S, Pushkarev VV, Specht C, Gao J, et al. 2012. Size-controlled model co nanoparticle catalysts for CO2 hydrogenation: Synthesis, characterization, and catalytic reactions. Nano Lett 12:3091-3096
17. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. 2006. Cobalt in hard metals and cobalt sulfate, gallium arsenide, indium phosphide and vanadium pentoxide. IARC Monogr Eval Carcinog Risks Hum 86:1-294
18. Jiang H, Liu F, Yang H, Li Y. 2012. Effects of cobalt nanoparticles on human T cells in vitro. Biol Trace Elem Res 146:23-29
19. Kerckaert GA, LeBoeuf RA, Isfort RJ. 1996. Use of the Syrian hamster embryo cell transformation assay for determining the carcinogenic potential of heavy metal compounds. Fundam Appl Toxicol 34:67-72
20. Klostergaard J, Seeney CE. 2012. Magnetic nanovectors for drug delivery. Nanomedicine 8:S37-S50
21. Krug HF, Wick P. 2011. Nanotoxicology: An interdisciplinary challenge. Angew Chem Int Ed Engl 50:1260-1278
22. Li YF, Chen C, Qu Y, GaoY Li B, Zhao Y, et al. 2008. Metallomics, elementomics, and analytical techniques. Pure Appl Chem 80: 2577-2594
23. Lison D, Carbonnelle P, Mollo L, Lauwerys R, Fubini B. 1995. Physicochemical mechanism of the interaction between cobalt metal and carbide particles to generate toxic activated oxygen species. Chem Res Toxicol 8:600-606
24. Lison D, De Boeck M, Verougstraete V, Kirsch-Volders M. 2001. Update on the genotoxicity and carcinogenicity of cobalt compounds. Occup Environ Med 58:619-625
25. Lison D, Lauwerys R, Demedts M, Nemery B. 1996. Experimental research into the pathogenesis of cobalt/hard metal lung disease. Eur Respir J 9:1024-1028
26. Lubick N. 2008. Nanosilver toxicity: Ions, nanoparticles or both? Environ Sci Technol 42:8617
27. Mazzotti F, Sabbioni E, Ghiani M, Cocco B, Ceccatelli R, Fortaner S. 2001. In vitro assessment of cytotoxicity and carcinogenic potential of chemicals: Evaluation of the cytotoxicity induced by 58 metal forms in the BALB/3T3 cell line. Altern Lab Anim 29: 601-611
28. Méplan C, Richard MJ, Hinaut P. 2000. Metalloregulation of the tumor suppression protein p53: Zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells. Oncogene 19:5227-5236
29. Mo Y, Zhu X, Hu X, Tollerud DJ, Zhang Q. 2008. Cytokine and NO release from peripheral blood neutrophils after exposure to metal nanoparticles: In vitro and ex vivo studies. Nanotoxicology 2:79-87
30. Monteiller C, Tran L, MacNee W, Faux S, Jones A, Miller B, et al. 2007. The pro-inflammatory effects of low-Toxicity low solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: The role of surface area. Occup Environ Med 64:609-615
31. Moulis JM. 2010. Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals. Biometals 23:877-896
32. Nelo M, Sowpati AK, Palukuru VK, Juuti J, Jantunen H. 2010. Formulation of screen printable cobalt nanoparticle ink for high frequency applications. Prog electromagnetic res 110:253-266
33. Papageorgiou I, Brown C, Schins R, Singh S, Newson R, Davis S, et al. 2007. The effect of nano- And micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitro. Biomaterials 28:2946-2958
34. Papis E, Gornati R, Prati M, Ponti J, Sabbioni E, Bernardini G. 2007. Gene expression in nanotoxicology research: Analysis by differential display in BALB3T3 fibroblasts exposed to cobalt particles and ions. Toxicol Lett 170:185-192
35. Papis E, Rossi F, Raspanti M, Dalle-Donne I, Colombo G, Milzani A, et al. 2009. Engineered cobalt oxide nanoparticles readily enter cells. Toxicol Lett 189:253-259
36. Park EJ, Yi J, Kim Y, Choi K, Park K. 2010. Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism. Toxicol In Vitro 24:872-878
37. Petrarca C, Perrone A, Verna N, Verginelli F, Ponti J, Sabbioni E, et al. 2006. Cobalt nano-particles modulate cytokine in vitro release by human mononuclear cells mimicking autoimmune disease. Int J Immunopathol Pharmacol 19:11-14
38. Pisanic TR, Blackwell JD, Shubayev VI, Fiñones RR, Jin S. 2007. Nanotoxicity of iron oxide nanoparticle internalization in growing neurons. Biomaterials 28:2572-2581
39. Ponti J, Sabbioni E, Munaro B, Broggi F, Marmorato P, Franchini F, et al. 2009. Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride: An in vitro study in Balb/3T3 mouse fibroblasts. Mutagenesis 24:439-445
40. Puntes VF, Gorostiza P, Aruguete DM, Bastus NG, Alivisatos AP. 2004. Collective behaviour in two-dimensional cobalt nanoparticle assemblies observed by magnetic force microscopy. Nate Mat 3:263-268
41. Puntes VF, Krishnan KM, Alivisatos AP. 2001. Colloidal nanocrystal shape and size control: The case of cobalt. Science 291:2115-2117
42. Rahman I, Kode A, Biswas SK. 2007. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc 1:3159-3165
43. Sabbioni E, Fortaner S, Farina M, Del Torchio R, Petrarca C, Bernardini G, et al. 2012. Interaction with culture medium components, cellular uptake and intracellular distribution of cobalt nanoparticles, microparticles and ions in Balb/3T3 mouse fibroblasts. Nanotoxicology; Epub ahead of print
44. Sabbioni E, Pietra R, Minoia C, Edel J. 1993. Application of nuclear, radiochemical and spectrochemical techniques in metal toxicology. J Trace Micro Tech 11:217-233
45. Sayes CM, Gobin AM, Ausman KD, Mendez J, West JL, Colvin VL. 2005. Nano-C60 cytotoxicity is due to lipid peroxidation. Biomaterials 36:7587-7595
46. Simonsen LO, Harbak H, Bennekou P. 2012. Cobalt metabolism and toxicology-A brief update. Sci Total Environ 432:210-215
47. Studer AM, Limbach LK, Van Duc L, Krumeich F, Athanassiou EK, Gerber LC, et al. 2010. Nanoparticle cytotoxicity depends on intracellular solubility: Comparison of stabilized copper metal and degradable copper oxide nanoparticles. Toxicol Lett 197:169-174
48. Tanaka N, Bohnenberger S, Kunkelmann T, Munaro B, Ponti J, Poth A, et al. 2011. Prevalidation study of the BALB/c 3T3 cell transformation assay for assessment of carcinogenic potential of chemicals. Mutat Res 744:20-29
49. Valko M, Morris H, Cronin MTD. 2005. Metals, toxicity and oxidative stress. Curr Med Chem 12:1161-1208
50. Witkiewicz-Kucharczyk A, Bal W. 2006. Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis. Toxicol Lett 162:29-42
51. Zhao F, Zhao Y, Liu Y, Chang X, Chen C, Zhao Y. 2011. Cellular uptake, intracellular trafficking, and cytotoxicity of nanomaterials. Small 23:1322-1337