Xenobiotic metabolism and disposition in human lung cell models: Comparison with in vivo expression profiles

Drug Metabolism and Disposition

Volumn 40, Issue 10, 2012, Pages 1953-1965

  Courcot, Elisabeth ^a   Leclerc, Julie ^a   Lafitte, Jean Jacques ^b   Mensier, Eric ^c   Jaillard, Sophie ^c   Gosset, Philippe ^e   Shirali, Pirouz ^d   Pottier, Nicolas ^a   Broly, Franck ^a   Lo Guidice, Jean Marc ^a  

^a Institut Fédératif de Recherche 114   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c Polyclinique du Bois   (France)

^d UNIVERSITÉ DU LITTORAL CÔTE D OPALE   (France)

^e INSERM U1019   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; MESSENGER RNA; TRANSCRIPTION FACTOR;

ARTICLE; BRONCHUS MUCOSA; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC ASSOCIATION; GENETIC CODE; GENETIC DIFFERENCE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS CELL; PRIMARY CELL CULTURE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; XENOBIOTIC METABOLISM;

BIOTRANSFORMATION; BRONCHI; CELL LINE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LUNG; LUNG NEOPLASMS; MEMBRANE TRANSPORT PROTEINS; PRIMARY CELL CULTURE; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATORY MUCOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; XENOBIOTICS;

EID: 84866443114     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.046896     Document Type: Article

References (41)

1. Aninat C, Piton A, Glaise D, Le Charpentier T, Langouët S, Morel F, Guguen-Guillouzo C, and Guillouzo A (2006) Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 34:75-83. (Pubitemid 43042648)
2. Baer BR, Rettie AE, and Henne KR (2005) Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate. Chem Res Toxicol 18:855-864. (Pubitemid 40705452)
3. Baker SD, Verweij J, Cusatis GA, van Schaik RH, Marsh S, Orwick SJ, Franke RM, Hu S, Schuetz EG, Lamba V, et al. (2009) Pharmacogenetic pathway analysis of docetaxel elimination. Clin Pharmacol Ther 85:155-163.
4. Berger W, Setinek U, Hollaus P, Zidek T, Steiner E, Elbling L, Cantonati H, Attems J, Gsur A, and Micksche M (2005) Multidrug resistance markers P-glycoprotein, multidrug resistance protein 1, and lung resistance protein in non-small cell lung cancer: prognostic implications. J Cancer Res Clin Oncol 131:355-363. (Pubitemid 40674620)
5. Bourgine J, Billaut-Laden I, Happillon M, Lo-Guidice JM, Maunoury V, Imbenotte M, and Broly F (2012) Gene expression profiling of systems involved in the metabolism and the disposition of xenobiotics: comparison between human intestinal biopsy samples and colon cell lines. Drug Metab Dispos 40:694-705.
6. Campa D, Müller P, Edler L, Knoefel L, Barale R, Heussel CP, Thomas M, Canzian F, and Risch A (2012) A comprehensive study of polymorphisms in ABCB1, ABCC2 and ABCG2 and lung cancer chemotherapy response and prognosis. Int J Cancer doi: 10.1002/ijc27567.
7. Castell JV, Donato MT, and Gómez-Lechón MaJ (2005) Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach. Exp Toxicol Pathol 57 (Suppl)1:189-204.
8. Chang A (2011) Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC. Lung Cancer 71:3-10.
9. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, and Deeley RG (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654. (Pubitemid 23012438)
10. Endter S, Francombe D, Ehrhardt C, and Gumbleton M (2009) RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models. J Pharm Pharmacol 61:583-591.
11. Flaim CJ, Chien S, and Bhatia SN (2005) An extracellular matrix microarray for probing cellular differentiation. Nat Methods 2:119-125. (Pubitemid 41131033)
12. Foster KA, Oster CG, Mayer MM, Avery ML, and Audus KL (1998) Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism. Exp Cell Res 243:359-366. (Pubitemid 28488846)
13. Gifford AJ, Haber M, Witt TL, Whetstine JR, Taub JW, Matherly LH, and Norris MD (2002) The E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells. Leukemia 16:2379-2387. (Pubitemid 36054371)
14. Goldman ID and Matherly LH (1985) The cellular pharmacology of methotrexate. Pharmacol Ther 28:77-102. (Pubitemid 15015465)
15. Gómez-Lechón MJ, Donato MT, Castell JV, and Jover R (2004) Human hepatocytes in primary culture: the choice to investigate drug metabolism in man. Current Drug Metabolism 5:443-462. (Pubitemid 39276606)
16. Gottesman MM (2002) Mechanisms of cancer drug resistance. Annu Rev Med 53:615-627.
17. Guillouzo A, Corlu A, Aninat C, Glaise D, Morel F, and Guguen-Guillouzo C (2007) The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 168:66-73. (Pubitemid 46659919)
18. Hart SN, Li Y, Nakamoto K, Subileau EA, Steen D, and Zhong XB (2010) A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues. Drug Metab Dispos 38:988-994.
19. Hodgson E and Rose RL (2007) The importance of cytochrome P450 2B6 in the human metabolism of environmental chemicals. Pharmacol Ther 113:420-428. (Pubitemid 46149054)
20. Hukkanen J, Lassila A, Päivärinta K, Valanne S, Sarpo S, Hakkola J, Pelkonen O, and Raunio H (2000) Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 22:360-366. (Pubitemid 30343363)
21. Kim M, Lee JY, Jones CN, Revzin A, and Tae G (2010) Heparin-based hydrogel as a matrix for encapsulation and cultivation of primary hepatocytes. Biomaterials 31:3596-3603.
22. Kunz-Schughart LA, Doetsch J, Mueller-Klieser W, and Groebe K (2000) Proliferative activity and tumorigenic conversion: impact on cellular metabolism in 3-D culture. Am J Physiol Cell Physiol 278:C765-C80.
23. Kunzschughart L, Simm A, and Muellerklieser W (1995) Oncogene-associated transformation of rodent fibroblasts is accompanied by large morphologic and metabolic alterations. Oncol Rep 2:651-661.
24. Lang R, Stern MM, Smith L, Liu Y, Bharadwaj S, Liu G, Baptista PM, Bergman CR, Soker S, Yoo JJ, et al. (2011) Three-dimensional culture of hepatocytes on porcine liver tissue-derived extracellular matrix. Biomaterials 32:7042-7521.
25. Lanza DL and Yost GS (2001) Selective dehydrogenation/oxygenation of 3-methylindole by cytochrome P450 enzymes. Drug Metab Dispos 29:950-953. (Pubitemid 32605908)
26. Leclerc J, Tournel G, Courcot-Ngoubo Ngangue E, Pottier N, Lafitte JJ, Jaillard S, Mensier E, Lhermitte M, Broly F, and Lo-Guidice JM (2010) Profiling gene expression of whole cytochrome P450 superfamily in human bronchial and peripheral lung tissues: differential expression in non-small cell lung cancers. Biochimie 92:292-306.
27. Leclerc J, Courcot-Ngoubo Ngangue E, Cauffiez C, Allorge D, Pottier N, Lafitte JJ, Debaert M, Jaillard S, Broly F, and Lo-Guidice JM (2011) Xenobiotic metabolism and disposition in human lung: transcript profiling in non-tumoral and tumoral tissues. Biochimie 93:1012-1027.
28. LeCluyse EL (2001) Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. Eur J Pharm Sci 13:343-368.
29. Liu S, Huang H, Lu X, Golinski M, Comesse S, Watt D, Grossman RB, and Moscow JA (2003) Down-regulation of thiamine transporter THTR2 gene expression in breast cancer and its association with resistance to apoptosis. Mol Cancer Res 1:665-673. (Pubitemid 36870519)
30. Mees ST, Mardin WA, Schleicher C, Colombo-Benkmann M, Senninger N, and Haier J (2011) Role of tumor microenvironment on gene expression in pancreatic cancer tumor models. J Surg Res 171:136-142.
31. Munoz M, Henderson M, Haber M, and Norris M (2007) Role of the MRP1/ABCC1 multidrug transporter protein in cancer. IUBMB Life 59:752-757. (Pubitemid 351412076)
32. Nakata K, Tanaka Y, Nakano T, Adachi T, Tanaka H, Kaminuma T, and Ishikawa T (2006) Nuclear receptor-mediated transcriptional regulation in phase I, II, and III xenobiotic metabolizing systems. Drug Metab Pharmacokinet 21:437-457.
33. Nebert DW and Dalton TP (2006) The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat Rev Cancer 6:947-960. (Pubitemid 44862679)
34. Obaidat A, Roth M, and Hagenbuch B (2012) The expression and function of organic anion transporting polypeptides in normal tissues and in cancer. Annu Rev Pharmacol Toxicol 52:135-151.
35. Olsavsky KM, Page JL, Johnson MC, Zarbl H, Strom SC, and Omiecinski CJ (2007) Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues. Toxicol Appl Pharmacol 222:42-56. (Pubitemid 46964871)
36. Ota E, Abe Y, Oshika Y, Ozeki Y, Iwasaki M, Inoue H, Yamazaki H, Ueyama Y, Takagi K, and Ogata T (1995) Expression of the multidrug resistance- associated protein (MRP) gene in non-small-cell lung cancer. Br J Cancer 72:550-554.
37. Rauchwerger DR, Firby PS, Hedley DW, and Moore MJ (2000) Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivity. Cancer Res 60:6075-6079.
38. Saviozzi S, Cordero F, Lo Iacono M, Novello S, Scagliotti GV, and Calogero RA (2006) Selection of suitable reference genes for accurate normalization of gene expression profile studies in non-small cell lung cancer. BMC Cancer 6:200.
39. Shimada T and Fujii-Kuriyama Y (2004) Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1. Cancer Sci 95:1-6. (Pubitemid 38208399)
40. Thum T, Erpenbeck VJ, Moeller J, Hohlfeld JM, Krug N, and Borlak J (2006) Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers. Environ Health Perspect 114:1655-1661. (Pubitemid 44718269)
41. Willey JC, Coy EL, Frampton MW, Torres A, Apostolakos MJ, Hoehn G, Schuermann WH, Thilly WG, Olson DE, Hammersley JR, et al. (1997) Quantitative RT-PCR measurement of cytochromes p450 1A1, 1B1, and 2B7, microsomal epoxide hydrolase, and NADPH oxidoreductase expression in lung cells of smokers and nonsmokers. Am J Respir Cell Mol Biol 17:114-124. (Pubitemid 127500828)